STRINGSTRING
lipB lipB CDG11022.1 CDG11022.1 CDG11014.1 CDG11014.1 ggt ggt CDG10868.1 CDG10868.1 CDG10865.1 CDG10865.1 CDG10856.1 CDG10856.1 pagP pagP CDG10839.1 CDG10839.1 CDG10716.1 CDG10716.1 leuA leuA rffC rffC CDG13246.1 CDG13246.1 CDG13154.1 CDG13154.1 CDG13078.1 CDG13078.1 CDG13074.1 CDG13074.1 citC citC CDG12978.1 CDG12978.1 paaJ paaJ htrB htrB CDG12901.1 CDG12901.1 CDG12713.1 CDG12713.1 astA astA rimJ rimJ msbB msbB CDG12605.1 CDG12605.1 ompW ompW CDG12474.1 CDG12474.1 CDG12390.1 CDG12390.1 CDG12348.1 CDG12348.1 CDG12324.1 CDG12324.1 fabZ_2 fabZ_2 CDG12146.1 CDG12146.1 CDG12133.1 CDG12133.1 CDG11893.1 CDG11893.1 CDG11891.1 CDG11891.1 CDG11877.1 CDG11877.1 CDG11876.1 CDG11876.1 npdA npdA CDG11851.1 CDG11851.1 CDG11808.1 CDG11808.1 fabV fabV CDG11770.1 CDG11770.1 fabF fabF fabG fabG fabD fabD fabH fabH cat cat fabB fabB fadI fadI CDG13373.1 CDG13373.1 ypeA ypeA maeB maeB CDG13459.1 CDG13459.1 CDG13460.1 CDG13460.1 tmcA tmcA speG speG CDG13507.1 CDG13507.1 CDG13543.1 CDG13543.1 CDG13654.1 CDG13654.1 CDG13656.1 CDG13656.1 CDG13660.1 CDG13660.1 CDG13702.1 CDG13702.1 lpxA lpxA fabZ fabZ lpxD lpxD dapD dapD argA argA aas aas CDG13873.1 CDG13873.1 aceF aceF CDG14025.1 CDG14025.1 plsC plsC plsY plsY gcp gcp CDG14101.1 CDG14101.1 CDG14200.1 CDG14200.1 CDG14203.1 CDG14203.1 CDG14208.1 CDG14208.1 CDG14209.1 CDG14209.1 CDG14214.1 CDG14214.1 CDG14215.1 CDG14215.1 lpxP lpxP maA maA CDG14273.1 CDG14273.1 plsB plsB aceB aceB metA metA CDG14330.1 CDG14330.1 CDG14458.1 CDG14458.1 cysE cysE CDG14645.1 CDG14645.1 CDG14659.1 CDG14659.1 glmU glmU CDG14735.1 CDG14735.1 wecH wecH imm imm pta pta CDG14865.1 CDG14865.1 CDG14866.1 CDG14866.1 panZ panZ fadA fadA ttr ttr CDG14937.1 CDG14937.1 tsaE tsaE CDG15136.1 CDG15136.1 CDG15143.1 CDG15143.1 CDG15154.1 CDG15154.1 CDG15174.1 CDG15174.1 CDG15222.1 CDG15222.1 rimI rimI plsX plsX lpxL lpxL leuA-2 leuA-2 CDG11707.1 CDG11707.1 mdoC mdoC CDG11654.1 CDG11654.1 hemA_2 hemA_2 CDG11650.1 CDG11650.1 fabA fabA CDG11608.1 CDG11608.1 pflB pflB aat aat CDG11476.1 CDG11476.1 CDG11383.1 CDG11383.1 CDG11345.1 CDG11345.1 CDG11331.1 CDG11331.1 prpC prpC CDG11307.1 CDG11307.1 CDG11305.1 CDG11305.1 CDG11270.1 CDG11270.1 CDG11247.1 CDG11247.1 CDG11196.1 CDG11196.1 CDG11191.1 CDG11191.1 CDG11181.1 CDG11181.1 CDG11169.1 CDG11169.1 bioF bioF sucB sucB gltA gltA lnt lnt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lipBLipoyl-protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (222 aa)
CDG11022.1Putative acetyltransferase. (142 aa)
CDG11014.1Putative acetyltransferase. (175 aa)
ggtGamma-glutamyltranspeptidase precursor. (587 aa)
CDG10868.1Putative acetyltransferase. (172 aa)
CDG10865.1Putative acetyltransferase. (153 aa)
CDG10856.1Putative acetyltransferase. (182 aa)
pagPPutative lipid A palmitoyl transferase precursor; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (196 aa)
CDG10839.1Putative acetyltransferase. (152 aa)
CDG10716.1Putative acetyltransferase. (169 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa)
rffCLipopolysaccharide biosynthesis protein; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (242 aa)
CDG13246.1Putative exported protein. (179 aa)
CDG13154.1Putative phage-encoded acetyltransferase. (371 aa)
CDG13078.1Putative aminotransferase. (390 aa)
CDG13074.1Hypothetical protein. (374 aa)
citCCitrate lyase synthetase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (356 aa)
CDG12978.1Putative acetyltransferase. (172 aa)
paaJProbable beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
htrBLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
CDG12901.1Putative acetyltransferase. (234 aa)
CDG12713.1Putative 3-oxoacyl-(acyl-carrier-protein) synthase. (335 aa)
astAArginine succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. (343 aa)
