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| | tbp | TATA binding protein of transcription factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (190 aa) |
| | SEV80996.1 | Indolepyruvate ferredoxin oxidoreductase, subunit iorB. (204 aa) |
| | SEV81128.1 | Creatinine amidohydrolase. (238 aa) |
| | SEV81369.1 | Sulfide dehydrogenase (flavoprotein) subunit SudB. (288 aa) |
| | ribL | FMN adenylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (151 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa) |
| | tfb | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (303 aa) |
| | SEV81931.1 | Archaeal histone. (67 aa) |
| | tdk | Thymidine kinase. (196 aa) |
| | SEV82510.1 | Nicotinamide-nucleotide adenylyltransferase. (187 aa) |
| | SEV82708.1 | Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase. (249 aa) |
| | mptE | Hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (235 aa) |
| | SEV82760.1 | Molybdopterin-guanine dinucleotide biosynthesis protein B. (244 aa) |
| | tfb-2 | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (299 aa) |
| | SEV83132.1 | Molybdopterin molybdochelatase. (400 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (455 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (386 aa) |
| | SEV84656.1 | Molybdopterin-guanine dinucleotide biosynthesis protein A. (212 aa) |
| | SEV84710.1 | Uncharacterized protein. (1498 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (170 aa) |
| | SEV85512.1 | Nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (180 aa) |
| | SEV85560.1 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (451 aa) |
| | SEV85586.1 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (152 aa) |
| | SEV85776.1 | UDP-glucose 4-epimerase. (310 aa) |
| | SEV85789.1 | Adenylosuccinate synthetase. (339 aa) |
| | thiI-2 | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (363 aa) |
| | SEV86803.1 | Indolepyruvate ferredoxin oxidoreductase beta subunit. (200 aa) |
| | rpoM | DNA-directed RNA polymerase, subunit M; Manually curated; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (110 aa) |
| | SEV88043.1 | Phosphopantothenate-cysteine ligase. (404 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (224 aa) |
| | SEV88282.1 | Molybdopterin synthase sulfur carrier subunit. (93 aa) |
| | mptA | GTP cyclohydrolase I; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (267 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (285 aa) |
| | moaC | Cyclic pyranopterin monophosphate synthase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (160 aa) |
| | SEV89613.1 | 23S rRNA (adenine2503-C2)-methyltransferase. (315 aa) |
| | SEV89861.1 | Molybdopterin molybdochelatase. (396 aa) |
| | SEV89876.1 | Molybdopterin adenylyltransferase. (171 aa) |
| | SEV89942.1 | TIGR00303 family protein. (335 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa) |
| | SEV89980.1 | Adenosylcobinamide-phosphate guanylyltransferase. (179 aa) |
| | cobS | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (231 aa) |
| | cobD | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (294 aa) |
| | SEV90400.1 | Adenylate cyclase, class 2. (171 aa) |
| | SEV90972.1 | Competence/damage-inducible protein cinA; Belongs to the CinA family. (252 aa) |
| | SEV91063.1 | ATP:cob(I)alamin adenosyltransferase. (171 aa) |
| | SEV91776.1 | IMP cyclohydrolase. (195 aa) |
| | SEV91789.1 | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. (310 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (219 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (431 aa) |
| | thi4 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (251 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (263 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (205 aa) |
| | SEV91905.1 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (430 aa) |
| | SEV92094.1 | Hypothetical protein. (216 aa) |
| | SEV92366.1 | 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit. (172 aa) |
| | SEV92443.1 | 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit. (186 aa) |
| | SEV92520.1 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. (115 aa) |
| | SEV92863.1 | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (180 aa) |
| | ribK | CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (212 aa) |
| | SEV93169.1 | Sulfhydrogenase gamma subunit. (294 aa) |
| | queE | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (253 aa) |
| | rpoP | DNA-directed RNA polymerase, subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (49 aa) |
| | SEV95138.1 | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (249 aa) |
| | thiL | Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (330 aa) |
| | SEV96046.1 | DNA-directed RNA polymerase, subunit F. (120 aa) |
| | SEV96498.1 | Dihydropteroate synthase. (272 aa) |
| | SEV96754.1 | Molybdopterin synthase subunit MoaD. (88 aa) |
| | SEV96811.1 | Molybdopterin synthase subunit MoaE. (143 aa) |
| | SEV97043.1 | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | SEW04414.1 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1291 aa) |
| | SEW04467.1 | Hypothetical protein. (153 aa) |
| | SEW04954.1 | Phosphoribosyl 1,2-cyclic phosphodiesterase. (271 aa) |
| | priL | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (401 aa) |
| | priS | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (357 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (253 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (410 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (233 aa) |
| | atpD | V/A-type H+-transporting ATPase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (217 aa) |
| | atpB | V/A-type H+-transporting ATPase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | SEW05588.1 | V/A-type H+-transporting ATPase subunit A. (585 aa) |
| | atpF | V/A-type H+-transporting ATPase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (102 aa) |
| | atpC | V/A-type H+-transporting ATPase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (366 aa) |
