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PROS PROS tsaD tsaD cas2-2 cas2-2 mnmA mnmA FLIA FLIA WS1648 WS1648 valS valS RPOA RPOA rnhB rnhB rimO rimO tilS tilS miaB miaB NUSA NUSA ASPS ASPS WS1792 WS1792 WS2115 WS2115 WS1819 WS1819 WS1875 WS1875 WS1884 WS1884 RPOD RPOD RNC RNC RNHA RNHA dnaG dnaG PRIA PRIA WS1966 WS1966 miaA miaA WS1979 WS1979 WS2003 WS2003 rbfA rbfA TRMA TRMA RPON-2 RPON-2 WS2098 WS2098 gltX1 gltX1 WS2155 WS2155 queH queH rlmN rlmN KSGA KSGA rnj rnj rny rny lysS lysS GLYQ GLYQ WS0143 WS0143 trmB trmB rlmH rlmH WS0162 WS0162 rsmH rsmH ILES ILES ARGS ARGS GLYS GLYS METS METS rpoZ rpoZ TYRS TYRS GLTX GLTX NUSB NUSB trpS trpS ALAS ALAS DNAB DNAB WS0417 WS0417 CYSS CYSS rsmI rsmI WS0446 WS0446 NUSG NUSG RPOB RPOB FMT FMT rimM rimM trmD trmD ybeY ybeY HLYA HLYA cmoA cmoA WS0589 WS0589 cmoB cmoB truA truA RHO RHO gidA gidA THRS THRS selA selA gidB gidB SERS SERS truB truB csrA csrA PNP PNP truD truD leuS leuS thdF thdF PHES PHES pheT pheT RPON RPON WS1423 WS1423 cas2 cas2 hisS-3 hisS-3 WS1458 WS1458 trmL trmL WS1515 WS1515 TGT TGT
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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PROSPROLYL-TRNA SYNTHETASE; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (570 aa)
tsaDMETAL DEPENDENT PROTEASE with possible chaperone activity; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (331 aa)
cas2-2Hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (96 aa)
mnmATRNA METHYLTRANSFERASE; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (345 aa)
FLIARNA POLYMERASE SIGMA FACTOR; Belongs to the sigma-70 factor family. (235 aa)
WS1648Conserved hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (155 aa)
valSVALYL-TRNA SYNTHETASE; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (894 aa)
RPOARNA POLYMERASE ALPHA SUBUNIT; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (331 aa)
rnhBRIBONUCLEASE HII RNASE HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (183 aa)
rimOConserved hypothetical protein-2-methylthioadenine synthetase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (439 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (326 aa)
miaBConserved hypothetical protein-2-methylthioadenine synthetase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (433 aa)
NUSATRANSCRIPTION ELONGATION FACTOR; Participates in both transcription termination and antitermination. (375 aa)
ASPSASPARTYL-TRNA SYNTHETASE; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (587 aa)
WS1792ATP_bind_3 domain-containing protein; Conserved hypothetical protein-Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; Belongs to the TtcA family. (248 aa)
WS2115PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE. (244 aa)
WS1819RNA NUCLEOTIDYLTRANSFERASE; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (379 aa)
WS1875RIBONUCLEASE; Belongs to the RNR ribonuclease family. (653 aa)
WS1884Conserved hypothetical protein-Predicted endonuclease; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (127 aa)
RPODRNA POLYMERASE SIGMA FACTOR; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (620 aa)
RNCRIBONUCLEASE III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (238 aa)
RNHARIBONUCLEASE HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (139 aa)
dnaGDNA PRIMASE PROTEIN; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (554 aa)
PRIAPRIMOSOMAL PROTEIN N'-SUPEFAMILY II HELICASE-REPLICATION FACTOR Y; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (614 aa)
WS1966Conserved hypothetical protein-N6-adenine-specific methylase. (194 aa)
miaATRNA DELTA-2-ISOPENTENYLPYROPHOSPHATE; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (300 aa)
WS1979PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE; Belongs to the pseudouridine synthase RsuA family. (293 aa)
WS2003PUTATIVE ATP /GTP BINDING PROTEIN; Belongs to the SelU family. (338 aa)
rbfAConserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (119 aa)
TRMATRNA (URACIL-5-)-METHYLTRANSFERASE; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (370 aa)
RPON-2RNA POLYMERASE SIGMA-54 FACTOR; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (420 aa)
WS2098Hypothetical protein. (139 aa)
gltX1GLUTAMYL-TRNA SYNTHETASE; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (465 aa)
WS2155Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (220 aa)
queHConserved hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (370 aa)
rlmNConserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (359 aa)
KSGAPUTATIVE DIMETHYLADENOSINE TRANSFERASE 16S RRNA DIMETHYLASEEC 2.1.1. (239 aa)
rnjConserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (681 aa)
rnyKH DOMAIN PROTEIN; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (472 aa)
lysSLYSYL-TRNA SYNTHETASE; Belongs to the class-II aminoacyl-tRNA synthetase family. (507 aa)
GLYQGLYCYL-TRNA SYNTHETASE ALPHA CHAIN. (293 aa)
