(18 nodes) RHO GTPases Activate WASPs and WAVEs, and Arp2/3 complex binding network (Penicillium expansum)

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Your Input:
	PEX2_087760	Actin-related protein 3; Belongs to the actin family. (437 aa)
	PEX2_051170	Lipase, class 3. (757 aa)
	PEX2_069060	Uncharacterized protein. (412 aa)
	PEX2_062150	WH2 domain-containing protein. (425 aa)
	PEX2_091340	Nucleotide-binding, alpha-beta plait. (785 aa)
	PEX2_091330	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
	PEX2_040250	SLA1 homology domain 1, SHD1. (1116 aa)
	PEX2_104850	DUF2013 domain-containing protein. (737 aa)
	PEX2_061270	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
	PEX2_070810	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (187 aa)
	PEX2_077250	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (193 aa)
	PEX2_066860	Myosin tail 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1266 aa)
	PEX2_091640	Uncharacterized protein. (1204 aa)
	PEX2_088230	Glia maturation factor beta. (141 aa)
	PEX2_085830	Fps/Fes/Fer/CIP4 homology. (704 aa)
	PEX2_001730	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (342 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (887 aa)
	PEX2_049080	Neutrophil cytosol factor 2 p67phox. (804 aa)

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX2_001730	PEX2_040250	A0A0A2KSJ3	A0A0A2J0A9	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	SLA1 homology domain 1, SHD1.	0.873
PEX2_001730	PEX2_049080	A0A0A2KSJ3	A0A0A2KXB9	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Neutrophil cytosol factor 2 p67phox.	0.594
PEX2_001730	PEX2_051170	A0A0A2KSJ3	A0A0A2I7Q7	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Lipase, class 3.	0.999
PEX2_001730	PEX2_061270	A0A0A2KSJ3	A0A0A2JDT1	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.998
PEX2_001730	PEX2_062150	A0A0A2KSJ3	A0A0A2IVM1	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	WH2 domain-containing protein.	0.732
PEX2_001730	PEX2_070810	A0A0A2KSJ3	A0A0A2JIM5	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.999
PEX2_001730	PEX2_077250	A0A0A2KSJ3	A0A0A2JNB2	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.999
PEX2_001730	PEX2_087760	A0A0A2KSJ3	A0A0A2I084	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 3; Belongs to the actin family.	0.999
PEX2_001730	PEX2_088230	A0A0A2KSJ3	A0A0A2K0P5	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Glia maturation factor beta.	0.817
PEX2_001730	PEX2_091330	A0A0A2KSJ3	A0A0A2IXW4	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.997
PEX2_001730	PEX2_091340	A0A0A2KSJ3	A0A0A2IW53	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Nucleotide-binding, alpha-beta plait.	0.990
PEX2_001730	PEX2_091640	A0A0A2KSJ3	A0A0A2JVD7	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Uncharacterized protein.	0.980
PEX2_001730	PEX2_104850	A0A0A2KSJ3	A0A0A2J393	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	DUF2013 domain-containing protein.	0.969
PEX2_001730	SLX4	A0A0A2KSJ3	A0A0A2KT94	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.975
PEX2_040250	PEX2_001730	A0A0A2J0A9	A0A0A2KSJ3	SLA1 homology domain 1, SHD1.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.873
PEX2_040250	PEX2_049080	A0A0A2J0A9	A0A0A2KXB9	SLA1 homology domain 1, SHD1.	Neutrophil cytosol factor 2 p67phox.	0.819
PEX2_040250	PEX2_051170	A0A0A2J0A9	A0A0A2I7Q7	SLA1 homology domain 1, SHD1.	Lipase, class 3.	0.876
PEX2_040250	PEX2_061270	A0A0A2J0A9	A0A0A2JDT1	SLA1 homology domain 1, SHD1.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.881
PEX2_040250	PEX2_062150	A0A0A2J0A9	A0A0A2IVM1	SLA1 homology domain 1, SHD1.	WH2 domain-containing protein.	0.821
PEX2_040250	PEX2_066860	A0A0A2J0A9	A0A0A2JTQ3	SLA1 homology domain 1, SHD1.	Myosin tail 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.541