STRINGSTRING
LT85_0184 LT85_0184 LT85_0191 LT85_0191 LT85_0227 LT85_0227 LT85_0354 LT85_0354 LT85_0559 LT85_0559 LT85_0560 LT85_0560 LT85_0647 LT85_0647 LT85_0814 LT85_0814 LT85_0940 LT85_0940 LT85_1229 LT85_1229 LT85_1431 LT85_1431 LT85_1434 LT85_1434 LT85_1489 LT85_1489 LT85_1716 LT85_1716 LT85_2161 LT85_2161 LT85_2171 LT85_2171 leuC leuC leuD leuD LT85_2478 LT85_2478 LT85_2541 LT85_2541 LT85_2548 LT85_2548 LT85_2633 LT85_2633 leuB leuB leuD-2 leuD-2 leuC-2 leuC-2 LT85_2893 LT85_2893 LT85_2894 LT85_2894 LT85_2895 LT85_2895 LT85_2898 LT85_2898 LT85_2899 LT85_2899 LT85_2900 LT85_2900 LT85_2901 LT85_2901 mdh mdh LT85_2906 LT85_2906 ilvD ilvD LT85_3105 LT85_3105 LT85_3106 LT85_3106 LT85_3190 LT85_3190 leuA leuA LT85_3413 LT85_3413 LT85_3414 LT85_3414 LT85_3455 LT85_3455 leuA-2 leuA-2 ilvC ilvC LT85_3506 LT85_3506 LT85_3507 LT85_3507 LT85_3585 LT85_3585 fumC fumC LT85_3866 LT85_3866 murI murI LT85_3920 LT85_3920 LT85_3978 LT85_3978 LT85_4069 LT85_4069 LT85_4071 LT85_4071 LT85_4072 LT85_4072 LT85_4332 LT85_4332 ilvE ilvE sucD sucD sucC sucC LT85_4535 LT85_4535 LT85_4571 LT85_4571 LT85_4935 LT85_4935 LT85_4940 LT85_4940
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LT85_0184Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (343 aa)
LT85_0191GCN5-related N-acetyltransferase. (250 aa)
LT85_0227Ketoglutarate semialdehyde dehydrogenase. (525 aa)
LT85_0354Branched-chain amino acid aminotransferase. (317 aa)
LT85_0559Glutamate synthase [NADPH] large chain. (1562 aa)
LT85_0560Glutamate synthase [NADPH] small chain. (487 aa)
LT85_0647Ketoglutarate semialdehyde dehydrogenase. (524 aa)
LT85_0814D-Lactate dehydrogenase; Cytochrome c-dependent. (469 aa)
LT85_0940NADP-dependent malic enzyme; Belongs to the malic enzymes family. (767 aa)
LT85_1229Isocitrate dehydrogenase [NADP]. (417 aa)
LT85_1431Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (483 aa)
LT85_1434Aldehyde dehydrogenase A. (474 aa)
LT85_1489NADP-dependent malic enzyme. (769 aa)
LT85_1716Isocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (744 aa)
LT85_2161Aspartate aminotransferase. (409 aa)
LT85_2171L-lactate dehydrogenase. (376 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (213 aa)
LT85_2478PF00070 family. (460 aa)
LT85_2541Hypothetical protein. (294 aa)
LT85_2548Putative membrane protein. (446 aa)
LT85_2633NAD-specific glutamate dehydrogenase. (1620 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa)
leuD-23-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (215 aa)
leuC-23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
LT85_2893Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. (475 aa)
LT85_2894Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (421 aa)
LT85_28952-oxoglutarate dehydrogenase E1 component. (951 aa)
LT85_2898Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (237 aa)
LT85_2899Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
LT85_2900Succinate dehydrogenase hydrophobic membrane anchor protein. (121 aa)
LT85_2901Succinate dehydrogenase cytochrome b-556 subunit. (136 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
LT85_2906Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (624 aa)
LT85_3105Hypothetical protein. (243 aa)
LT85_3106Hypothetical protein. (273 aa)
LT85_3190Glu/Leu/Phe/Val dehydrogenase family protein. (420 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (567 aa)
LT85_3413Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (802 aa)
LT85_3414Hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (282 aa)
LT85_3455Ketoglutarate semialdehyde dehydrogenase. (524 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (540 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
LT85_3506Acetolactate synthase small subunit. (163 aa)
LT85_3507Acetolactate synthase large subunit. (575 aa)
LT85_3585Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (893 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
LT85_3866Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (518 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (288 aa)
LT85_3920Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (537 aa)
LT85_3978Pyruvate kinase; Belongs to the pyruvate kinase family. (473 aa)
LT85_4069Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (699 aa)
LT85_4071Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (442 aa)
LT85_4072Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa)
LT85_4332Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
sucDSuccinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
sucCSuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
LT85_4535NAD-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (428 aa)
LT85_4571Indolepyruvate ferredoxin oxidoreductase; Alpha and beta subunits. (1207 aa)
LT85_4935Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (484 aa)
LT85_4940Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa)
Your Current Organism:
Collimonas arenae
NCBI taxonomy Id: 279058
Other names: C. arenae, CCUG 54727, Collimonas arenae Hoppener-Ogawa et al. 2008, Collimonas group A, Collimonas sp. CTO 282, Collimonas sp. NCCB 100025, Collimonas sp. NCCB 100026, Collimonas sp. NCCB 100031, Collimonas sp. Ter10, Collimonas sp. Ter146, Collimonas sp. Ter252, Collimonas sp. Ter282, LMG 23964, LMG:23964, NCCB 100031, strain Ter10
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