rimJRibosomal-protein-alanine acetyltransferase. (194 aa)
msbBLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa)
CDG12605.1Putative glycoprotease. (233 aa)
ompWOuter membrane protein W. (210 aa)
CDG12474.1Putative formate acetyltransferase 3. (810 aa)
CDG12390.1Putative acyltransferase. (573 aa)
CDG12348.1Hypothetical protein. (146 aa)
CDG12324.1Putative gamma-glutamyltranspeptidase. (557 aa)
fabZ_2Putative thioesterase. (151 aa)
CDG12146.1Putative bacteriocin-activating protein. (149 aa)
CDG12133.1Putative acetyltransferase. (173 aa)
CDG11893.1Putative acetyltransferase. (139 aa)
CDG11891.1Hypothetical protein. (178 aa)
CDG11877.1Putative acetyltransferase. (234 aa)
CDG11876.1Putative acetyltransferase. (131 aa)
npdADeacetylase of acetyl-CoA synthetase,NAD-dependent; Belongs to the sirtuin family. Class III subfamily. (278 aa)
CDG11851.1Putative acetyltransferase. (201 aa)
CDG11808.1Putative aldolase. (280 aa)
fabVPutative short-chain alcohol dehydrogenase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (399 aa)
CDG11770.1Putative exported protein. (178 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
fabDmalonyl-CoA-[acyl-carrier-protein] transacylase. (309 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa)
catChloramphenicol acetyltransferase. (210 aa)
fabB3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
fadI3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa)
CDG13373.1Putative acetyltransferase. (179 aa)
ypeAPutative acetyltransferase; Belongs to the acetyltransferase family. YpeA subfamily. (141 aa)
maeBFused malic enzyme predictedoxidoreductase/predicted phosphotransacetylase. (759 aa)
CDG13459.1Putative acetyltransferase. (143 aa)
CDG13460.1Putative acetyltransferase. (141 aa)
tmcAPutative ATPase/acetyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (670 aa)
speGSpermidine N1-acetyltransferase. (183 aa)
CDG13507.1Putative acetyltransferase. (188 aa)
CDG13543.1Putative acetyltransferase. (161 aa)
CDG13654.1Putative acetyltransferase. (150 aa)
CDG13656.1Putative acetyltransferase. (166 aa)
CDG13660.1Putative acetyltransferase. (92 aa)
CDG13702.1Putative CoA-binding acetyltransferase. (882 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
fabZ(3R)-hydroxymyristoyl acyl carrier proteindehydratase. (151 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)-glucosamineN- acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (340 aa)
dapD2,3,4, 5-tetrahydropyridine-2-carboxylateN-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa)
argAN-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. (441 aa)
aasFused 2-acylglycerophospho-ethanolamineacyltransferase/acyl-acyl carrier protein synthetase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. (717 aa)
CDG13873.1Putative acetyltransferase. (176 aa)
aceFPyruvate dehydrogenase,dihydrolipoyltransacetylase component E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (643 aa)
CDG14025.1Putative acetyltransferase. (136 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (244 aa)
plsYPutative membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (214 aa)
gcpProbable O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (337 aa)
CDG14101.1Aminoglycoside acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, netilmicin, isepamicin and sisomicin. (146 aa)
CDG14200.1Putative beta-ketoacyl-ACP synthase. (409 aa)
CDG14203.1Putative beta-ketoacyl-ACP synthase. (389 aa)
CDG14208.1Putative glycosyl transferase. (563 aa)
CDG14209.1Putative acyl carrier protein dehydratase. (117 aa)
CDG14214.1Putative acyltransferase. (272 aa)
CDG14215.1Hypothetical protein. (241 aa)
lpxPPalmitoleoyl-acyl carrier protein-dependent acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa)
maAMaltose O-acetyltransferase. (185 aa)
