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purQ purQ asnA asnA cysS cysS gltX gltX proC proC lysS lysS alr alr pyrG pyrG PEPE_1627 PEPE_1627 PEPE_1628 PEPE_1628 arcA arcA PEPE_1630 PEPE_1630 arcB arcB PEPE_1709 PEPE_1709 PEPE_1739 PEPE_1739 dsdA dsdA PEPE_0076 PEPE_0076 PEPE_0107 PEPE_0107 PEPE_0111 PEPE_0111 asd asd dapB dapB dapA dapA PEPE_0134 PEPE_0134 dapH dapH lysA lysA PEPE_0137 PEPE_0137 dapF dapF PEPE_0166 PEPE_0166 PEPE_0167 PEPE_0167 ptcA ptcA PEPE_0192 PEPE_0192 tyrS tyrS trpS trpS metG metG PEPE_0301 PEPE_0301 pyrB pyrB carA carA carB carB guaA guaA glmS glmS PEPE_0488 PEPE_0488 PEPE_0496 PEPE_0496 asnS asnS leuS leuS PEPE_0659 PEPE_0659 argS argS argR argR PEPE_0684 PEPE_0684 thrS thrS pheS pheS pheT pheT PEPE_0739 PEPE_0739 folD folD argR-2 argR-2 proS proS carA-2 carA-2 PEPE_0944 PEPE_0944 PEPE_1052 PEPE_1052 PEPE_1069 PEPE_1069 glyS glyS glyQ glyQ aspS aspS hisS hisS dtd dtd PEPE_1175 PEPE_1175 ileS ileS alaS alaS valS valS PEPE_1294 PEPE_1294 glyA glyA PEPE_1333 PEPE_1333 serS serS purF purF
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (224 aa)
asnAAspartate-ammonia ligase. (335 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (470 aa)
gltXglutamate--tRNA(Gln) ligase / glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (495 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (263 aa)
lysSLysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (498 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (374 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa)
PEPE_1627Arginine:ornithine antiporter, APA family; TC 2.A.3.2.3. (473 aa)
PEPE_1628Arginine:ornithine antiporter, APA family; TC 2.A.3.2.3. (472 aa)
arcAArginine deiminase. (407 aa)
PEPE_1630Carbamate kinase; Belongs to the carbamate kinase family. (309 aa)
arcBOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (333 aa)
PEPE_1709Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta. (228 aa)
PEPE_1739Predicted membrane protein. (242 aa)
dsdAD-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (432 aa)
PEPE_0076Threonine dehydrogenase related Zn-dependent dehydrogenase. (347 aa)
PEPE_0107Histidinol phosphatase related hydrolase of the PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (266 aa)
PEPE_0111Acetylornithine deacetylase. (383 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (254 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
PEPE_0134Metal-dependent amidase/aminoacylase/carboxypeptidase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (384 aa)
dapHTetrahydrodipicolinate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (236 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
PEPE_0137Aspartate kinase; Belongs to the aspartokinase family. (459 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (329 aa)
PEPE_0166L-alanine dehydrogenase. (368 aa)
PEPE_0167L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (351 aa)
ptcAPutrescine carbamoyltransferase; Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. (344 aa)
PEPE_0192Carbamate kinase; Belongs to the carbamate kinase family. (314 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (417 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (342 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (673 aa)
PEPE_0301Asparaginase. (323 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (361 aa)
carBCarbamoyl-phosphate synthase large subunit. (1057 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa)
glmSGlutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa)
PEPE_0488Cysteine desulfurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (391 aa)
PEPE_0496Methionine synthase II (cobalamin-independent). (372 aa)
asnSasparaginyl-tRNA synthetase. (464 aa)
leuSleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (805 aa)
PEPE_0659Asparagine synthase (glutamine-hydrolyzing). (626 aa)
argSarginyl-tRNA synthetase. (562 aa)
argRTranscriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (152 aa)
PEPE_0684EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (210 aa)
thrSSer-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (648 aa)
pheSphenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (355 aa)
pheTphenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (809 aa)
PEPE_0739L-glutamine synthetase. (446 aa)
folDMethenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
argR-2Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (152 aa)
proSProlyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (571 aa)
carA-2Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (359 aa)
PEPE_0944Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (818 aa)
PEPE_1052Acetyltransferase, GNAT family. (164 aa)
PEPE_1069Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
glySglycyl-tRNA synthetase beta chain. (690 aa)
glyQglycyl-tRNA synthetase alpha chain. (299 aa)
aspSaspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (593 aa)
hisShistidyl-tRNA synthetase. (424 aa)
dtdD-Tyr-tRNAtyr deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa)
PEPE_1175Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (233 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (933 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (881 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (888 aa)
PEPE_1294Cysteine sulfinate desulfinase/cysteine desulfurase related enzyme. (384 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa)
PEPE_1333Predicted glutamine amidotransferase. (234 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (489 aa)
Your Current Organism:
Pediococcus pentosaceus
NCBI taxonomy Id: 278197
Other names: P. pentosaceus ATCC 25745, Pediococcus pentosaceus ATCC 25745, Pediococcus pentosaceus str. ATCC 25745, Pediococcus pentosaceus strain ATCC 25745
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