STRINGSTRING
Saro_0073 Saro_0073 hemE hemE Saro_0119 Saro_0119 Saro_0248 Saro_0248 Saro_0322 Saro_0322 cobQ cobQ cobD cobD Saro_0325 Saro_0325 cobS cobS Saro_0327 Saro_0327 cobT cobT Saro_0329 Saro_0329 Saro_0330 Saro_0330 Saro_0331 Saro_0331 Saro_0332 Saro_0332 cbiA cbiA Saro_0334 Saro_0334 Saro_0335 Saro_0335 Saro_0336 Saro_0336 Saro_0337 Saro_0337 Saro_0338 Saro_0338 Saro_0339 Saro_0339 Saro_0340 Saro_0340 Saro_0341 Saro_0341 Saro_0342 Saro_0342 Saro_0343 Saro_0343 Saro_0553 Saro_0553 Saro_1497 Saro_1497 Saro_1498 Saro_1498 Saro_1797 Saro_1797 Saro_2389 Saro_2389 Saro_2443 Saro_2443 Saro_2536 Saro_2536 Saro_2556 Saro_2556 Saro_2557 Saro_2557 Saro_2558 Saro_2558 Saro_2559 Saro_2559 Saro_2560 Saro_2560 Saro_2561 Saro_2561 Saro_2562 Saro_2562 Saro_2563 Saro_2563 Saro_2564 Saro_2564 Saro_2565 Saro_2565 Saro_2566 Saro_2566 Saro_2569 Saro_2569 Saro_2674 Saro_2674 Saro_2786 Saro_2786 Saro_2787 Saro_2787 Saro_2891 Saro_2891 Saro_2965 Saro_2965 Saro_3087 Saro_3087 Saro_3249 Saro_3249 Saro_3250 Saro_3250 Saro_3251 Saro_3251 cysD cysD cysN cysN Saro_3254 Saro_3254 hemH hemH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Saro_0073Porphobilinogen synthase; Belongs to the ALAD family. (330 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (341 aa)
Saro_0119Conserved hypothetical protein 701. (141 aa)
Saro_0248Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
Saro_0322Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa)
cobQAdenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (491 aa)
cobDAdenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (316 aa)
Saro_0325Aminotransferase. (327 aa)
cobSCobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (246 aa)
Saro_0327Phosphoglycerate/bisphosphoglycerate mutase. (189 aa)
cobTNicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (338 aa)
Saro_0329Protein of unknown function DUF1636. (135 aa)
Saro_0330cob(II)yrinic acid a,c-diamide reductase. (199 aa)
Saro_0331cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (208 aa)
Saro_0332precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. (254 aa)
cbiACobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (444 aa)
Saro_0334Precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. (261 aa)
Saro_0335Precorrin methylase. (126 aa)
Saro_0336precorrin-6Y C5,15-methyltransferase (decarboxylating). (399 aa)
Saro_0337precorrin-6A reductase. (253 aa)
Saro_0338Precorrin-3 methyltransferase. (262 aa)
Saro_0339Precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (245 aa)
Saro_0340precorrin-8X methylmutase. (209 aa)
Saro_0341Precorrin-3B synthase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (381 aa)
Saro_0342Cobaltochelatase CobN subunit. (1094 aa)
Saro_0343Cobalamin biosynthesis CobW. (350 aa)
Saro_0553ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (186 aa)
Saro_1497Hypothetical protein. (276 aa)
Saro_1498Di- and tricarboxylate transporters-like protein. (444 aa)
Saro_17975-aminolevulinate synthase. (406 aa)
Saro_2389Cobaltochelatase CobT subunit. (604 aa)
Saro_2443Alkanesulfonate monooxygenase. (362 aa)
Saro_2536Coproporphyrinogen oxidase. (287 aa)
Saro_2556uroporphyrinogen-III C-methyltransferase. (256 aa)
Saro_2557Conserved hypothetical protein. (98 aa)
Saro_2558Nitrite and sulphite reductase 4Fe-4S region. (544 aa)
Saro_2559Uncharacterized conserved protein UCP030820. (143 aa)
Saro_2560Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (270 aa)
Saro_2561Anion transporter. (466 aa)
Saro_2562Hypothetical protein. (223 aa)
Saro_2563Hypothetical protein. (250 aa)
Saro_2564TPR repeat protein. (450 aa)
Saro_2565Putative transmembrane protein. (392 aa)
Saro_2566TrkA-N. (366 aa)
Saro_2569Oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (449 aa)
Saro_2674Siroheme synthase. (261 aa)
Saro_2786Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (312 aa)
Saro_2787uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (226 aa)
Saro_2891Cobaltochelatase CobS subunit. (326 aa)
Saro_2965uroporphyrinogen-III C-methyltransferase. (259 aa)
Saro_3087Taurine catabolism dioxygenase TauD/TfdA. (304 aa)
Saro_3249OstA-like protein. (184 aa)
Saro_3250Conserved hypothetical protein. (214 aa)
Saro_32513'-5' exonuclease. (205 aa)
cysDSulfate adenylyltransferase subunit 2. (304 aa)
cysNAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (644 aa)
Saro_3254Hypothetical protein. (93 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (337 aa)
Your Current Organism:
Novosphingobium aromaticivorans
NCBI taxonomy Id: 279238
Other names: N. aromaticivorans DSM 12444, Novosphingobium aromaticivorans DSM 12444, Novosphingobium aromaticivorans str. DSM 12444, Novosphingobium aromaticivorans strain DSM 12444
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.