CDG14273.1Putative transferase. (190 aa)
plsBGlycerol-3-phosphate O-acyltransferase; Belongs to the GPAT/DAPAT family. (821 aa)
aceBMalate synthase A; Belongs to the malate synthase family. (532 aa)
metAHomoserine O-transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
CDG14330.1Hypothetical protein. (124 aa)
CDG14458.1Putative acetyltransferase. (171 aa)
cysESerine acetyltransferase. (273 aa)
CDG14645.1Putative acetyltransferase. (315 aa)
CDG14659.1Putative acyltransferase. (298 aa)
glmUFused N-acetylglucosamine-1- phosphateuridyltransferase/glucosamine-1-phosphate acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (457 aa)
CDG14735.1Putative acetyltransferase. (150 aa)
wecHPutative membrane-associated acyltransferase; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (330 aa)
immBacteriocin immunity protein. (85 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (719 aa)
CDG14865.1Periplasmic protein. (187 aa)
CDG14866.1Putative acetyltransferase. (144 aa)
panZHypothetical protein; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family. (130 aa)
fadAFatty oxidation complex beta subunit; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa)
ttrAcetyltransferase. (182 aa)
CDG14937.1Putative acetyltransferase. (148 aa)
tsaEPutative ATPase. (156 aa)
CDG15136.1Putative acetyltransferase. (167 aa)
CDG15143.1Putative acetyltransferase. (200 aa)
CDG15154.1Putative acetyltransferase. (147 aa)
CDG15174.1Putative acetyltransferase. (167 aa)
CDG15222.1acetoacetate-CoA transferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
rimIRibosomal-protein-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (147 aa)
plsXFatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (344 aa)
lpxLLauryl-acyl carrier protein (ACP)-dependent acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
leuA-2Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (562 aa)
CDG11707.1Hypothetical protein. (181 aa)
mdoCGlucans biosynthesis protein; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (376 aa)
CDG11654.1Putative beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
hemA_2Putative aminotransferase. (403 aa)
CDG11650.1Putative acetyltransferase. (188 aa)
fabA3-hydroxydecanoyl-[acyl-carrier- protein]dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa)
CDG11608.1Putative 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (425 aa)
pflBPyruvate formate lyase I. (760 aa)
aatleucyl/phenylalanyl-tRNA-protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. (241 aa)
CDG11476.1Putative acetyltransferase. (139 aa)
CDG11383.1Putative acetyltransferase. (168 aa)
CDG11345.1Putative acetyltransferase. (176 aa)
CDG11331.1Putative acetyltransferase. (212 aa)
prpC2-methylcitrate synthase; Belongs to the citrate synthase family. (396 aa)
CDG11307.1Putative acetyltransferase. (283 aa)
CDG11305.1Putative acetyltransferase. (172 aa)
CDG11270.1Putative acetyltransferase. (170 aa)
CDG11247.1Putative acetyltransferase. (133 aa)
CDG11196.1Putative acetyltransferase. (180 aa)
CDG11191.1Putative acetyltransferase. (179 aa)
CDG11181.1Putative acetyltransferase. (151 aa)
CDG11169.1Putative short-chain dehydrogenase; Belongs to the arylamine N-acetyltransferase family. (264 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (383 aa)
sucBDihydrolipoyltranssuccinase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (430 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (509 aa)
Your Current Organism:
Serratia marcescens
NCBI taxonomy Id: 273526
Other names: S. marcescens subsp. marcescens Db11, Serratia marcescens subsp. marcescens Db11, Serratia marcescens subsp. marcescens str. Db11, Serratia marcescens subsp. marcescens strain Db11
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