STRINGSTRING
APT85781.1 APT85781.1 APT85782.1 APT85782.1 hisC hisC APT85923.1 APT85923.1 gluQ gluQ APT85940.1 APT85940.1 lysC lysC asd asd proC proC APT86044.1 APT86044.1 guaB guaB APT86185.1 APT86185.1 guaA guaA folD folD metXA metXA APT86209.1 APT86209.1 upp upp APT86246.1 APT86246.1 purK purK purE purE dsdA dsdA aroA aroA APT86380.1 APT86380.1 APT86403.1 APT86403.1 serC serC APT86428.1 APT86428.1 thyA thyA purN purN purH purH APT86518.1 APT86518.1 glyA glyA APT86566.1 APT86566.1 dapD dapD APT86571.1 APT86571.1 folP folP putP putP lysA lysA APT86613.1 APT86613.1 thrB thrB gltX gltX fhs fhs hisG hisG hisE hisE pyrD pyrD whiA whiA yvcK yvcK rapZ rapZ ribH ribH ribBA ribBA APT86911.1 APT86911.1 ribD ribD fmt fmt def def priA priA metK metK gmk gmk pyrF pyrF carB carB carA carA pyrC pyrC pyrB pyrB pyrR pyrR APT86929.1 APT86929.1 APT86930.1 APT86930.1 APT86933.1 APT86933.1 aroQ aroQ aroB aroB aroK aroK aroC aroC APT86938.1 APT86938.1 APT86949.1 APT86949.1 apt apt APT86971.1 APT86971.1 APT86982.1 APT86982.1 dapF dapF dapA dapA thyX thyX dapB dapB pyrH pyrH APT87133.1 APT87133.1 APT87139.1 APT87139.1 hisI hisI hisF hisF APT87143.1 APT87143.1 priA-2 priA-2 hisH hisH APT87146.1 APT87146.1 APT87147.1 APT87147.1 hisB hisB hisC-2 hisC-2 hisD hisD APT87151.1 APT87151.1 ilvA ilvA APT87163.1 APT87163.1 gcvP gcvP gcvT gcvT gcvH gcvH glnA glnA glnA-2 glnA-2 gltB gltB gltD gltD APT87244.1 APT87244.1 APT87250.1 APT87250.1 APT87319.1 APT87319.1 proA proA APT87351.1 APT87351.1 APT87352.1 APT87352.1 APT87353.1 APT87353.1 proB proB APT87363.1 APT87363.1 APT87421.1 APT87421.1 preA preA APT87423.1 APT87423.1 APT87424.1 APT87424.1 APT87425.1 APT87425.1 hydA hydA APT87440.1 APT87440.1 serB serB APT87521.1 APT87521.1 cysK cysK cysE cysE purM purM purF purF purQ purQ purS purS purC purC APT87593.1 APT87593.1 purD purD APT87640.1 APT87640.1 APT87644.1 APT87644.1 APT87645.1 APT87645.1 APT87646.1 APT87646.1 APT87647.1 APT87647.1 folK folK folB folB folP-2 folP-2 folE folE hpt hpt tilS tilS APT87656.1 APT87656.1 APT87657.1 APT87657.1 purA purA pyrE pyrE APT87702.1 APT87702.1 APT87710.1 APT87710.1 APT87720.1 APT87720.1 pheA pheA APT87852.1 APT87852.1 APT87926.1 APT87926.1 APT87927.1 APT87927.1 trpD trpD trpB trpB trpA trpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
protein homology
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APT85781.1Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (313 aa)
APT85782.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (758 aa)
hisCAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (352 aa)
APT85923.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
gluQglutamyl-tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (306 aa)
APT85940.1N-carbamoyl-L-amino acid amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
lysCAspartate kinase; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family. (421 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (263 aa)
APT86044.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (506 aa)
APT86185.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (522 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
metXAHomoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (355 aa)
APT86209.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
APT86246.1Thiosulfate sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (376 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa)
dsdAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (430 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa)
APT86380.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
APT86403.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (376 aa)
APT86428.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. (176 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (265 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (206 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
APT86518.1Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
APT86566.1N-succinyldiaminopimelate aminotransferase; Catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (323 aa)
APT86571.1Succinyl-diaminopimelate desuccinylase; Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
folPDihydropteroate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
putPProline:sodium symporter PutP; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (520 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (446 aa)
APT86613.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (496 aa)
fhsFormate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. (554 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (371 aa)
whiASporulation protein; Involved in cell division and chromosome segregation. (330 aa)
yvcKHypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (338 aa)
rapZglmZ(sRNA)-inactivating NTPase; Displays ATPase and GTPase activities. (290 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (159 aa)
ribBA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (421 aa)
APT86911.1Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
ribD5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (344 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (322 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (169 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (679 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (410 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (189 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (287 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1111 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (382 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (456 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (194 aa)
APT86929.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
APT86930.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
APT86933.1X-Pro dipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (357 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (403 aa)
APT86938.1Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the shikimate dehydrogenase family. (277 aa)
APT86949.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (469 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)
APT86971.1Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
APT86982.1Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily. (295 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (281 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (304 aa)
thyXThymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (248 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (248 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa)
APT87133.1Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa)
APT87139.1Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (127 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
APT87143.1Inositol-phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
priA-2Phosphoribosyl isomerase; Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa)
APT87146.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
APT87147.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (55 aa)
hisBImidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
hisC-2Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa)
APT87151.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (427 aa)
APT87163.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
gcvPGlycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvP family. (949 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (370 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
glnAGlutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
glnA-2Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
gltBGlutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1526 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
APT87244.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
APT87250.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (445 aa)
APT87319.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (423 aa)
APT87351.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
APT87352.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
APT87353.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (410 aa)
APT87363.1Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
APT87421.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
preADihydropyrimidine dehydrogenase; NADH-dependent; catalyzes the conversion of pyrimidines to 5,6-dihydro compounds in pyrimidine degradation; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
APT87423.1Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
APT87424.1Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
APT87425.1N-carbamoyl-L-amino acid amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
hydAPhenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
APT87440.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
serBPhosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
APT87521.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
cysKCysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
cysESerine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (496 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (226 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (81 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (294 aa)
APT87593.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (428 aa)
APT87640.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
APT87644.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (308 aa)
APT87645.1Pantoate--beta-alanine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pantothenate synthetase family. (260 aa)
APT87646.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
APT87647.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa)
folP-2Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (296 aa)
folEGTP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
hptHypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (195 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (313 aa)
APT87656.1Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (98 aa)
APT87657.1MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (189 aa)
APT87702.1Sulfultransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
APT87710.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
APT87720.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (1144 aa)
pheAPrephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
APT87852.1Inositol-3-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
APT87926.1Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (516 aa)
APT87927.1Anthranilate synthase component II; TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (404 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (291 aa)
Your Current Organism:
Corynebacterium flavescens
NCBI taxonomy Id: 28028
Other names: ATCC 10340, C. flavescens, CCUG 28791, CIP 69.5, DSM 20296, IFO 14136, LMG 4046, LMG:4046, Microbacterium flavum , Mycobacterium flavum, NBRC 14136, NCCB 42012, NCIB 8707, NCIB:8707, NCIMB 8707
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