(23 nodes) Mixed, incl. RAF-independent MAPK1/3 activation, and Activation of the AP-1 family of transcription factors network (Danaus plexippus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KGM_206061	Putative slingshot dual specificity phosphatase. (985 aa)
	KGM_205498	Actin-depolymerizing factor 1; Belongs to the actin-binding proteins ADF family. (148 aa)
	KGM_203627	Atf2. (446 aa)
	KGM_200347	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily. (338 aa)
	KGM_215814	BZIP domain-containing protein. (303 aa)
	KGM_213743A	PPM-type phosphatase domain-containing protein. (295 aa)
	KGM_216188	Dual-specificity protein phosphatase. (236 aa)
	KGM_207552	Dual specificity protein phosphatase. (344 aa)
	KGM_202369	Uncharacterized protein. (627 aa)
	KGM_202887	Transcriptional activator of the JUN family. (80 aa)
	KGM_215329	Dual specificity protein phosphatase 12. (325 aa)
	KGM_203439	Uncharacterized protein. (1684 aa)
	KGM_215328A	Uncharacterized protein. (308 aa)
	KGM_200758	Mitogen-activated protein kinase. (490 aa)
	KGM_206613	Cyclic AMP-dependent transcription factor ATF-3. (392 aa)
	KGM_214573	Transcription factor kayak. (385 aa)
	KGM_213902	LAC protein. (577 aa)
	KGM_215664	Mitogen-activated protein kinase. (360 aa)
	KGM_213875	Mitogen-activated protein kinase kinase kinase 4. (1406 aa)
	KGM_216187	Tyrosine-protein phosphatase 99A. (1122 aa)
	KGM_206833	LIM domain kinase 1 isoform 2. (988 aa)
	KGM_215328B	Uncharacterized protein. (63 aa)
	KGM_212091A	Extracellular regulated MAP kinase. (43 aa)

Your Current Organism:

Danaus plexippus

NCBI taxonomy Id: 278856
Other names: D. plexippus plexippus, Danaus plexippus plexippus

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGM_200347	KGM_200758	A0A212EP69	A0A212F7P9	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.935
KGM_200347	KGM_202887	A0A212EP69	A0A212F3W3	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	Transcriptional activator of the JUN family.	0.442
KGM_200347	KGM_203627	A0A212EP69	A0A212EKW2	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	Atf2.	0.414
KGM_200347	KGM_206833	A0A212EP69	A0A212FMY9	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	LIM domain kinase 1 isoform 2.	0.413
KGM_200347	KGM_212091A	A0A212EP69	A0A212FQ07	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	Extracellular regulated MAP kinase.	0.952
KGM_200347	KGM_213875	A0A212EP69	A0A212FGP7	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 4.	0.961
KGM_200347	KGM_215664	A0A212EP69	A0A212FF41	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.998
KGM_200758	KGM_200347	A0A212F7P9	A0A212EP69	Mitogen-activated protein kinase.	Putative mitogen-activated protein kinase; Belongs to the protein kinase superfamily.	0.935
KGM_200758	KGM_202369	A0A212F7P9	A0A212F0X0	Mitogen-activated protein kinase.	Uncharacterized protein.	0.910
KGM_200758	KGM_202887	A0A212F7P9	A0A212F3W3	Mitogen-activated protein kinase.	Transcriptional activator of the JUN family.	0.687
KGM_200758	KGM_203439	A0A212F7P9	A0A212F5T0	Mitogen-activated protein kinase.	Uncharacterized protein.	0.894
KGM_200758	KGM_203627	A0A212F7P9	A0A212EKW2	Mitogen-activated protein kinase.	Atf2.	0.952
KGM_200758	KGM_206061	A0A212F7P9	A0A212EIG0	Mitogen-activated protein kinase.	Putative slingshot dual specificity phosphatase.	0.656
KGM_200758	KGM_206613	A0A212F7P9	A0A212F7U5	Mitogen-activated protein kinase.	Cyclic AMP-dependent transcription factor ATF-3.	0.756
KGM_200758	KGM_206833	A0A212F7P9	A0A212FMY9	Mitogen-activated protein kinase.	LIM domain kinase 1 isoform 2.	0.413
KGM_200758	KGM_207552	A0A212F7P9	A0A212F0I3	Mitogen-activated protein kinase.	Dual specificity protein phosphatase.	0.772
KGM_200758	KGM_213743A	A0A212F7P9	A0A212EZ68	Mitogen-activated protein kinase.	PPM-type phosphatase domain-containing protein.	0.570
KGM_200758	KGM_213875	A0A212F7P9	A0A212FGP7	Mitogen-activated protein kinase.	Mitogen-activated protein kinase kinase kinase 4.	0.611
KGM_200758	KGM_213902	A0A212F7P9	A0A212F994	Mitogen-activated protein kinase.	LAC protein.	0.625
KGM_200758	KGM_214573	A0A212F7P9	A0A212F930	Mitogen-activated protein kinase.	Transcription factor kayak.	0.816