(30 nodes) Thiamine metabolism network (Penicillium expansum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PEX2_106630	Alkaline phosphatase. (599 aa)
	PEX2_047220	Thiamin phosphate synthase superfamily. (783 aa)
	PEX2_007800	Alkaline phosphatase-like, alpha/beta/alpha; Belongs to the alkaline phosphatase family. (666 aa)
	PEX2_079140	Uncharacterized protein. (508 aa)
	PEX2_084000	Purple acid phosphatase. (497 aa)
	PEX2_079650	Aminotransferase, class V/Cysteine desulfurase. (392 aa)
	PEX2_079170	Phosphoesterase. (413 aa)
	PEX2_106860	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (765 aa)
	PEX2_100940	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (465 aa)
	PEX2_070480	NMT1 domain-containing protein. (342 aa)
	PEX2_002350	Uncharacterized protein. (181 aa)
	PEX2_069070	Cysteine desulfurase. (507 aa)
	ADK1	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (257 aa)
	PEX2_072540	Molybdenum cofactor biosynthesis, MoeB. (985 aa)
	PEX2_094260	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (538 aa)
	PEX2_088160	Nudix hydrolase domain-containing protein. (322 aa)
	PEX2_080930	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (341 aa)
	PEX2_081770	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (361 aa)
	PEX2_085210	Protein-tyrosine phosphatase, low molecular weight, mammalian. (204 aa)
	ADK2	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (255 aa)
	PEX2_082590	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (330 aa)
	PEX2_015390	Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB. (636 aa)
	PEX2_081580	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (526 aa)
	PEX2_077370	Heme oxygenase-like, multi-helical. (363 aa)
	PEX2_019190	Heme oxygenase-like, multi-helical. (510 aa)
	PEX2_040570	Nudix hydrolase domain-containing protein. (1236 aa)
	PEX2_099920	Phosphoesterase. (459 aa)
	PEX2_007220	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (527 aa)
	PEX2_042730	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (522 aa)
	PEX2_104220	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family. (445 aa)

Your Current Organism:

Penicillium expansum

NCBI taxonomy Id: 27334
Other names: ATCC 7861, CBS 325.48, P. expansum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK1	ADK2	A0A0A2JUD1	A0A0A2K773	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.901
ADK1	PEX2_040570	A0A0A2JUD1	A0A0A2ITL5	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Nudix hydrolase domain-containing protein.	0.628
ADK1	PEX2_080930	A0A0A2JUD1	A0A0A2K0P4	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.894
ADK1	PEX2_084000	A0A0A2JUD1	A0A0A2IQY6	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Purple acid phosphatase.	0.519
ADK1	PEX2_088160	A0A0A2JUD1	A0A0A2JYY8	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	Nudix hydrolase domain-containing protein.	0.628
ADK2	ADK1	A0A0A2K773	A0A0A2JUD1	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	0.901
ADK2	PEX2_040570	A0A0A2K773	A0A0A2ITL5	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Nudix hydrolase domain-containing protein.	0.628
ADK2	PEX2_080930	A0A0A2K773	A0A0A2K0P4	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.	0.894
ADK2	PEX2_084000	A0A0A2K773	A0A0A2IQY6	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Purple acid phosphatase.	0.519
ADK2	PEX2_088160	A0A0A2K773	A0A0A2JYY8	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	Nudix hydrolase domain-containing protein.	0.628
PEX2_002350	PEX2_047220	A0A0A2JR12	A0A0A2J5T1	Uncharacterized protein.	Thiamin phosphate synthase superfamily.	0.629
PEX2_002350	PEX2_079140	A0A0A2JR12	A0A0A2JJ23	Uncharacterized protein.	Uncharacterized protein.	0.569
PEX2_002350	PEX2_079170	A0A0A2JR12	A0A0A2IIM8	Uncharacterized protein.	Phosphoesterase.	0.569
PEX2_002350	PEX2_084000	A0A0A2JR12	A0A0A2IQY6	Uncharacterized protein.	Purple acid phosphatase.	0.669
PEX2_002350	PEX2_085210	A0A0A2JR12	A0A0A2K2Z5	Uncharacterized protein.	Protein-tyrosine phosphatase, low molecular weight, mammalian.	0.674
PEX2_002350	PEX2_099920	A0A0A2JR12	A0A0A2IWB6	Uncharacterized protein.	Phosphoesterase.	0.569
PEX2_007220	PEX2_007800	A0A0A2IYE7	A0A0A2JAM2	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family.	Alkaline phosphatase-like, alpha/beta/alpha; Belongs to the alkaline phosphatase family.	0.534
PEX2_007220	PEX2_015390	A0A0A2IYE7	A0A0A2KBX6	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family.	Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB.	0.534
PEX2_007220	PEX2_019190	A0A0A2IYE7	A0A0A2KVF7	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family.	Heme oxygenase-like, multi-helical.	0.670
PEX2_007220	PEX2_040570	A0A0A2IYE7	A0A0A2ITL5	Histidine phosphatase superfamily, clade-2; Belongs to the histidine acid phosphatase family.	Nudix hydrolase domain-containing protein.	0.540