(16 nodes) Clathrin binding, and EH domain network (Penicillium expansum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	PEX2_095880	Protein kinase domain-containing protein. (1016 aa)
	PEX2_034620	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1669 aa)
	PEX2_035180	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (945 aa)
	PEX2_097660	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (304 aa)
	PEX2_056220	Epsin-like, N-terminal. (621 aa)
	PEX2_095080	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (739 aa)
	PEX2_104330	Epsin-like, N-terminal. (569 aa)
	PEX2_061430	Uncharacterized protein. (658 aa)
	PEX2_004620	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (710 aa)
	PEX2_073340	Clathrin adaptor, mu subunit, C-terminal; Belongs to the adaptor complexes medium subunit family. (444 aa)
	PEX2_019690	Epsin-like, N-terminal. (1042 aa)
	PEX2_034040	Uncharacterized protein. (455 aa)
	PEX2_087050	EPS15 homology (EH). (496 aa)
	PEX2_012310	AP complex, mu/sigma subunit. (430 aa)
	PEX2_107680	Rad60-SLD_2 domain-containing protein. (312 aa)
	PEX2_018650	Calcium-binding EF-hand. (1297 aa)

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX2_004620	PEX2_012310	A0A0A2JNW4	A0A0A2KCX4	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	AP complex, mu/sigma subunit.	0.707
PEX2_004620	PEX2_018650	A0A0A2JNW4	A0A0A2KZV9	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Calcium-binding EF-hand.	0.995
PEX2_004620	PEX2_034620	A0A0A2JNW4	A0A0A2IR79	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.945
PEX2_004620	PEX2_035180	A0A0A2JNW4	A0A0A2IXB1	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.829
PEX2_004620	PEX2_061430	A0A0A2JNW4	A0A0A2JML8	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Uncharacterized protein.	0.840
PEX2_004620	PEX2_073340	A0A0A2JNW4	A0A0A2JXN8	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Clathrin adaptor, mu subunit, C-terminal; Belongs to the adaptor complexes medium subunit family.	0.726
PEX2_004620	PEX2_087050	A0A0A2JNW4	A0A0A2K0T7	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	EPS15 homology (EH).	0.787
PEX2_004620	PEX2_095080	A0A0A2JNW4	A0A0A2J6M1	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.715
PEX2_004620	PEX2_097660	A0A0A2JNW4	A0A0A2IXB4	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.723
PEX2_004620	PEX2_104330	A0A0A2JNW4	A0A0A2JBU9	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Epsin-like, N-terminal.	0.808
PEX2_004620	PEX2_107680	A0A0A2JNW4	A0A0A2KLF8	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Rad60-SLD_2 domain-containing protein.	0.715
PEX2_012310	PEX2_004620	A0A0A2KCX4	A0A0A2JNW4	AP complex, mu/sigma subunit.	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	0.707
PEX2_012310	PEX2_018650	A0A0A2KCX4	A0A0A2KZV9	AP complex, mu/sigma subunit.	Calcium-binding EF-hand.	0.922
PEX2_012310	PEX2_019690	A0A0A2KCX4	A0A0A2JZA1	AP complex, mu/sigma subunit.	Epsin-like, N-terminal.	0.710
PEX2_012310	PEX2_034040	A0A0A2KCX4	A0A0A2JZJ1	AP complex, mu/sigma subunit.	Uncharacterized protein.	0.403
PEX2_012310	PEX2_034620	A0A0A2KCX4	A0A0A2IR79	AP complex, mu/sigma subunit.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.909
PEX2_012310	PEX2_035180	A0A0A2KCX4	A0A0A2IXB1	AP complex, mu/sigma subunit.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.999
PEX2_012310	PEX2_056220	A0A0A2KCX4	A0A0A2J487	AP complex, mu/sigma subunit.	Epsin-like, N-terminal.	0.714
PEX2_012310	PEX2_061430	A0A0A2KCX4	A0A0A2JML8	AP complex, mu/sigma subunit.	Uncharacterized protein.	0.820
PEX2_012310	PEX2_073340	A0A0A2KCX4	A0A0A2JXN8	AP complex, mu/sigma subunit.	Clathrin adaptor, mu subunit, C-terminal; Belongs to the adaptor complexes medium subunit family.	0.999