(17 nodes) HDR through Single Strand Annealing (SSA), and Sensing of DNA Double Strand Breaks network (Penicillium expansum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PEX2_044180	Rad9-like Rad53-binding domain, fungi. (1429 aa)
	PEX2_108620	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (1107 aa)
	PEX2_061050	EthD domain-containing protein. (155 aa)
	PEX2_103290	Uncharacterized protein. (1669 aa)
	PEX2_057880	Rad52/22 double-strand break repair protein. (607 aa)
	PEX2_076170	PIK-related kinase, FATC; Belongs to the PI3/PI4-kinase family. (2172 aa)
	PEX2_052350	Uncharacterized protein. (204 aa)
	PEX2_076180	Telomere-length maintenance and DNA damage repair. (400 aa)
	PEX2_052340	PIK-related kinase, FATC; Belongs to the PI3/PI4-kinase family. (1956 aa)
	PEX2_021140	Recombination/repair protein Rad50. (1383 aa)
	PEX2_015670	3'-5' exonuclease domain-containing protein. (1435 aa)
	PEX2_027860	Calcium/calmodulin-dependent/calcium-dependent protein kinase. (534 aa)
	PEX2_015170	Uncharacterized protein. (823 aa)
	PEX2_015370	Zinc finger, RING-type. (204 aa)
	PEX2_011170	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family. (1382 aa)
	PEX2_010850	Nucleic acid-binding, OB-fold. (278 aa)
	PEX2_101650	DNA recombination/repair protein RecA, monomer-monomer interface; Belongs to the RecA family. (637 aa)

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX2_010850	PEX2_011170	A0A0A2KST9	A0A0A2K8W4	Nucleic acid-binding, OB-fold.	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family.	0.774
PEX2_010850	PEX2_015170	A0A0A2KST9	A0A0A2K4K9	Nucleic acid-binding, OB-fold.	Uncharacterized protein.	0.744
PEX2_010850	PEX2_015370	A0A0A2KST9	A0A0A2K4M4	Nucleic acid-binding, OB-fold.	Zinc finger, RING-type.	0.746
PEX2_010850	PEX2_015670	A0A0A2KST9	A0A0A2K1V3	Nucleic acid-binding, OB-fold.	3'-5' exonuclease domain-containing protein.	0.999
PEX2_010850	PEX2_021140	A0A0A2KST9	A0A0A2K031	Nucleic acid-binding, OB-fold.	Recombination/repair protein Rad50.	0.664
PEX2_010850	PEX2_027860	A0A0A2KST9	A0A0A2K3J4	Nucleic acid-binding, OB-fold.	Calcium/calmodulin-dependent/calcium-dependent protein kinase.	0.828
PEX2_010850	PEX2_044180	A0A0A2KST9	A0A0A2IJR0	Nucleic acid-binding, OB-fold.	Rad9-like Rad53-binding domain, fungi.	0.558
PEX2_010850	PEX2_052340	A0A0A2KST9	A0A0A2JZ39	Nucleic acid-binding, OB-fold.	PIK-related kinase, FATC; Belongs to the PI3/PI4-kinase family.	0.946
PEX2_010850	PEX2_052350	A0A0A2KST9	A0A0A2JWV6	Nucleic acid-binding, OB-fold.	Uncharacterized protein.	0.946
PEX2_010850	PEX2_057880	A0A0A2KST9	A0A0A2JLI2	Nucleic acid-binding, OB-fold.	Rad52/22 double-strand break repair protein.	0.981
PEX2_010850	PEX2_061050	A0A0A2KST9	A0A0A2JDJ9	Nucleic acid-binding, OB-fold.	EthD domain-containing protein.	0.898
PEX2_010850	PEX2_076170	A0A0A2KST9	A0A0A2JMS7	Nucleic acid-binding, OB-fold.	PIK-related kinase, FATC; Belongs to the PI3/PI4-kinase family.	0.797
PEX2_010850	PEX2_076180	A0A0A2KST9	A0A0A2JWY3	Nucleic acid-binding, OB-fold.	Telomere-length maintenance and DNA damage repair.	0.797
PEX2_010850	PEX2_101650	A0A0A2KST9	A0A0A2KTZ6	Nucleic acid-binding, OB-fold.	DNA recombination/repair protein RecA, monomer-monomer interface; Belongs to the RecA family.	0.926
PEX2_010850	PEX2_103290	A0A0A2KST9	A0A0A2JJC2	Nucleic acid-binding, OB-fold.	Uncharacterized protein.	0.922
PEX2_010850	PEX2_108620	A0A0A2KST9	A0A0A2JC73	Nucleic acid-binding, OB-fold.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.999
PEX2_011170	PEX2_010850	A0A0A2K8W4	A0A0A2KST9	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family.	Nucleic acid-binding, OB-fold.	0.774
PEX2_011170	PEX2_015170	A0A0A2K8W4	A0A0A2K4K9	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family.	Uncharacterized protein.	0.774
PEX2_011170	PEX2_015370	A0A0A2K8W4	A0A0A2K4M4	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family.	Zinc finger, RING-type.	0.989
PEX2_011170	PEX2_015670	A0A0A2K8W4	A0A0A2K1V3	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family.	3'-5' exonuclease domain-containing protein.	0.998