STRINGSTRING
APT85887.1 APT85887.1 betA betA lysC lysC asd asd lpdA lpdA gpmA gpmA APT86189.1 APT86189.1 solA solA dsdA dsdA serC serC glyA glyA APT86613.1 APT86613.1 thrB thrB APT86680.1 APT86680.1 APT86949.1 APT86949.1 APT87134.1 APT87134.1 ilvA ilvA gcvP gcvP gcvT gcvT gcvH gcvH APT87244.1 APT87244.1 APT87502.1 APT87502.1 serB serB lpdA-2 lpdA-2 APT87917.1 APT87917.1 trpB trpB trpA trpA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APT85887.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (529 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (587 aa)
lysCAspartate kinase; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family. (421 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
lpdADihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
APT86189.1Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
solAAmino acid oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
dsdAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (430 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (376 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
APT86613.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
APT86680.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
APT86949.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (469 aa)
APT87134.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (369 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (427 aa)
gcvPGlycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvP family. (949 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (370 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
APT87244.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
APT87502.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
serBPhosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
lpdA-2E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
APT87917.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (404 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (291 aa)
Your Current Organism:
Corynebacterium flavescens
NCBI taxonomy Id: 28028
Other names: ATCC 10340, C. flavescens, CCUG 28791, CIP 69.5, DSM 20296, IFO 14136, LMG 4046, LMG:4046, Microbacterium flavum , Mycobacterium flavum, NBRC 14136, NCCB 42012, NCIB 8707, NCIB:8707, NCIMB 8707
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.