node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APT85781.1 | folD | CFLV_00165 | CFLV_02700 | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
APT85781.1 | gcvT | CFLV_00165 | CFLV_08480 | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
APT85781.1 | glyA | CFLV_00165 | CFLV_04605 | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
APT85781.1 | thyA | CFLV_00165 | CFLV_04005 | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.920 |
APT85781.1 | thyX | CFLV_00165 | CFLV_07495 | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.925 |
APT86428.1 | fhs | CFLV_04000 | CFLV_06375 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.925 |
APT86428.1 | fmt | CFLV_04000 | CFLV_06710 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.933 |
APT86428.1 | gcvT | CFLV_04000 | CFLV_08480 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.913 |
APT86428.1 | glyA | CFLV_04000 | CFLV_04605 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
APT86428.1 | purH | CFLV_04000 | CFLV_04085 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
APT86428.1 | purN | CFLV_04000 | CFLV_04080 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.915 |
APT86428.1 | thyA | CFLV_04000 | CFLV_04005 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
APT86428.1 | thyX | CFLV_04000 | CFLV_07495 | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.984 |
APT86463.1 | folD | CFLV_04205 | CFLV_02700 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.925 |
APT86463.1 | purN | CFLV_04205 | CFLV_04080 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |
fhs | APT86428.1 | CFLV_06375 | CFLV_04000 | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family. | 0.925 |
fhs | folD | CFLV_06375 | CFLV_02700 | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | gcvT | CFLV_06375 | CFLV_08480 | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.942 |
fhs | glyA | CFLV_06375 | CFLV_04605 | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.962 |
fhs | purH | CFLV_06375 | CFLV_04085 | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.977 |