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PEPE_0241 PEPE_0241 pyrB pyrB pyrC pyrC carA carA carB carB pyrD pyrD PEPE_0383 PEPE_0383 PEPE_0484 PEPE_0484 udk udk pyrH pyrH pyrR pyrR carA-2 carA-2 PEPE_0944 PEPE_0944 PEPE_1051 PEPE_1051 thyA thyA cmk cmk PEPE_1150 PEPE_1150 upp upp tdk tdk tmk tmk PEPE_1488 PEPE_1488 PEPE_1489 PEPE_1489 PEPE_1504 PEPE_1504 pyrG pyrG PEPE_1644 PEPE_1644 pyrF pyrF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PEPE_0241Dihydroorotase. (410 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (425 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (361 aa)
carBCarbamoyl-phosphate synthase large subunit. (1057 aa)
pyrDDihydroorotate oxidase B, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (304 aa)
PEPE_0383NUDIX family hydrolase; Belongs to the Nudix hydrolase family. (140 aa)
PEPE_0484Ribonucleoside-triphosphate reductase / ribonucleoside-triphosphate reductase class III catalytic subunit. (723 aa)
udkUridine kinase. (218 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
pyrRPyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa)
carA-2Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (359 aa)
PEPE_0944Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (818 aa)
PEPE_1051Nucleoside diphosphate kinase; Belongs to the NDK family. (141 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (316 aa)
cmkCytidylate kinase. (226 aa)
PEPE_1150Deoxycytidylate deaminase. (160 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tdkThymidine kinase. (197 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (209 aa)
PEPE_1488Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (721 aa)
PEPE_1489Ribonucleoside-diphosphate reductase class Ib beta subunit. (317 aa)
PEPE_1504Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (177 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa)
PEPE_1644Nucleoside diphosphate kinase; Belongs to the NDK family. (145 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (246 aa)
Your Current Organism:
Pediococcus pentosaceus
NCBI taxonomy Id: 278197
Other names: P. pentosaceus ATCC 25745, Pediococcus pentosaceus ATCC 25745, Pediococcus pentosaceus str. ATCC 25745, Pediococcus pentosaceus strain ATCC 25745
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