| | atpE | V/A-type H+-transporting ATPase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (203 aa) |
| | SEW06103.1 | 4-aminobutyrate aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa) |
| | mfnA | Tyrosine decarboxylase / aspartate 1-decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (385 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (257 aa) |
| | polB | DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (702 aa) |
| | polC | DNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1297 aa) |
| | SEW07722.1 | Pantetheine-phosphate adenylyltransferase. (160 aa) |
| | PpnK | NAD+ kinase. (278 aa) |
| | SEW08275.1 | DNA-directed RNA polymerase subunit L. (95 aa) |
| | SEW08504.1 | Adenylate cyclase, class 2. (184 aa) |
| | SEW08636.1 | Glucose-1-phosphate thymidylyltransferase; Bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase. (419 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa) |
| | SEW08992.1 | Transcription antitermination factor NusA, contains S1 and KH domains. (170 aa) |
| | SEW09100.1 | 3-hexulose-6-phosphate synthase. (406 aa) |
| | SEW09135.1 | UPF0148 protein. (110 aa) |
| | dcd | dCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (156 aa) |
| | SEW09902.1 | 5S rRNA maturation endonuclease (Ribonuclease M5), contains TOPRIM domain; Belongs to the UPF0292 family. (133 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (461 aa) |
| | tmk | Thymidylate kinase. (207 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (82 aa) |
| | SEW10357.1 | DNA-directed RNA polymerase, subunit B. (1122 aa) |
| | SEW10381.1 | DNA-directed RNA polymerase, subunit A'. (905 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (391 aa) |
| | nusA | N utilization substance protein A; Participates in transcription termination. Belongs to the NusA family. (145 aa) |
| | cpsB | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (460 aa) |
| | mobA | Molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (193 aa) |
| | SEW11223.1 | Predicted polyphosphate-or ATP-dependent NAD kinase. (377 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (222 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (441 aa) |
| | SEW12061.1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (278 aa) |
| | SEW12128.1 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (267 aa) |
| | SEW12249.1 | Adenine phosphoribosyltransferase. (238 aa) |
| | rpoK | DNA-directed RNA polymerase, subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (57 aa) |
| | rpoN | DNA-directed RNA polymerase, subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (65 aa) |
| | SEW12517.1 | DNA-directed RNA polymerase, subunit D. (263 aa) |
| | cmk | Cytidylate kinase. (193 aa) |
| | adkA | Adenylate kinase; Belongs to the archaeal adenylate kinase family. (196 aa) |
| | SEW13455.1 | Sulfhydrogenase gamma subunit. (291 aa) |
| | SEW14811.1 | DNA polymerase I. (1311 aa) |
| | SEW16242.1 | DNA-directed RNA polymerase subunit E'. (186 aa) |
| | SEW16272.1 | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (177 aa) |
| | guaAA | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (189 aa) |
| | guaAB | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (307 aa) |
| | purP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (331 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (713 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (223 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (80 aa) |
| | SEW16730.1 | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. (380 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (442 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (143 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (430 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (334 aa) |
| | purC-2 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (244 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (444 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (335 aa) |
| | SEW16944.1 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (277 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (302 aa) |
| | SEW16990.1 | L-aspartate oxidase. (466 aa) |
| | SEW17001.1 | Inosine-5'-monophosphate dehydrogenase. (486 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa) |
| | pyrD | Dihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (301 aa) |
| | queC | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (239 aa) |
| | SEW20477.1 | Tungsten cofactor oxidoreducase radical SAM maturase. (376 aa) |
| | SEW20583.1 | Nicotinate phosphoribosyltransferase. (390 aa) |
| | SEW20653.1 | ferredoxin--NADP+ reductase. (282 aa) |
| | SEW20665.1 | Pantothenate synthetase. (262 aa) |
| | SEW20926.1 | Indolepyruvate ferredoxin oxidoreductase beta subunit. (194 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (281 aa) |
| | moaA | Cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (308 aa) |
| | SEW21201.1 | 2-amino-3-ketobutyrate coenzyme A ligase. (395 aa) |
| | pyrB | Aspartate carbamoyltransferase. (311 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa) |
| | SEW22113.1 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa) |
| | SEW22262.1 | Ketoisovalerate ferredoxin oxidoreductase, gamma subunit /pyruvate ferredoxin oxidoreductase, gamma subunit. (185 aa) |
| | vorD | Ketoisovalerate ferredoxin oxidoreductase, delta subunit. (105 aa) |
| | porD | Pyruvate ferredoxin oxidoreductase, delta subunit. (105 aa) |
| | tfe | Transcription factor E (TFE); Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. [...] (178 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (183 aa) |
| | lig | DNA ligase-1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. (559 aa) |
| | SEW22938.1 | Pantothenate kinase. (300 aa) |
| | SEW23063.1 | Hypothetical protein. (146 aa) |
| | SEW23823.1 | cob(I)yrinic acid a,c-diamide adenosyltransferase. (186 aa) |
| | SEW24318.1 | Membrane bound hydrogenase subunit mbhJ. (171 aa) |
| | SEW24347.1 | Membrane bound hydrogenase subunit mbhL. (431 aa) |
| | SEW24549.1 | Membrane-bound hydrogenase subunit alpha. (412 aa) |
