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rpsU rpsU PEPE_1112 PEPE_1112 PEPE_1113 PEPE_1113 aspS aspS hisS hisS tuf tuf rpsO rpsO rpsT rpsT PEPE_1148 PEPE_1148 PEPE_1156 PEPE_1156 def def PEPE_1161 PEPE_1161 ileS ileS murD murD murG murG mraY mraY PEPE_1243 PEPE_1243 efp-2 efp-2 murI murI alaS alaS dinB dinB valS valS rpsD rpsD ddl ddl prfA prfA tdk tdk PEPE_1332 PEPE_1332 PEPE_1333 PEPE_1333 PEPE_1358 PEPE_1358 gatB gatB gatA gatA gatC gatC rpsI rpsI rplM rplM rplQ rplQ rpoA rpoA rpsK rpsK rpsM rpsM rpmJ rpmJ infA infA rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsZ rpsZ rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ fusA fusA rpsG rpsG rpsL rpsL rpoC rpoC rpoB rpoB serS serS PEPE_1479 PEPE_1479 dnaX dnaX rplL rplL rplJ rplJ rplA rplA rplK rplK nusG nusG rpmG2 rpmG2 PEPE_1497 PEPE_1497 cysS cysS gltX gltX PEPE_1526 PEPE_1526 lysS lysS PEPE_1548 PEPE_1548 pth pth PEPE_1555 PEPE_1555 murF murF rpmE2 rpmE2 rho rho murA murA rpoE rpoE PEPE_1587 PEPE_1587 dltC dltC PEPE_1589 PEPE_1589 dltA dltA PEPE_1603 PEPE_1603 PEPE_1608 PEPE_1608 PEPE_1610 PEPE_1610 PEPE_1611 PEPE_1611 PEPE_1704 PEPE_1704 PEPE_1709 PEPE_1709 PEPE_1715 PEPE_1715 PEPE_1740 PEPE_1740 rpmH rpmH PEPE_0543 PEPE_0543 asnS asnS PEPE_0565 PEPE_0565 PEPE_0566 PEPE_0566 PEPE_0567 PEPE_0567 PEPE_0568 PEPE_0568 PEPE_0569 PEPE_0569 PEPE_0571 PEPE_0571 PEPE_0574 PEPE_0574 PEPE_0575 PEPE_0575 PEPE_0576 PEPE_0576 PEPE_0577 PEPE_0577 PEPE_0602 PEPE_0602 prfC prfC PEPE_0604 PEPE_0604 leuS leuS murE murE argS argS PEPE_0684 PEPE_0684 murC murC polA polA PEPE_0692 PEPE_0692 thrS thrS infC infC rpmI rpmI rplT rplT rpmF rpmF pheS pheS pheT pheT mltG mltG PEPE_0216 PEPE_0216 rpsN rpsN tyrS tyrS trpS trpS metG metG glmU glmU PEPE_0320 PEPE_0320 PEPE_0351 PEPE_0351 PEPE_0358 PEPE_0358 PEPE_0367 PEPE_0367 prfB prfB PEPE_0105 PEPE_0105 PEPE_0069 PEPE_0069 PEPE_0012 PEPE_0012 rplI rplI rpsR rpsR rpsF rpsF PEPE_0002 PEPE_0002 PEPE_0114 PEPE_0114 lgt lgt PEPE_0457 PEPE_0457 smpB smpB PEPE_0472 PEPE_0472 murB murB PEPE_0727 PEPE_0727 rpmG1 rpmG1 PEPE_0760 PEPE_0760 rplU rplU rpmA rpmA efp efp nusB nusB rpoZ rpoZ priA priA fmt fmt rpmB rpmB rpsP rpsP rplS rplS rpsB rpsB tsf tsf frr frr proS proS polC polC nusA nusA infB infB lepA lepA PEPE_0918 PEPE_0918 PEPE_0930 PEPE_0930 pyrR pyrR PEPE_0945 PEPE_0945 PEPE_0972 PEPE_0972 PEPE_1079 PEPE_1079 PEPE_1094 PEPE_1094 sigA sigA dnaG dnaG glyS glyS glyQ glyQ
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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rpsUSSU ribosomal protein S21P; Belongs to the bacterial ribosomal protein bS21 family. (61 aa)
PEPE_1112CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase. (403 aa)
PEPE_1113CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase. (385 aa)
aspSaspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (593 aa)
hisShistidyl-tRNA synthetase. (424 aa)
tufTranslation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa)
rpsOSSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
rpsTSSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (84 aa)
PEPE_1148DNA polymerase III, delta subunit. (339 aa)
PEPE_1156Stress response membrane GTPase. (614 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (184 aa)
PEPE_1161RNA binding protein, RRM domain. (71 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (933 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (455 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (362 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (318 aa)
PEPE_1243Nucleotidyltransferase/DNA polymerase for DNA repair; Belongs to the DNA polymerase type-Y family. (429 aa)
efp-2Translation initiation factor 5A precursor (eIF-5A); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (265 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (881 aa)
dinBNucleotidyltransferase/DNA polymerase for DNA repair; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (374 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (888 aa)
rpsDSSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (202 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (351 aa)
prfABacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (359 aa)
tdkThymidine kinase. (197 aa)
PEPE_1332UDP-N-acetylmuramyl tripeptide synthase. (448 aa)
PEPE_1333Predicted glutamine amidotransferase. (234 aa)
PEPE_1358Hypothetical protein. (382 aa)
gatBaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (475 aa)
gatAaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (486 aa)
gatCaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (104 aa)
rpsISSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (130 aa)
rplMLSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
rplQLSU ribosomal protein L17P. (127 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (314 aa)
rpsKSSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsMSSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpmJLSU ribosomal protein L36P; Belongs to the bacterial ribosomal protein bL36 family. (39 aa)
infABacterial translation initiation factor 1 (bIF-1); One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
rplOLSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpmDLSU ribosomal protein L30P. (60 aa)
rpsESSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (167 aa)
rplRLSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rplFLSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rpsHSSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsZSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplELSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rplXLSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (103 aa)
rplNLSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQSSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (88 aa)
rpmCLSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (64 aa)
rplPLSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa)
rpsCSSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (223 aa)
rplVLSU ribosomal protein L22P; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (118 aa)
rpsSSSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplBLSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (282 aa)
rplWLSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa)
rplDLSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (207 aa)
rplCLSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (210 aa)
rpsJSSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
fusATranslation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (697 aa)
rpsGSSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLSSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. (137 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1212 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1202 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
PEPE_1479DNA polymerase III, delta prime subunit. (338 aa)
dnaXDNA polymerase III, gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (581 aa)
rplLLSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (121 aa)
rplJLSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (168 aa)
rplALSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplKLSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
nusGTranscription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (181 aa)
rpmG2LSU ribosomal protein L33P; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
PEPE_1497RNA polymerase, sigma 30 subunit, SigH. (197 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (470 aa)
gltXglutamate--tRNA(Gln) ligase / glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (495 aa)
PEPE_1526N-acetylmannosaminyltransferase; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. (243 aa)
lysSLysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (498 aa)
PEPE_1548RNA binding protein (S1 domain). (168 aa)
pthpeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (185 aa)
PEPE_1555Peptidoglycan transpeptidase precursor, ErfK-YbiS-YhnG family. (467 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (460 aa)
rpmE2LSU ribosomal protein L31P. (81 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (428 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
rpoEDNA-directed RNA polymerase, delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (178 aa)
PEPE_1587D-alanyl transfer protein. (428 aa)
dltCD-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (77 aa)
PEPE_1589D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. (397 aa)
dltAD-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] (508 aa)
PEPE_1603CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase. (393 aa)
PEPE_1608CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase. (1663 aa)
PEPE_1610Glycosyltransferase related enzyme. (308 aa)
PEPE_1611Conserved membrane protein, GtcA family. (139 aa)
PEPE_1704Glycosyltransferase related enzyme. (365 aa)
PEPE_1709Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta. (228 aa)
PEPE_1715D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (418 aa)
PEPE_1740peptidoglycan-N-acetylmuramate O-acetyltransferase. (644 aa)
rpmHLSU ribosomal protein L34P; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
PEPE_0543LPS biosynthesis protein. (270 aa)
asnSasparaginyl-tRNA synthetase. (464 aa)
PEPE_0565Capsular polysaccharide biosynthesis protein. (261 aa)
PEPE_0566Tyrosine-protein kinase (capsular polysaccharide biosynthesis). (243 aa)
PEPE_0567Capsular polysaccharide biosynthesis protein. (263 aa)
PEPE_0568Lipopolysaccharide synthesis sugar transferase. (217 aa)
PEPE_0569Lipopolysaccharide biosynthesis glycosyltransferase. (260 aa)
PEPE_0571Glycosyltransferase. (332 aa)
PEPE_0574UDP-galactopyranose mutase. (372 aa)
PEPE_0575Polysaccharide Transporter, PST family. (474 aa)
PEPE_0576Glycosyltransferase related enzyme. (322 aa)
PEPE_0577Fucose 4-O-acetylase related acetyltransferase. (334 aa)
PEPE_0602Glycerol-3-phosphate cytidylyltransferase. (134 aa)
prfCBacterial peptide chain release factor 3 (bRF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (522 aa)
PEPE_0604Phosphoglycerol transferase related protein, alkaline phosphatase superfamily. (724 aa)
leuSleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (805 aa)
murEUDP-N-acetylmuramyl tripeptide synthase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the MurCDEF family. MurE subfamily. (507 aa)
argSarginyl-tRNA synthetase. (562 aa)
