STRINGSTRING
malS malS tdh tdh yvcT yvcT yvfV yvfV BL03435 BL03435 hisD hisD ycsA ycsA tuaD tuaD BL03089 BL03089 BL03077 BL03077 fabL fabL glvA glvA mtlD mtlD gpsA gpsA yueD yueD yugJ yugJ gbsB gbsB yulF yulF kduD kduD guaB guaB fabG fabG murB murB yusL yusL BL02138 BL02138 hom hom aroD aroD BL01969 BL01969 zwf zwf ribD ribD BL01803 BL01803 ldh ldh ycdF ycdF yqjI yqjI gdh gdh melA melA dxr dxr ymfI ymfI BL01177 BL01177 mleA mleA yvaA yvaA uxaB uxaB yvgN yvgN serA serA leuB leuB ilvC ilvC ytkK ytkK ytsJ ytsJ icd icd mdh mdh acuA acuA araM araM BL00282 BL00282 BL00250 BL00250 idh idh BL00199 BL00199 gntZ gntZ BL00169 BL00169 yjmF yjmF licH licH mmgB mmgB maeA maeA dhbA dhbA panE panE adhA adhA BL03800 BL03800
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
malSMalate dehydrogenase (decarboxylating). (565 aa)
tdhThreonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (346 aa)
yvcTProbable 2-ketogluconate reductase YvcT; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
yvfVYvfV; Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. (238 aa)
BL03435D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain. (316 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa)
ycsAIsocitrate/isopropylmalate dehydrogenase. (352 aa)
tuaDUDP-glucose 6-dehydrogenase TuaD. (443 aa)
BL03089Putative iron-binding oxidoreductase. (367 aa)
BL03077UDP-glucose 6-dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (431 aa)
fabLEnoyl-acyl carrier protein reductase. (250 aa)
glvAGlycoside Hydrolase,Family 4, GlvA; 6-phospho-alpha-glucosidase. (449 aa)
mtlDMannitol-1-phosphate dehydrogenase. (379 aa)
gpsANAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (346 aa)
yueDShort-chain dehydrogenase/reductase SDR. (243 aa)
yugJIron-containing alcohol dehydrogenase YugJ. (387 aa)
gbsBAlcohol dehydrogenase. (402 aa)
yulFPutative oxidoreductase. (328 aa)
kduD2-keto-3-deoxygluconate oxidoreductase. (254 aa)
guaBInosine-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
fabGBeta-ketoacyl-acyl carrier protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (303 aa)
yusL3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase YusL. (796 aa)
BL02138D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain,D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain. (320 aa)
homHomoserine dehydrogenase. (433 aa)
aroDShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (278 aa)
BL01969Short-chain dehydrogenase/reductase SDR,Calcium-binding EF-hand; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (238 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (492 aa)
ribDRiboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (362 aa)
BL01803Glycoside Hydrolase Family 4. (444 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (319 aa)
ycdFGlucose 1-dehydrogenase II. (257 aa)
yqjI6-phosphogluconate dehydrogenase, decarboxylating YqjI; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (469 aa)
gdhGlucose 1-dehydrogenase. (261 aa)
melAalpha-D-galactoside galactohydrolase, Glycoside Hydrolase Family 4,MelA. (432 aa)
dxr1-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (383 aa)
ymfIPutative oxidoreductase. (243 aa)
BL01177Beta-ketoacyl-acyl carrier protein reductase. (260 aa)
mleAMalolactic enzyme. (443 aa)
yvaAPutative oxidoreductase. (349 aa)
uxaBTagaturonate reductase (altronate oxidoreductase). (489 aa)
yvgNPutative 2,5-diketo-D-gluconic acid reductase YvgN. (279 aa)
serAPhosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (525 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (370 aa)
ilvCKetol-acid reductoisomerase (acetohydroxy-acid isomeroreductase); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa)
ytkKShort-chain dehydrogenase/reductase YtkK. (253 aa)
ytsJMalate dehydrogenase isozyme YtsJ. (411 aa)
icdIsocitrate dehydrogenase. (423 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
acuAAcetoin dehydrogenase; Part of the acuABC operon, which is possibly involved in the breakdown of acetoin and butanediol. Acts as an acetyltransferase inactivating acetyl-CoA synthetase AcsA via acetylation at a Lys residue. (210 aa)
araMAraM; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species. Belongs to the glycerol-1-phosphate dehydrogenase family. (401 aa)
BL00282Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (283 aa)
BL00250Putative Glycerol dehydrogenase. (349 aa)
idhMyo-inositol 2-dehydrogenase; Involved in the oxidation of myo-inositol (MI) and D-chiro- inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D- chiro-inositol (1KDCI), respectively. (344 aa)
BL00199Alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (867 aa)
gntZ6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (467 aa)
BL00169Putative Iron-containing alcohol dehydrogenase. (351 aa)
yjmFShort-chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (282 aa)
licHGlycoside Hydrolase Family 4. (442 aa)
mmgB3-hydroxybutyryl-CoA dehydrogenase. (287 aa)
maeAMalate dehyrogenase isozyme. (567 aa)
dhbA2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (256 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (293 aa)
adhANADP-dependent alcohol dehydrogenase. (352 aa)
BL03800Putative Zn binding dehydrogenase. (337 aa)
Your Current Organism:
Bacillus licheniformis
NCBI taxonomy Id: 279010
Other names: B. licheniformis DSM 13 = ATCC 14580, Bacillus licheniformis ATCC 14580, Bacillus licheniformis ATCC 14580 = DSM 13, Bacillus licheniformis DSM 13, Bacillus licheniformis DSM 13 = ATCC 14580
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