STRINGSTRING
CDG14518.1 CDG14518.1 dhaM dhaM CDG14056.1 CDG14056.1 scrA scrA scrK scrK qseC qseC CDG13897.1 CDG13897.1 rssA rssA rbsK-2 rbsK-2 creC creC agaZ agaZ agaV agaV CDG13686.1 CDG13686.1 ppnK ppnK CDG13612.1 CDG13612.1 glrK glrK CDG13550.1 CDG13550.1 thiM thiM srlB srlB srlE srlE CDG13520.1 CDG13520.1 baeS baeS narQ narQ dhaK dhaK CDG13444.1 CDG13444.1 CDG13413.1 CDG13413.1 crr crr glk glk CDG13375.1 CDG13375.1 tctE tctE CDG13286.1 CDG13286.1 CDG13285.1 CDG13285.1 rcsC rcsC rcsD rcsD ttrS ttrS fruK fruK dhaK-2 dhaK-2 rfaE rfaE arcB arcB ptsN ptsN CDG14172.1 CDG14172.1 dgkA dgkA gntK gntK aceK aceK slyX slyX prkB prkB CDG14395.1 CDG14395.1 aroK aroK envZ envZ idnK idnK iolC iolC CDG14505.1 CDG14505.1 dhaL dhaL kdgK kdgK glpK glpK pfkA pfkA cpxA cpxA glnL glnL rdoA rdoA rbsK rbsK CDG14731.1 CDG14731.1 mtlA mtlA CDG14778.1 CDG14778.1 bglF bglF uhpB uhpB wzzE wzzE ubiB ubiB coaA coaA CDG14939.1 CDG14939.1 pmrB pmrB treB treB ascF ascF nadR nadR fruA fruA sgbK sgbK dgkA_2 dgkA_2 CDG12850.1 CDG12850.1 cheA cheA cheY cheY narX narX CDG12725.1 CDG12725.1 manX manX CDG12646.1 CDG12646.1 pykA pykA CDG12577.1 CDG12577.1 xylB xylB CDG12484.1 CDG12484.1 rstB rstB CDG12387.1 CDG12387.1 CDG12290.1 CDG12290.1 CDG12266.1 CDG12266.1 malX malX CDG12091.1 CDG12091.1 str str pdxY pdxY anmK anmK pykF pykF CDG12021.1 CDG12021.1 phoQ phoQ CDG11861.1 CDG11861.1 CDG11845.1 CDG11845.1 ispE ispE dcuS dcuS thiK thiK ptsG ptsG lpxK lpxK CDG11532.1 CDG11532.1 wzc wzc udk udk CDG11357.1 CDG11357.1 CDG11356.1 CDG11356.1 CDG11236.1 CDG11236.1 lsrK lsrK CDG11167.1 CDG11167.1 CDG11151.1 CDG11151.1 galK galK CDG11113.1 CDG11113.1 kdpD kdpD nagE nagE gsk gsk CDG10976.1 CDG10976.1 phoR phoR aroL aroL mtnK mtnK chbC chbC chbB chbB cysC cysC barA barA coaE coaE ribF ribF thrB thrB
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CDG14518.1Bifunctional regulatory protein,two-componentsystem sensor kinase and response regulator. (594 aa)
dhaMPTS-dependent dihydroxyacetone kinase,phosphotransferase subunit; Belongs to the PEP-utilizing enzyme family. (476 aa)
CDG14056.1Putative carbohydrate kinase. (310 aa)
scrASucrose-specific PTS system, EIIBC component. (456 aa)
scrKFructokinase; Belongs to the carbohydrate kinase PfkB family. (307 aa)
qseCTwo-component system sensor kinase. (452 aa)
CDG13897.1L-xylulose/3-keto-L-gulonate kinase. (496 aa)
rssASwarming motility regulation two-componentsystem,sensor kinase; Member of the two-component regulatory system RssA/RssB involved in regulation of swarming motility which has been shown to be inhibited by saturated fatty acids. RssA/RssB regulates cellular fatty acid composition, hemolysin production and cell surface topography. RssA/RssB negatively regulates the activity of SlhBA. It can also act as a negative regulator for the control of the swarming initiation. (468 aa)
rbsK-2Putative carbohydrate kinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (308 aa)
creCTwo-component system sensor kinase. (472 aa)
agaZPutative tagatose 6-phosphate kinase. (427 aa)
agaVN-acetylgalactosamine-specific enzyme IIB component of PTS. (158 aa)
CDG13686.1Two-component system sensor kinase. (530 aa)
ppnKProbable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa)
CDG13612.1PTS system, EIIBC component. (455 aa)
glrKTwo-component system sensor kinase. (478 aa)
CDG13550.1Bifunctional protein, two-component sensorkinase and response regulator. (593 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (263 aa)
srlBGlucitol/sorbitol-specific enzyme IIA component of PTS. (120 aa)
srlEGlucitol/sorbitol-specific enzyme IIB component of PTS. (326 aa)
CDG13520.1Putative kinase; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (301 aa)
baeSTwo-component system sensor kinase. (460 aa)
