STRINGSTRING
Saro_0188 Saro_0188 Saro_0432 Saro_0432 Saro_0614 Saro_0614 Saro_0674 Saro_0674 Saro_0809 Saro_0809 Saro_0816 Saro_0816 Saro_0867 Saro_0867 glcB glcB Saro_1050 Saro_1050 Saro_1069 Saro_1069 Saro_1104 Saro_1104 Saro_1178 Saro_1178 mdh mdh Saro_1197 Saro_1197 Saro_1222 Saro_1222 accD accD gloB gloB fumC fumC Saro_1757 Saro_1757 Saro_1758 Saro_1758 Saro_1859 Saro_1859 Saro_1860 Saro_1860 Saro_1861 Saro_1861 accA accA pdhA pdhA Saro_1909 Saro_1909 Saro_1945 Saro_1945 Saro_1946 Saro_1946 Saro_2078 Saro_2078 Saro_2079 Saro_2079 Saro_2110 Saro_2110 leuA leuA Saro_2306 Saro_2306 Saro_2349 Saro_2349 Saro_2370 Saro_2370 Saro_2502 Saro_2502 Saro_2567 Saro_2567 Saro_2599 Saro_2599 acsA acsA Saro_2801 Saro_2801 pckA pckA Saro_2938 Saro_2938 Saro_2948 Saro_2948 Saro_3037 Saro_3037 Saro_3291 Saro_3291
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Saro_0188Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
Saro_0432Pyruvate kinase; Belongs to the pyruvate kinase family. (484 aa)
Saro_0614Beta-lactamase-like protein. (314 aa)
Saro_0674CoA-binding protein. (705 aa)
Saro_0809Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
Saro_0816D-lactate dehydrogenase (cytochrome). (477 aa)
Saro_0867Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (714 aa)
Saro_1050FMN-dependent alpha-hydroxy acid dehydrogenase. (381 aa)
Saro_1069Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
Saro_1104Aldehyde dehydrogenase. (474 aa)
Saro_1178Dihydrolipoamide dehydrogenase. (466 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
Saro_1197Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (448 aa)
Saro_1222Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
accDacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
gloBHydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (254 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
Saro_1757Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (634 aa)
Saro_1758Thiamine pyrophosphate enzyme-like TPP-binding protein. (346 aa)
Saro_1859Pyruvate carboxyltransferase. (490 aa)
Saro_1860Carbamoyl-phosphate synthase L chain, ATP-binding protein. (444 aa)
Saro_1861Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (147 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
pdhAPyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (381 aa)
Saro_1909Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (461 aa)
Saro_1945Dihydrolipoamide dehydrogenase. (470 aa)
Saro_1946Dihydrolipoamide acetyltransferase, long form; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (427 aa)
Saro_2078Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
Saro_2079acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
Saro_2110Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (887 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa)
Saro_2306Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
Saro_2349Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (415 aa)
Saro_2370Beta-lactamase-like protein. (245 aa)
Saro_2502Conserved hypothetical protein. (510 aa)
Saro_2567Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (927 aa)
Saro_2599Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (472 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
Saro_2801Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (534 aa)
Saro_2938Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
Saro_2948D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein. (309 aa)
Saro_3037Glyoxalase/bleomycin resistance protein/dioxygenase. (145 aa)
Saro_3291Allosteric NADP-dependent malic enzyme. (754 aa)
Your Current Organism:
Novosphingobium aromaticivorans
NCBI taxonomy Id: 279238
Other names: N. aromaticivorans DSM 12444, Novosphingobium aromaticivorans DSM 12444, Novosphingobium aromaticivorans str. DSM 12444, Novosphingobium aromaticivorans strain DSM 12444
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