STRINGSTRING
groS groS groL groL Saro_0049 Saro_0049 Saro_0066 Saro_0066 ftsH ftsH Saro_0266 Saro_0266 Saro_0267 Saro_0267 Saro_0483 Saro_0483 clpS clpS aat aat Saro_0837 Saro_0837 lon lon Saro_1613 Saro_1613 Saro_1717 Saro_1717 Saro_1718 Saro_1718 Saro_1996 Saro_1996 dnaJ dnaJ dnaK dnaK grpE grpE hrcA hrcA Saro_2251 Saro_2251 Saro_2343 Saro_2343 Saro_2398 Saro_2398 Saro_2634 Saro_2634 hslV hslV Saro_2646 Saro_2646 clpB clpB clpX clpX clpP clpP Saro_3135 Saro_3135 Saro_3314 Saro_3314 Saro_3331 Saro_3331 Saro_3332 Saro_3332 Saro_3333 Saro_3333 Saro_3334 Saro_3334
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (547 aa)
Saro_0049Heat shock protein DnaJ-like protein. (325 aa)
Saro_0066ATP dependent Clp protease; Belongs to the ClpA/ClpB family. (792 aa)
ftsHMembrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (644 aa)
Saro_0266Thioredoxin. (301 aa)
Saro_0267Peptidase S16, lon-like protein. (209 aa)
Saro_0483Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (204 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (126 aa)
aatLeucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. (263 aa)
Saro_0837Peptidyl-prolyl cis-trans isomerase, cyclophilin type. (232 aa)
lonATP-dependent proteinase, Serine peptidase, MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (803 aa)
Saro_1613FAD-dependent pyridine nucleotide-disulfide oxidoreductase. (313 aa)
Saro_1717Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
Saro_1718Pyridine nucleotide-disulfide oxidoreductase, class-II, active site. (519 aa)
Saro_1996Thioredoxin; Belongs to the thioredoxin family. (106 aa)
dnaJChaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] (378 aa)
dnaKChaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (635 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (186 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (354 aa)
Saro_2251Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (232 aa)
Saro_2343Thioredoxin reductase. (322 aa)
Saro_2398Peptidase S1 and S6, chymotrypsin/Hap. (531 aa)
Saro_2634Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. (433 aa)
hslVHslV component of HslUV peptidase, Threonine peptidase, MEROPS family T01B; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (185 aa)
Saro_2646Ferritin and Dps; Belongs to the Dps family. (151 aa)
clpBAAA ATPase, central region; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (859 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (418 aa)
clpPATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (235 aa)
Saro_3135Superoxide dismutase, copper/zinc binding protein. (191 aa)
Saro_3314Heat shock protein Hsp70. (568 aa)
Saro_3331Peptidase S1C, Do; Belongs to the peptidase S1C family. (510 aa)
Saro_3332Protease FtsH subunit HflC; HflC and HflK could regulate a protease. (283 aa)
Saro_3333Protease FtsH subunit HflK; HflC and HflK could encode or regulate a protease. (374 aa)
Saro_3334ATPase; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (321 aa)
Your Current Organism:
Novosphingobium aromaticivorans
NCBI taxonomy Id: 279238
Other names: N. aromaticivorans DSM 12444, Novosphingobium aromaticivorans DSM 12444, Novosphingobium aromaticivorans str. DSM 12444, Novosphingobium aromaticivorans strain DSM 12444
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