narQNitrate/nitrite sensor protein NarQ. (558 aa)
dhaKPTS-dependent dihydroxyacetone kinase. (333 aa)
CDG13444.1Putative glycerone kinase. (218 aa)
CDG13413.1Two-component system sensor kinase. (441 aa)
crrGlucose-specific enzyme IIA component of PTS. (169 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (320 aa)
CDG13375.1Two-component system sensor kinase. (569 aa)
tctETwo-component system sensor kinase. (472 aa)
CDG13286.1PTS system, IIB component. (93 aa)
CDG13285.1Putative PTS system, IIC component. (459 aa)
rcsCHybrid sensory kinase in two-component regulatory system with RcsB and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (953 aa)
rcsDPhosphotransfer intermediate protein in two-component regulatory system with RcsBC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (900 aa)
ttrSTwo-component system sensor kinase for tetrathionate reductase complex. (587 aa)
fruKFructose-1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. (313 aa)
dhaK-2PTS-dependent dihydroxyacetone kinase,dihydroxyacetone-binding subunit. (368 aa)
rfaEFused heptose 7-phosphatekinase/heptose1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (476 aa)
arcBHybrid sensory histidine kinase in two-component regulatory system with ArcA. (779 aa)
ptsNSugar-specific enzyme IIA component of PTS. (153 aa)
CDG14172.1Putative BglB-family transcriptional antiterminator. (654 aa)
dgkADiacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa)
gntKGluconate kinase 2. (179 aa)
aceKIsocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (595 aa)
slyXHypothetical protein; Belongs to the SlyX family. (75 aa)
prkBProbable phosphoribulokinase. (289 aa)
CDG14395.1Two-component system sensor kinase. (561 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa)
envZSensory histidine kinase in two-component regulatory system with OmpR. (456 aa)
idnKThermoresistant gluconokinase 1. (175 aa)
iolCPutative myo-inositol catabolism carbohydratekinase. (643 aa)
CDG14505.1Putative carbohydrate kinase. (545 aa)
dhaLPTS-dependent dihydroxyacetone kinase,ADP-binding subunit. (210 aa)
kdgK2-dehydro-3-deoxygluconokinase. (310 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
cpxATwo-component system sensor kinase. (464 aa)
glnLNitrogen regulation protein NR(II). (349 aa)
rdoAPutative phosphotransferase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (328 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (308 aa)
CDG14731.1Putative carbohydrate kinase. (321 aa)
mtlAFused mannitol-specific PTS enzymes:IIAcomponents /IIB components/IIC components. (639 aa)
CDG14778.1Two-component system sensor kinase. (391 aa)
bglFBeta-glucoside-specific PTS system, EIIABC components. (620 aa)
uhpBTwo-component system sensor kinase. (514 aa)
wzzEEnterobacterial common antigen polysaccharidechain length modulation protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (351 aa)
ubiBUbiquinone biosynthesis protein; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (543 aa)
coaAPantothenate kinase. (316 aa)
CDG14939.1Two-component system sensor kinase. (424 aa)
pmrBTwo-component system sensor kinase. (353 aa)
treBTrehalose-specific PTS system, EIIBC component. (471 aa)
ascFFused cellobiose/arbutin/salicin-specific PTSenzymes: IIB component/IC component. (468 aa)
nadRBifunctional DNA-binding transcriptional repressor /NMN adenylyltransferase. (424 aa)
fruAFused fructose-specific PTS enzymes: IIBcomponent /IIC component. (561 aa)
sgbKPutative L-xylulose/3-keto-L-gulonate kinase 1; Belongs to the FGGY kinase family. (495 aa)
dgkA_2Putative diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (121 aa)
CDG12850.1Type VI secretion system, serine/threonine protein kinase. (481 aa)
cheAChemotaxis protein CheA; Fused chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY:sensory histidine kinase/signal sensing protein. (672 aa)