PEPE_0684EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (210 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (436 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (887 aa)
PEPE_0692Replicative DNA helicase loader DnaB. (456 aa)
thrSSer-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (648 aa)
infCBacterial translation initiation factor 3 (bIF-3); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (166 aa)
rpmILSU ribosomal protein L35P; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplTLSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
rpmFLSU ribosomal protein L32P; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
pheSphenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (355 aa)
pheTphenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (809 aa)
mltGPredicted periplasmic solute-binding protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (388 aa)
PEPE_0216Lipopolysaccharide biosynthesis glycosyltransferase. (549 aa)
rpsNSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (89 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (417 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (342 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (673 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (467 aa)
PEPE_0320Hypothetical protein. (495 aa)
PEPE_0351Hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (166 aa)
PEPE_0358Hypothetical protein. (221 aa)
PEPE_0367Phosphoglycerol transferase related protein, alkaline phosphatase superfamily. (718 aa)
prfBBacterial peptide chain release factor 2 (bRF-2); Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (343 aa)
PEPE_0105Glycosyltransferase. (441 aa)
PEPE_0069Hypothetical protein. (243 aa)
PEPE_0012Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (465 aa)
rplILSU ribosomal protein L9P; Binds to the 23S rRNA. (150 aa)
rpsRSSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (78 aa)
rpsFSSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (94 aa)
PEPE_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (379 aa)
PEPE_0114RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24-like protein; Belongs to the sigma-70 factor family. (193 aa)
lgtProlipoprotein diacylglyceryltransferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (278 aa)
PEPE_0457RNA polymerase, sigma 54 subunit, RpoN/SigL. (438 aa)
smpBSsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (155 aa)
PEPE_0472DNA polymerase III, epsilon subunit related 3'-5' exonuclease. (178 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (300 aa)
PEPE_0727Cell elongation-specific peptidoglycan D,D-transpeptidase. (696 aa)
rpmG1LSU ribosomal protein L33P; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
PEPE_0760Replicative DNA helicase. (415 aa)
rplULSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
rpmALSU ribosomal protein L27P; Belongs to the bacterial ribosomal protein bL27 family. (95 aa)
efpTranslation elongation factor P (EF-P); Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (187 aa)
nusBNusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (133 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (69 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (806 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (320 aa)
rpmBLSU ribosomal protein L28P; Belongs to the bacterial ribosomal protein bL28 family. (61 aa)
rpsPSSU ribosomal protein S16P; Belongs to the bacterial ribosomal protein bS16 family. (90 aa)
rplSLSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (119 aa)
rpsBSSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (260 aa)
tsfTranslation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (292 aa)
frrRibosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (186 aa)
proSProlyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (571 aa)
polCDNA polymerase III catalytic subunit, PolC type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1437 aa)
nusATranscription elongation factor; Participates in both transcription termination and antitermination. (362 aa)
infBBacterial translation initiation factor 2 (bIF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (918 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (613 aa)
PEPE_0918Peptidoglycan transpeptidase precursor, ErfK-YbiS-YhnG family. (477 aa)
PEPE_0930DNA replication protein DnaD. (234 aa)
pyrRPyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa)
PEPE_0945Fibronectin-binding protein. (568 aa)
PEPE_0972Ras superfamily GTP-binding protein YlqF; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (287 aa)
PEPE_1079SSU ribosomal protein S1P. (402 aa)
PEPE_1094DNA polymerase III catalytic subunit, DnaE type. (1107 aa)
sigARNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (379 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (620 aa)
glySglycyl-tRNA synthetase beta chain. (690 aa)
glyQglycyl-tRNA synthetase alpha chain. (299 aa)
Your Current Organism:
Pediococcus pentosaceus
NCBI taxonomy Id: 278197
Other names: P. pentosaceus ATCC 25745, Pediococcus pentosaceus ATCC 25745, Pediococcus pentosaceus str. ATCC 25745, Pediococcus pentosaceus strain ATCC 25745
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