(87 nodes) Microbial metabolism in diverse environments, and Pyruvate network (Thermococcus thioreducens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	SEV80996.1	Indolepyruvate ferredoxin oxidoreductase, subunit iorB. (204 aa)
	SEV81010.1	Indolepyruvate ferredoxin oxidoreductase, subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (646 aa)
	SEV81020.1	Hypothetical protein. (152 aa)
	SEV81047.1	Acetyl coenzyme A synthetase (ADP forming), alpha domain-containing protein. (458 aa)
	SEV81068.1	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily. (224 aa)
	SEV81077.1	Putative cell wall-binding protein. (334 aa)
	rbcL	Ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (444 aa)
	SEV82143.1	Glycerate 2-kinase. (447 aa)
	SEV82330.1	Kynurenine formamidase. (189 aa)
	SEV82874.1	methylmalonyl-CoA mutase. (562 aa)
	SEV83061.1	acetyl-CoA synthetase (ADP-forming). (464 aa)
	SEV83361.1	Putative hydrolase. (218 aa)
	SEV83372.1	methylmalonyl-CoA mutase, C-terminal domain. (143 aa)
	SEV83385.1	LAO/AO transport system kinase. (319 aa)
	SEV83397.1	methylmalonyl-CoA epimerase. (133 aa)
	SEV83410.1	Protein of unknown function. (141 aa)
	SEV84008.1	ADP-dependent phosphofructokinase. (459 aa)
	SEV84193.1	acetyl-CoA synthetase (ADP-forming) beta subunit. (238 aa)
	SEV84203.1	Acetyl coenzyme A synthetase (ADP forming), alpha domain-containing protein. (472 aa)
	pgk	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (409 aa)
	gyaR	Glyoxylate reductase. (334 aa)
	SEV85927.1	Pyruvate carboxylase subunit B. (594 aa)
	SEV85939.1	Fructose-bisphosphate aldolase. (281 aa)
	SEV86561.1	2-oxoglutarate ferredoxin oxidoreductase subunit beta. (292 aa)
	SEV86576.1	2-oxoglutarate ferredoxin oxidoreductase subunit alpha. (570 aa)
	SEV86589.1	Nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa)
	SEV88226.1	Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
	gap	Glyceraldehyde 3-phosphate dehydrogenase (NAD(P)+). (334 aa)
	SEV92266.1	Hypothetical protein. (197 aa)
	SEV92313.1	2-oxoglutarate ferredoxin oxidoreductase, delta subunit. (104 aa)
	SEV92331.1	2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (396 aa)
	SEV92350.1	2-oxoglutarate ferredoxin oxidoreductase, beta subunit. (284 aa)
	SEV92366.1	2-oxoglutarate ferredoxin oxidoreductase, gamma subunit. (172 aa)
	SEV92384.1	Protein of unknown function. (113 aa)
	SEV92398.1	Uncharacterized protein YuzE. (68 aa)
	SEV92414.1	2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (382 aa)
	SEV92430.1	2-oxoglutarate ferredoxin oxidoreductase, beta subunit. (281 aa)
	SEV92443.1	2-oxoglutarate ferredoxin oxidoreductase, gamma subunit. (186 aa)
	SEV92459.1	Hypothetical protein; Belongs to the UPF0127 family. (156 aa)
	SEV92692.1	Hypothetical protein. (254 aa)
	SEV92706.1	Predicted nucleic acid-binding protein, contains PIN domain. (137 aa)
	SEV92722.1	Transcriptional regulator, AbrB family. (84 aa)
	SEV92737.1	Putative aminopeptidase FrvX. (331 aa)
	SEV92753.1	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)
	SEV95049.1	Aldehyde:ferredoxin oxidoreductase. (618 aa)
	SEV95068.1	Aldo/keto reductase. (273 aa)
	SEV95086.1	Phosphoglycerate mutase. (411 aa)
	eno	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
	tpiA	Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa)
	SEW08598.1	Predicted transcriptional regulator, contains C-terminal CBS domains. (391 aa)
	SEW08866.1	Phosphoglycolate phosphatase; Catalyzes the dephosphorylation of 2-phosphoglycolate. (245 aa)
	SEW09100.1	3-hexulose-6-phosphate synthase. (406 aa)
	SEW09261.1	acetyl-CoA synthetase (ADP-forming) beta subunit. (232 aa)
	pckG	Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (625 aa)
	SEW10597.1	L-alanine aminotransferase apoenzyme. (399 aa)
	glkA	ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ADP as the phosphate donor. (454 aa)
	SEW10928.1	Glucose-6-phosphate isomerase. (189 aa)
	SEW11353.1	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (784 aa)
	SEW12407.1	Enolase. (341 aa)
	SEW13806.1	Hypothetical protein. (287 aa)
	SEW13823.1	Hypothetical protein. (165 aa)
	SEW13841.1	DNA replication factor GINS. (164 aa)
	SEW13890.1	methylmalonyl-CoA decarboxylase alpha subunit. (522 aa)
	SEW13911.1	Sodium pump decarboxylases, gamma subunit. (126 aa)
	SEW13927.1	Biotin carboxyl carrier protein. (154 aa)
	SEW13947.1	Oxaloacetate decarboxylase, beta subunit. (401 aa)
	SEW13963.1	CBS domain-containing protein. (281 aa)
	SEW14368.1	Indolepyruvate ferredoxin oxidoreductase alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (634 aa)
	SEW20926.1	Indolepyruvate ferredoxin oxidoreductase beta subunit. (194 aa)
	lysS	lysyl-tRNA synthetase, class I; Belongs to the class-I aminoacyl-tRNA synthetase family. (526 aa)
	SEW20948.1	Hypothetical protein. (294 aa)
	SEW20957.1	Hypothetical protein. (203 aa)
	SEW22036.1	Malate dehydrogenase (oxaloacetate-decarboxylating). (426 aa)
	SEW22049.1	Fumarase, class I beta subunit. (174 aa)
	SEW22065.1	Fumarase, class I alpha subunit. (283 aa)
	SEW22090.1	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (307 aa)
	SEW22262.1	Ketoisovalerate ferredoxin oxidoreductase, gamma subunit /pyruvate ferredoxin oxidoreductase, gamma subunit. (185 aa)
	vorD	Ketoisovalerate ferredoxin oxidoreductase, delta subunit. (105 aa)
	porA	Ketoisovalerate ferredoxin oxidoreductase, alpha subunit. (396 aa)
	SEW22302.1	Ketoisovalerate ferredoxin oxidoreductase, beta subunit. (311 aa)
	porD	Pyruvate ferredoxin oxidoreductase, delta subunit. (105 aa)
	porA-2	Pyruvate ferredoxin oxidoreductase, alpha subunit. (394 aa)
	SEW22349.1	Pyruvate ferredoxin oxidoreductase, beta subunit. (331 aa)
	SEW22490.1	Acylphosphatase. (91 aa)
	fbp	Fructose-bisphosphate aldolase /D-fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (375 aa)
	SEW22644.1	Glyceraldehyde-3-phosphate ferredoxin oxidoreductase. (652 aa)
	SEW23792.1	L-fuculose-phosphate aldolase. (184 aa)