cheYChemotaxis regulator transmitting signal to flagellar motor component. (129 aa)
narXNitrate/nitrite sensor protein NarX. (594 aa)
CDG12725.1Tyrosine-protein kinase. (727 aa)
manXFused mannose-specific PTS enzymes:IIAcomponent. (319 aa)
CDG12646.1Hypothetical protein. (546 aa)
pykAPyruvate kinase II; Belongs to the pyruvate kinase family. (480 aa)
CDG12577.1Hypothetical protein. (644 aa)
xylBXylulose kinase. (505 aa)
CDG12484.1Putative carbohydrate kinase; Belongs to the FGGY kinase family. (507 aa)
rstBTwo-component sensor kinase. (434 aa)
CDG12387.1Putative pyridoxine kinase; Belongs to the pyridoxine kinase family. (280 aa)
CDG12290.1Hypothetical protein. (99 aa)
CDG12266.1Putative signaling protein. (626 aa)
malXMaltose-specific PTS system, EIIBC component. (539 aa)
CDG12091.1Putative membrane protein. (146 aa)
strStreptomycin 3''-kinase. (284 aa)
pdxYPyridoxal kinase 2/pyridoxine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (373 aa)
pykFPyruvate kinase I; Belongs to the pyruvate kinase family. (470 aa)
CDG12021.1Hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (273 aa)
phoQSensory histidine kinase in two-component regulatory system with PhoP. (485 aa)
CDG11861.1PTS system, EIIBC component. (519 aa)
CDG11845.1Putative transcriptional regulator. (269 aa)
ispE4-diphosphocytidyl-2-C-methylerythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (288 aa)
dcuSSensory histidine kinase in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration. (537 aa)
thiKPutative thiamin kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (288 aa)
ptsGFused glucose-specific PTS enzymes: IIBcomponent. (477 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (326 aa)
CDG11532.1PTS system, EIIBC component. (518 aa)
wzcTyrosine kinase. (724 aa)
udkUridine/cytidine kinase. (213 aa)
CDG11357.1Two-component sensor kinase. (488 aa)
CDG11356.1Two-component sensor kinase; Member of a two-component regulatory system. (472 aa)
CDG11236.1Putative protein kinase. (282 aa)
lsrKAutoinducer-2 kinase LsrK; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. (521 aa)
CDG11167.1Two-component response regulator. (513 aa)
CDG11151.1Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (305 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (383 aa)
CDG11113.1Bifunctional two-component sensor kinase andresponse regulator. (1066 aa)
kdpDFused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein. (898 aa)
nagEFused N-acetyl glucosamine specific PTS enzyme:IIC, IIB, and IIA components. (678 aa)
gskInosine/guanosine kinase. (434 aa)
CDG10976.1Glycerate kinase; Belongs to the glycerate kinase type-1 family. (387 aa)
phoRPhosphate regulon sensor protein PhoR. (438 aa)
aroLShikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa)
mtnKPutative methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (399 aa)
chbCN,N'-diacetylchitobiose-specific enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (453 aa)
chbBN,N'-diacetylchitobiose-specific enzyme IIB component of PTS. (105 aa)
cysCAdenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (208 aa)
barAHybrid sensory histidine kinase in two-component regulatory system with UvrY. (908 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
ribFBifunctional riboflavin kinase/FAD synthetase; Belongs to the ribF family. (312 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
Your Current Organism:
Serratia marcescens
NCBI taxonomy Id: 273526
Other names: S. marcescens subsp. marcescens Db11, Serratia marcescens subsp. marcescens Db11, Serratia marcescens subsp. marcescens str. Db11, Serratia marcescens subsp. marcescens strain Db11
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