WS0143PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (320 aa)
trmBConserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (388 aa)
rlmHConserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (154 aa)
WS0162PUTATIVE TRANSCRIPTIONAL REGULATOR; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (346 aa)
rsmHConserved hypothetical protein CJ0693C; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (303 aa)
ILESISOLEUCYL-TRNA SYNTHETASE; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (915 aa)
ARGSARGINYL-TRNA SYNTHETASE. (528 aa)
GLYSGLYCYL-TRNA SYNTHETASE BETA CHAIN. (682 aa)
METSMETHIONYL-TRNA SYNTHETASE; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (649 aa)
rpoZHypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (71 aa)
TYRSTYROSYL-TRNA SYNTHETASE; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (406 aa)
GLTXGLUTAMYL-TRNA SYNTHETASE; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (438 aa)
NUSBTRANSCRIPTION TERMINATION PROTEIN; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (135 aa)
trpSTRYPTOPHANYL-TRNA SYNTHETASE; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (328 aa)
ALASALANYL-TRNA SYNTHETASE; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (855 aa)
DNABREPLICATIVE DNA HELICASE EC 3.6.1; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (473 aa)
WS0417PUTATIVE RIBOSOMAL PSEUDOURIDINE SYNTHASE. (308 aa)
CYSSCYSTEINYL-TRNA SYNTHETASE FRAGMENT; Belongs to the class-I aminoacyl-tRNA synthetase family. (467 aa)
rsmIPUTATIVE METHYLASE; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (271 aa)
WS0446Conserved hypothetical protein; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (257 aa)
NUSGTRANSCRIPTION ANTITERMINATION PROTEIN NUSG; Participates in transcription elongation, termination and antitermination. (176 aa)
RPOBDNA-DIRECTED RNA POLYMERASE, BETA SUBUNIT RPOB; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2883 aa)
FMTMETHIONYL-TRNA FORMYLTRANSFERASE; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (305 aa)
rimMPROBABLE 16S RRNA PROCESSING PROTEIN RIMM. (130 aa)
trmDTRNA-METHYLTRANSFERASE; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (237 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (140 aa)
HLYAPUTATIVE HEMOLYSIN. (236 aa)
cmoAConserved hypothetical protein; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). (240 aa)
WS0589Hypothetical protein; Belongs to the sigma-70 factor family. ECF subfamily. (158 aa)
cmoBConserved hypothetical protein; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. (277 aa)
truATRNA PSEUDOURIDINE SYNTHASE; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (267 aa)
RHOTRANSCRIPTION TERMINATION FACTOR; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (453 aa)
gidAGLUCOSE INHIBITED DIVISION PROTEIN A HOMOLOG; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (625 aa)
THRSTHREONYL-TRNA SYNTHETASE; Belongs to the class-II aminoacyl-tRNA synthetase family. (536 aa)
selAL-SERYL-TRNA(SEC) SELENIUM TRANSFERASE; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (444 aa)
gidBGLUCOSE INHIBITED DIVISION PROTEIN B; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (193 aa)
SERSSERYL-TRNA SYNTHETASE; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa)
truBTRNA PSEUDOURIDINE SYNTHASE B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (291 aa)
csrAHypothetical protein; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (76 aa)
PNPNUCLEOTIDYLTRANSFERASE; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (736 aa)
truDHypothetical protein; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (361 aa)
leuSLEUCYL-TRNA SYNTHETASE; Belongs to the class-I aminoacyl-tRNA synthetase family. (819 aa)
thdFPUTATIVE TRNA MODIFICATION GTPASE TRME; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (432 aa)
PHESPHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN PHENYLALANINE--TRNA LIGASE ALPHA CHAIN PHERS; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (330 aa)
pheTPHENYLALANINE TRNA SYNTHETASE, BETA-SUBUNIT; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (786 aa)
RPONRNA POLYMERASE SIGMA-54 FACTOR; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (404 aa)
WS1423PUTATIVE RNA POLYMERASE SIGMA FACTOR; Belongs to the sigma-70 factor family. ECF subfamily. (157 aa)
cas2Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (104 aa)
hisS-3HISTIDYL-TRNA SYNTHETASE. (442 aa)
WS1458CONSERVED HYPOTHETICAL 29.9 KDA PROTEIN. (248 aa)
trmLPUTATIVE RNA METHYLASE; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (153 aa)
WS1515Conserved hypothetical protein-2-methylthioadenine synthetase. (416 aa)
TGTQUEUINE TRNA-RIBOSYLTRANSFERASE; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (377 aa)
Your Current Organism:
Wolinella succinogenes
NCBI taxonomy Id: 273121
Other names: W. succinogenes DSM 1740, Wolinella succinogenes DSM 1740
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