Your Current Organism:

Thermococcus thioreducens

NCBI taxonomy Id: 277988
Other names: ATCC BAA-394, DSM 14981, JCM 12859, T. thioreducens, Thermococcus sp. OGL-20P, Thermococcus thioreducens Pikuta et al. 2007, strain OGL-20P

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEV80996.1	SEV81010.1	SAMN05216170_0033	SAMN05216170_0034	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Indolepyruvate ferredoxin oxidoreductase, subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	0.968
SEV80996.1	SEV81020.1	SAMN05216170_0033	SAMN05216170_0035	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Hypothetical protein.	0.804
SEV80996.1	SEV81047.1	SAMN05216170_0033	SAMN05216170_0037	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Acetyl coenzyme A synthetase (ADP forming), alpha domain-containing protein.	0.638
SEV80996.1	SEV81068.1	SAMN05216170_0033	SAMN05216170_0038	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily.	0.541
SEV80996.1	SEV86561.1	SAMN05216170_0033	SAMN05216170_0494	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	2-oxoglutarate ferredoxin oxidoreductase subunit beta.	0.675
SEV80996.1	SEV86576.1	SAMN05216170_0033	SAMN05216170_0495	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.517
SEV80996.1	SEV92331.1	SAMN05216170_0033	SAMN05216170_0888	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.	0.524
SEV80996.1	SEV92350.1	SAMN05216170_0033	SAMN05216170_0889	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	2-oxoglutarate ferredoxin oxidoreductase, beta subunit.	0.675
SEV80996.1	SEV92414.1	SAMN05216170_0033	SAMN05216170_0893	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.	0.524
SEV80996.1	SEV92430.1	SAMN05216170_0033	SAMN05216170_0894	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	2-oxoglutarate ferredoxin oxidoreductase, beta subunit.	0.675
SEV80996.1	SEW14368.1	SAMN05216170_0033	SAMN05216170_1854	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Indolepyruvate ferredoxin oxidoreductase alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	0.834
SEV80996.1	SEW22302.1	SAMN05216170_0033	SAMN05216170_2221	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Ketoisovalerate ferredoxin oxidoreductase, beta subunit.	0.668
SEV80996.1	SEW22349.1	SAMN05216170_0033	SAMN05216170_2224	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Pyruvate ferredoxin oxidoreductase, beta subunit.	0.668
SEV80996.1	porA	SAMN05216170_0033	SAMN05216170_2220	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Ketoisovalerate ferredoxin oxidoreductase, alpha subunit.	0.511
SEV80996.1	porA-2	SAMN05216170_0033	SAMN05216170_2223	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	Pyruvate ferredoxin oxidoreductase, alpha subunit.	0.511
SEV81010.1	SEV80996.1	SAMN05216170_0034	SAMN05216170_0033	Indolepyruvate ferredoxin oxidoreductase, subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	Indolepyruvate ferredoxin oxidoreductase, subunit iorB.	0.968
SEV81010.1	SEV81020.1	SAMN05216170_0034	SAMN05216170_0035	Indolepyruvate ferredoxin oxidoreductase, subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	Hypothetical protein.	0.804
SEV81010.1	SEV81047.1	SAMN05216170_0034	SAMN05216170_0037	Indolepyruvate ferredoxin oxidoreductase, subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	Acetyl coenzyme A synthetase (ADP forming), alpha domain-containing protein.	0.724
SEV81010.1	SEV81068.1	SAMN05216170_0034	SAMN05216170_0038	Indolepyruvate ferredoxin oxidoreductase, subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily.	0.541
SEV81010.1	SEV92366.1	SAMN05216170_0034	SAMN05216170_0890	Indolepyruvate ferredoxin oxidoreductase, subunit iorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	2-oxoglutarate ferredoxin oxidoreductase, gamma subunit.	0.457

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