STRINGSTRING
ytwF ytwF malS malS ydaP ydaP BL00199 BL00199 mdh mdh ytzA ytzA pyk pyk accA accA accD accD ytsJ ytsJ ackA ackA acsA acsA ytbE ytbE ytcI ytcI dhaS dhaS leuA leuA yvgN yvgN citG citG yqjP yqjP pckA pckA mleA mleA BL01065 BL01065 BL01194 BL01194 bfmBC bfmBC accC accC accB accB yqgX yqgX pdhA pdhA pdhB pdhB pdhC pdhC pdhD pdhD ldh ldh BL01863 BL01863 yyaH yyaH yngH yngH BL01989 BL01989 BL01993 BL01993 pps pps yrkF yrkF yrkH yrkH BL02060 BL02060 BL02410 BL02410 BL02644 BL02644 endoAI endoAI pycA pycA acoC acoC acoL acoL yflN yflN BL03097 BL03097 yflL yflL BL03128 BL03128 BL03133 BL03133 yvcT yvcT pta pta mmgA mmgA ywbC ywbC ywdH ywdH maeA maeA BL05212 BL05212
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ytwFConserved protein YtwF. (104 aa)
malSMalate dehydrogenase (decarboxylating). (565 aa)
ydaPPyruvate decarboxylase; Belongs to the TPP enzyme family. (573 aa)
BL00199Alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (867 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
ytzAConserved membrane protein YtzA. (128 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
accAAcetyl CoA carboxylase (alpha subunit); Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
accDacetyl-CoA carboxylase (beta subunit); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa)
ytsJMalate dehydrogenase isozyme YtsJ. (411 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
acsAacetyl-CoA synthetase. (572 aa)
ytbEAldo/keto reductase YtbE. (282 aa)
ytcIAMP-dependent synthetase and ligase YtcI. (529 aa)
dhaSAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (495 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (518 aa)
yvgNPutative 2,5-diketo-D-gluconic acid reductase YvgN. (279 aa)
citGFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
yqjPConserved protein YqjP. (317 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (527 aa)
mleAMalolactic enzyme. (443 aa)
BL01065Phosphoenolpyruvate synthase; BL01065 similar to pps from Bacillus subtilis. (873 aa)
BL01194Conserved hypothetical protein; Molecular Function: cysteine-type endopeptidase activity, Biological Process: proteolysis and peptidolysis. (141 aa)
bfmBCBranched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase). (473 aa)
accCacetyl-CoA carboxylase subunit (biotin carboxylase subunit); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
accBacetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa)
yqgXConserved protein YqgX. (212 aa)
pdhAPyruvate dehydrogenase (E1 alpha subunit); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa)
pdhBPyruvate dehydrogenase (E1 beta subunit). (325 aa)
pdhCPyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit). (430 aa)
pdhDDihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. (470 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (319 aa)
BL01863Putative formate C-acetyltransferase. (741 aa)
yyaHPutative Glyoxalase family protein. (125 aa)
yngHCarbamoyl-phosphate synthase L chain, ATP binding. (446 aa)
BL01989Pyruvate carboxylase. (70 aa)
BL01993acetyl-CoA synthetase. (650 aa)
ppsPhosphoenolpyruvate synthase. (864 aa)
yrkFYrkF; Belongs to the sulfur carrier protein TusA family. (190 aa)
yrkHConserved protein YrkH. (376 aa)
BL02060Metallo-beta-lactamase/rhodanese-like domain protein. (477 aa)
BL02410Hypothetical protein; May be related to nikS, involved in the assembly of antibiotic nikkomycin. (405 aa)
BL02644Malate synthase A; Belongs to the malate synthase family. (529 aa)
endoAITranscriptional inhibitor endoAI. (93 aa)
pycAPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
acoCAcetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (377 aa)
acoLAcetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). (458 aa)
yflNBeta-lactamase-like protein YflN. (264 aa)
BL03097Beta-lactamase-like protein. (260 aa)
yflLAcylphosphatase YflL. (90 aa)
BL03128Putative Metallo-beta-lactamase family protein. (274 aa)
BL03133Beta-lactamase-like protein. (237 aa)
yvcTProbable 2-ketogluconate reductase YvcT; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
ptaPhosphotransacetylase. (323 aa)
mmgAacetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
ywbCPutative lyase YwbC. (126 aa)
ywdHAldehyde dehydrogenase,Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (460 aa)
maeAMalate dehyrogenase isozyme. (567 aa)
BL05212Phosphoenolpyruvate synthase. (888 aa)
Your Current Organism:
Bacillus licheniformis
NCBI taxonomy Id: 279010
Other names: B. licheniformis DSM 13 = ATCC 14580, Bacillus licheniformis ATCC 14580, Bacillus licheniformis ATCC 14580 = DSM 13, Bacillus licheniformis DSM 13, Bacillus licheniformis DSM 13 = ATCC 14580
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.