67 items (Penicillium expansum) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PEX2_009590	DNA ligase. (824 aa)
	PEX2_089370	Cyclin, N-terminal; Belongs to the cyclin family. (436 aa)
	PEX2_096330	Uncharacterized protein. (507 aa)
	PEX2_032290	Reverse transcriptase, RNA-dependent DNA polymerase. (579 aa)
	PEX2_009450	Ribosomal protein S27a. (193 aa)
	PEX2_108930	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (315 aa)
	PEX2_108070	DNA helicase; Belongs to the MCM family. (954 aa)
	PEX2_108520	DNA polymerase alpha/epsilon, subunit B. (764 aa)
	PEX2_108620	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (1107 aa)
	PEX2_081370	Uncharacterized protein. (123 aa)
	PEX2_059080	BZIP domain-containing protein. (250 aa)
	PEX2_048150	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (505 aa)
	PEX2_070820	ATPase, AAA-type, core. (393 aa)
	PEX2_006810	DNA helicase; Belongs to the MCM family. (974 aa)
	PEX2_029700	DNA polymerase delta, subunit 4. (183 aa)
	PEX2_070530	DNA helicase; Belongs to the MCM family. (719 aa)
	PEX2_103290	Uncharacterized protein. (1669 aa)
	PEX2_081360	Reverse transcriptase Ty1/copia-type domain-containing protein. (525 aa)
	PEX2_029790	Origin recognition complex, subunit 6. (452 aa)
	PEX2_096950	Uncharacterized protein. (380 aa)
	PEX2_001630	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (271 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	PEX2_020270	Sec20. (762 aa)
	PEX2_030030	ATPase, AAA-type, core. (1162 aa)
	PEX2_021560	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. (2320 aa)
	PEX2_014550	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (326 aa)
	PEX2_065460	Integrase catalytic domain-containing protein. (1069 aa)
	PEX2_069300	DNA helicase; Belongs to the MCM family. (896 aa)
	PEX2_066190	Uncharacterized protein. (904 aa)
	PEX2_102670	Zinc finger, RING/FYVE/PHD-type. (100 aa)
	PEX2_019200	DNA polymerase. (1461 aa)
	PEX2_072600	Uncharacterized protein. (215 aa)
	PEX2_014740	Activator of mitotic machinery Cdc14 phosphatase activation C-terminal. (846 aa)
	PEX2_053780	Uncharacterized protein. (62 aa)
	PEX2_034430	DNA polymerase delta/II small subunit family. (544 aa)
	PEX2_103970	GINS complex. (181 aa)
	PEX2_075810	Nucleic acid-binding, OB-fold. (118 aa)
	PEX2_021970	Uncharacterized protein. (101 aa)
	PEX2_084800	Cyclin, N-terminal; Belongs to the cyclin family. (549 aa)
	PEX2_103980	Uncharacterized protein. (901 aa)
	PEX2_100660	Histone-fold. (272 aa)
	PEX2_073920	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. (352 aa)
	PEX2_078210	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2228 aa)
	PEX2_097070	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (657 aa)
	PEX2_041630	DNA polymerase. (1104 aa)
	PEX2_103170	GINS complex. (229 aa)
	PEX2_041660	DNA polymerase subunit Cdc27. (440 aa)
	PEX2_047250	DNA ligase. (876 aa)
	PEX2_110640	DNA helicase; Belongs to the MCM family. (1001 aa)
	PEX2_109860	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
	PEX2_099980	Uncharacterized protein. (146 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
	PEX2_084350	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (270 aa)
	PEX2_109870	Proliferating cell nuclear antigen, PCNA. (611 aa)
	PEX2_093050	Uncharacterized protein. (147 aa)
	PEX2_053770	Uncharacterized protein. (88 aa)
	PEX2_021530	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal. (352 aa)
	PEX2_081230	Sirtuin family. (715 aa)
	PEX2_103350	Cyclin, N-terminal; Belongs to the cyclin family. (459 aa)
	PEX2_015500	Cell division control protein; Belongs to the CDC6/cdc18 family. (639 aa)
	PEX2_076080	Uncharacterized protein. (401 aa)
	PEX2_107500	Histone-fold. (187 aa)
	PEX2_047530	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (501 aa)
	PEX2_010220	Ubiquitin-conjugating enzyme, E2. (446 aa)
	PEX2_100990	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (787 aa)
	PEX2_105640	Tetratricopeptide-like helical. (485 aa)
	PEX2_100960	Uncharacterized protein. (281 aa)

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	MCM7	A0A0A2JRP2	A0A0A2IM98	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.809
FEN1	PEX2_001630	A0A0A2JRP2	A0A0A2JP91	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.657
FEN1	PEX2_006810	A0A0A2JRP2	A0A0A2JH12	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.911
FEN1	PEX2_009590	A0A0A2JRP2	A0A0A2J7J3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.975
FEN1	PEX2_014550	A0A0A2JRP2	A0A0A2JV77	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.487
FEN1	PEX2_015500	A0A0A2JRP2	A0A0A2J5G5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.745
FEN1	PEX2_019200	A0A0A2JRP2	A0A0A2K3I5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.923
FEN1	PEX2_020270	A0A0A2JRP2	A0A0A2JSF5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Sec20.	0.951
FEN1	PEX2_021530	A0A0A2JRP2	A0A0A2J0Y2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal.	0.956
FEN1	PEX2_021560	A0A0A2JRP2	A0A0A2JSW4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal.	0.937
FEN1	PEX2_030030	A0A0A2JRP2	A0A0A2JSM1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATPase, AAA-type, core.	0.943
FEN1	PEX2_034430	A0A0A2JRP2	A0A0A2KE78	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase delta/II small subunit family.	0.972
FEN1	PEX2_041630	A0A0A2JRP2	A0A0A2L0B7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.992
FEN1	PEX2_041660	A0A0A2JRP2	A0A0A2L7K4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase subunit Cdc27.	0.837
FEN1	PEX2_047250	A0A0A2JRP2	A0A0A2IHI7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.977
FEN1	PEX2_047530	A0A0A2JRP2	A0A0A2I9G9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.859
FEN1	PEX2_048150	A0A0A2JRP2	A0A0A2JDP9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.938
FEN1	PEX2_069300	A0A0A2JRP2	A0A0A2K1U7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.931
FEN1	PEX2_070530	A0A0A2JRP2	A0A0A2JIK2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.930
FEN1	PEX2_070820	A0A0A2JRP2	A0A0A2JGR0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATPase, AAA-type, core.	0.902