(35 nodes) Regulation of ERK1 and ERK2 cascade network (Danaus plexippus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	KGM_210727	Ras protein. (184 aa)
	KGM_203250	Cytohesin-1. (545 aa)
	KGM_202429	Putative E3 ubiquitin-protein ligase CBL. (181 aa)
	KGM_213146B	Purity of essence. (1161 aa)
	KGM_213147	Purity of essence. (2269 aa)
	KGM_208778B	Vav isoform 1. (621 aa)
	KGM_206933	Chimerin. (452 aa)
	KGM_215992	Vascular endothelial growth factor receptor 2. (1286 aa)
	KGM_205518A	Leukocyte receptor tyrosine protein kinase. (957 aa)
	KGM_205344	DRK protein. (211 aa)
	KGM_203128	Argos. (265 aa)
	KGM_203127	Uncharacterized protein. (101 aa)
	KGM_201391	Rho GTPase-activating protein 1 isoform 2. (493 aa)
	KGM_203258	Dedicator of cytokinesis protein 3; Belongs to the DOCK family. (1710 aa)
	KGM_203439	Uncharacterized protein. (1684 aa)
	KGM_215325	Raf kinase effector of Ras. (849 aa)
	KGM_205518B	Leukocyte receptor tyrosine protein kinase. (1526 aa)
	KGM_203965	Tyrosine phosphatase. (457 aa)
	KGM_214302	Putative High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase; Belongs to the cyclic nucleotide phosphodiesterase family. (663 aa)
	KGM_214301	Phosphodiesterase 8 isoform A. (259 aa)
	KGM_215271	Putative Ankyrin repeat-containing protein. (68 aa)
	KGM_201559	Calcium and integrin binding protein CIB. (174 aa)
	KGM_212485	Ubiquitin-conjugating enzyme rad6; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	KGM_208777	Vav like protein. (838 aa)
	KGM_207160	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1190 aa)
	KGM_208560	E3 ubiquitin-protein ligase HECTD1. (2363 aa)
	KGM_203202	Ribosomal protein S6 kinase. (767 aa)
	KGM_214655	Serpin peptidase inhibitor clade F. (103 aa)
	KGM_212537B	Putative sprouty protein evh1 domain containing. (73 aa)
	KGM_205162	Putative sprouty. (79 aa)
	KGM_207552	Dual specificity protein phosphatase. (344 aa)
	KGM_206502	Uncharacterized protein. (1201 aa)
	KGM_212764	Signal transduction protein lnk-realted. (475 aa)
	KGM_210076	Uncharacterized protein. (208 aa)
	KGM_213146A	Purity of essence. (2099 aa)

Your Current Organism:

Danaus plexippus

NCBI taxonomy Id: 278856
Other names: D. plexippus plexippus, Danaus plexippus plexippus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGM_202429	KGM_205162	A0A212FER2	A0A212EY65	Putative E3 ubiquitin-protein ligase CBL.	Putative sprouty.	0.987
KGM_202429	KGM_205344	A0A212FER2	A0A212FIT9	Putative E3 ubiquitin-protein ligase CBL.	DRK protein.	0.991
KGM_202429	KGM_205518A	A0A212FER2	A0A212FJE7	Putative E3 ubiquitin-protein ligase CBL.	Leukocyte receptor tyrosine protein kinase.	0.939
KGM_202429	KGM_205518B	A0A212FER2	A0A212F8R6	Putative E3 ubiquitin-protein ligase CBL.	Leukocyte receptor tyrosine protein kinase.	0.939
KGM_202429	KGM_207160	A0A212FER2	A0A212EMM4	Putative E3 ubiquitin-protein ligase CBL.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.723
KGM_202429	KGM_208777	A0A212FER2	A0A212FB71	Putative E3 ubiquitin-protein ligase CBL.	Vav like protein.	0.767
KGM_202429	KGM_208778B	A0A212FER2	A0A212F8T1	Putative E3 ubiquitin-protein ligase CBL.	Vav isoform 1.	0.767
KGM_202429	KGM_212764	A0A212FER2	A0A212F280	Putative E3 ubiquitin-protein ligase CBL.	Signal transduction protein lnk-realted.	0.794
KGM_202429	KGM_215325	A0A212FER2	A0A212F6A7	Putative E3 ubiquitin-protein ligase CBL.	Raf kinase effector of Ras.	0.506
KGM_202429	KGM_215992	A0A212FER2	A0A212FLC7	Putative E3 ubiquitin-protein ligase CBL.	Vascular endothelial growth factor receptor 2.	0.634
KGM_203258	KGM_205344	A0A212F4P7	A0A212FIT9	Dedicator of cytokinesis protein 3; Belongs to the DOCK family.	DRK protein.	0.420
KGM_203439	KGM_205344	A0A212F5T0	A0A212FIT9	Uncharacterized protein.	DRK protein.	0.503
KGM_203965	KGM_205344	A0A212F9N2	A0A212FIT9	Tyrosine phosphatase.	DRK protein.	0.607
KGM_203965	KGM_210727	A0A212F9N2	A0A212FGI8	Tyrosine phosphatase.	Ras protein.	0.562
KGM_205162	KGM_202429	A0A212EY65	A0A212FER2	Putative sprouty.	Putative E3 ubiquitin-protein ligase CBL.	0.987
KGM_205162	KGM_205344	A0A212EY65	A0A212FIT9	Putative sprouty.	DRK protein.	0.942
KGM_205162	KGM_215325	A0A212EY65	A0A212F6A7	Putative sprouty.	Raf kinase effector of Ras.	0.809
KGM_205344	KGM_202429	A0A212FIT9	A0A212FER2	DRK protein.	Putative E3 ubiquitin-protein ligase CBL.	0.991
KGM_205344	KGM_203258	A0A212FIT9	A0A212F4P7	DRK protein.	Dedicator of cytokinesis protein 3; Belongs to the DOCK family.	0.420
KGM_205344	KGM_203439	A0A212FIT9	A0A212F5T0	DRK protein.	Uncharacterized protein.	0.503