(40 nodes) Actin cortical patch network (Penicillium expansum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PEX2_040250	SLA1 homology domain 1, SHD1. (1116 aa)
	PEX2_106090	Arf GTPase activating protein. (800 aa)
	PEX2_104850	DUF2013 domain-containing protein. (737 aa)
	PEX2_065070	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa)
	PEX2_065080	Uncharacterized protein. (631 aa)
	PEX2_061270	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
	PEX2_061920	Adenylyl cyclase-associated protein; Belongs to the CAP family. (530 aa)
	PEX2_061590	Calcium-binding EF-hand. (404 aa)
	PEX2_089330	Coronin; Belongs to the WD repeat coronin family. (601 aa)
	PEX2_070810	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (187 aa)
	PEX2_055540	Dynamin GTPase effector; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (694 aa)
	PEX2_082720	Ribosomal protein S18. (791 aa)
	PEX2_061430	Uncharacterized protein. (658 aa)
	PEX2_076810	Uncharacterized protein. (517 aa)
	PEX2_071280	Endonuclease/exonuclease/phosphatase. (1203 aa)
	PEX2_020000	Fps/Fes/Fer/CIP4 homology. (674 aa)
	PEX2_066860	Myosin tail 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1266 aa)
	PEX2_091640	Uncharacterized protein. (1204 aa)
	PEX2_075310	Uncharacterized protein. (371 aa)
	PEX2_019690	Epsin-like, N-terminal. (1042 aa)
	PEX2_088230	Glia maturation factor beta. (141 aa)
	PEX2_016270	Uncharacterized protein. (1657 aa)
	PEX2_085830	Fps/Fes/Fer/CIP4 homology. (704 aa)
	PEX2_044160	Ysc84 domain-containing protein. (388 aa)
	PEX2_094970	SH3 domain-containing protein. (1209 aa)
	PEX2_014730	SH3 domain-containing protein. (409 aa)
	PEX2_049080	Neutrophil cytosol factor 2 p67phox. (804 aa)
	PEX2_018650	Calcium-binding EF-hand. (1297 aa)
	PEX2_087760	Actin-related protein 3; Belongs to the actin family. (437 aa)
	PEX2_102480	Amphiphysin. (261 aa)
	PEX2_105550	Smooth muscle protein/calponin. (648 aa)
	PEX2_051170	Lipase, class 3. (757 aa)
	PEX2_016910	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (251 aa)
	PEX2_045330	Uncharacterized protein. (646 aa)
	PEX2_069060	Uncharacterized protein. (412 aa)
	PEX2_092780	VHS subgroup. (401 aa)
	PEX2_034620	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1669 aa)
	PEX2_062150	WH2 domain-containing protein. (425 aa)
	PEX2_091340	Nucleotide-binding, alpha-beta plait. (785 aa)
	PEX2_091330	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PEX2_014730	PEX2_040250	A0A0A2KVY4	A0A0A2J0A9	SH3 domain-containing protein.	SLA1 homology domain 1, SHD1.	0.826
PEX2_014730	PEX2_049080	A0A0A2KVY4	A0A0A2KXB9	SH3 domain-containing protein.	Neutrophil cytosol factor 2 p67phox.	0.417
PEX2_014730	PEX2_091640	A0A0A2KVY4	A0A0A2JVD7	SH3 domain-containing protein.	Uncharacterized protein.	0.848
PEX2_014730	PEX2_092780	A0A0A2KVY4	A0A0A2IL71	SH3 domain-containing protein.	VHS subgroup.	0.486
PEX2_014730	PEX2_106090	A0A0A2KVY4	A0A0A2J2K8	SH3 domain-containing protein.	Arf GTPase activating protein.	0.468
PEX2_016270	PEX2_016910	A0A0A2K1Z4	A0A0A2I7U9	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.646
PEX2_016270	PEX2_055540	A0A0A2K1Z4	A0A0A2JJ99	Uncharacterized protein.	Dynamin GTPase effector; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.622
PEX2_016270	PEX2_061270	A0A0A2K1Z4	A0A0A2JDT1	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.764
PEX2_016270	PEX2_065070	A0A0A2K1Z4	A0A0A2J8N0	Uncharacterized protein.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.443
PEX2_016270	PEX2_065080	A0A0A2K1Z4	A0A0A2JAY8	Uncharacterized protein.	Uncharacterized protein.	0.443
PEX2_016270	PEX2_070810	A0A0A2K1Z4	A0A0A2JIM5	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.529
PEX2_016270	PEX2_075310	A0A0A2K1Z4	A0A0A2JXI7	Uncharacterized protein.	Uncharacterized protein.	0.443
PEX2_016270	PEX2_087760	A0A0A2K1Z4	A0A0A2I084	Uncharacterized protein.	Actin-related protein 3; Belongs to the actin family.	0.734
PEX2_016270	PEX2_091640	A0A0A2K1Z4	A0A0A2JVD7	Uncharacterized protein.	Uncharacterized protein.	0.747
PEX2_016910	PEX2_016270	A0A0A2I7U9	A0A0A2K1Z4	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Uncharacterized protein.	0.646
PEX2_016910	PEX2_040250	A0A0A2I7U9	A0A0A2J0A9	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	SLA1 homology domain 1, SHD1.	0.879
PEX2_016910	PEX2_045330	A0A0A2I7U9	A0A0A2I9P1	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Uncharacterized protein.	0.924
PEX2_016910	PEX2_049080	A0A0A2I7U9	A0A0A2KXB9	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Neutrophil cytosol factor 2 p67phox.	0.814
PEX2_016910	PEX2_051170	A0A0A2I7U9	A0A0A2I7Q7	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Lipase, class 3.	0.549
PEX2_016910	PEX2_061270	A0A0A2I7U9	A0A0A2JDT1	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.875