(58 nodes) FoxO signaling pathway network (Danaus plexippus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KGM_211224	Putative AMP-activated protein kinase gamma regulatory subunit. (649 aa)
	KGM_212579	SNF4/AMP-activated protein kinase gamma subunit. (774 aa)
	KGM_206060	Polo kinase 4. (666 aa)
	KGM_210561	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (338 aa)
	KGM_210929	Cyclin 3; Belongs to the cyclin family. (486 aa)
	KGM_207162	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (448 aa)
	KGM_200042	Samia bombyxin protein A-3. (99 aa)
	KGM_201991	Phosphatidylinositol 3-kinase 60. (406 aa)
	KGM_201001	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (573 aa)
	KGM_202654	Uncharacterized protein. (2168 aa)
	KGM_202573	Mitochondrial phosphoenolpyruvate carboxykinase isoform 1. (641 aa)
	KGM_215820	Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. (2281 aa)
	KGM_202587	Catalase. (560 aa)
	KGM_202586	Catalase. (560 aa)
	KGM_215496	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
	KGM_207335	Mothers against decapentaplegic homolog. (727 aa)
	KGM_213169	Mitogen-activated protein kinase. (449 aa)
	KGM_206513	Uncharacterized protein. (157 aa)
	KGM_212192B	Cyclin D; Belongs to the cyclin family. (194 aa)
	KGM_203565	Non-specific serine/threonine protein kinase. (503 aa)
	KGM_212091B	Mitogen-activated protein kinase. (166 aa)
	KGM_212958	F-box domain-containing protein. (487 aa)
	KGM_214713	Arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (353 aa)
	KGM_206157	Insulin peptide; Belongs to the insulin family. (99 aa)
	KGM_200172	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (843 aa)
	KGM_200011B	Glucose-6-phosphatase. (309 aa)
	KGM_202851	Fork head domain transcription factor slp2. (242 aa)
	KGM_202854	Forkfead transcription factor G1. (303 aa)
	KGM_212769	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (468 aa)
	KGM_202681	Samia bombyxin protein A-3. (122 aa)
	KGM_209670	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (507 aa)
	KGM_215872	Serine/threonine kinase LKB1; Belongs to the protein kinase superfamily. (454 aa)
	KGM_207456	Cyclin D; Belongs to the cyclin family. (329 aa)
	KGM_210052	Catalase. (456 aa)
	KGM_210053	Catalase. (513 aa)
	KGM_203846	Cyclin B protein; Belongs to the cyclin family. (490 aa)
	KGM_203845	Cyclin B protein; Belongs to the cyclin family. (493 aa)
	KGM_203453	Putative ras GTP exchange factor son of sevenless. (1468 aa)
	KGM_215325	Raf kinase effector of Ras. (849 aa)
	KGM_205354	Putative ubiquitin specific protease 7; Belongs to the peptidase C19 family. (1236 aa)
	KGM_212327	Uncharacterized protein. (353 aa)
	KGM_205031	Cyclin g. (506 aa)
	KGM_212475	Mothers against decapentaplegic homolog. (453 aa)
	KGM_202564	IKKbeta. (528 aa)
	KGM_215072	Small G protein ras. (190 aa)
	KGM_211637	Autophagy-Related Protein Atg8 chain B. (117 aa)
	KGM_213441	Ubiquitin carboxyl-terminal hydrolase. (526 aa)
	KGM_211731	Putative homer. (371 aa)
	KGM_208863	Forkhead box sub-group O. (336 aa)
	KGM_215664	Mitogen-activated protein kinase. (360 aa)
	KGM_205800	AMP-activated protein kinase beta subunit. (280 aa)
	KGM_204858	3-phosphoinositide-dependent protein kinase 1. (573 aa)
	KGM_206256	MAP kinse-ERK kinase; Belongs to the protein kinase superfamily. (403 aa)
	KGM_209973	Putative Mdm2 transformed 3T3 cell double minute 2 p53 binding protein. (295 aa)
	KGM_205344	DRK protein. (211 aa)
	KGM_212179	Serine/threonine kinase NLK. (390 aa)
	KGM_201156	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (122 aa)
	KGM_206801	Receptor protein-tyrosine kinase. (1446 aa)

Your Current Organism:

Danaus plexippus

NCBI taxonomy Id: 278856
Other names: D. plexippus plexippus, Danaus plexippus plexippus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGM_200011B	KGM_202573	A0A212F1K5	A0A212ESQ8	Glucose-6-phosphatase.	Mitochondrial phosphoenolpyruvate carboxykinase isoform 1.	0.591
KGM_200011B	KGM_203565	A0A212F1K5	A0A212EWQ2	Glucose-6-phosphatase.	Non-specific serine/threonine protein kinase.	0.411
KGM_200011B	KGM_208863	A0A212F1K5	A0A212FE80	Glucose-6-phosphatase.	Forkhead box sub-group O.	0.435
KGM_200042	KGM_202681	A0A212EPD8	A0A212F2W7	Samia bombyxin protein A-3.	Samia bombyxin protein A-3.	0.900
KGM_200042	KGM_206157	A0A212EPD8	A0A212EZ83	Samia bombyxin protein A-3.	Insulin peptide; Belongs to the insulin family.	0.900
KGM_200172	KGM_201001	A0A212F0E0	A0A212EQA5	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	0.953
KGM_200172	KGM_201991	A0A212F0E0	A0A212EPK6	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol 3-kinase 60.	0.997
KGM_200172	KGM_203453	A0A212F0E0	A0A212F5U9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Putative ras GTP exchange factor son of sevenless.	0.719
KGM_200172	KGM_203565	A0A212F0E0	A0A212EWQ2	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Non-specific serine/threonine protein kinase.	0.827
KGM_200172	KGM_204858	A0A212F0E0	A0A212FGW0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	3-phosphoinositide-dependent protein kinase 1.	0.767
KGM_200172	KGM_205344	A0A212F0E0	A0A212FIT9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	DRK protein.	0.688
KGM_200172	KGM_206801	A0A212F0E0	A0A212FMG7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Receptor protein-tyrosine kinase.	0.749
KGM_200172	KGM_208863	A0A212F0E0	A0A212FE80	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Forkhead box sub-group O.	0.492
KGM_200172	KGM_215072	A0A212F0E0	A0A212FCP0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Small G protein ras.	0.955
KGM_200172	KGM_215325	A0A212F0E0	A0A212F6A7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Raf kinase effector of Ras.	0.470
KGM_201001	KGM_200172	A0A212EQA5	A0A212F0E0	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.953
KGM_201001	KGM_201991	A0A212EQA5	A0A212EPK6	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	Phosphatidylinositol 3-kinase 60.	0.945
KGM_201001	KGM_202564	A0A212EQA5	A0A212FC49	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	IKKbeta.	0.930
KGM_201001	KGM_203565	A0A212EQA5	A0A212EWQ2	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	Non-specific serine/threonine protein kinase.	0.838
KGM_201001	KGM_204858	A0A212EQA5	A0A212FGW0	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	3-phosphoinositide-dependent protein kinase 1.	0.469