STRINGSTRING
leuA leuA cysH cysH ARJ28721.1 ARJ28721.1 cysI cysI ARJ28728.1 ARJ28728.1 ARJ28737.1 ARJ28737.1 rocA rocA ARJ28891.1 ARJ28891.1 ARJ29057.1 ARJ29057.1 glyA glyA ARJ29279.1 ARJ29279.1 ilvA ilvA leuD leuD carB carB ARJ29867.1 ARJ29867.1 ARJ29855.1 ARJ29855.1 ARJ29854.1 ARJ29854.1 ARJ29853.1 ARJ29853.1 thrB thrB ARJ29821.1 ARJ29821.1 ARJ29805.1 ARJ29805.1 lysA lysA ARJ29777.1 ARJ29777.1 dapD dapD dapB dapB leuC leuC leuB leuB dapA dapA ilvC ilvC ARJ29295.1 ARJ29295.1 ARJ29296.1 ARJ29296.1 ilvD ilvD ARJ29357.1 ARJ29357.1 ARJ29503.1 ARJ29503.1 ARJ29504.1 ARJ29504.1 mtnN mtnN argR argR proC proC trpD trpD asd asd trpC trpC trpF trpF trpB trpB trpA trpA ARJ29772.1 ARJ29772.1 serS serS ARJ30752.1 ARJ30752.1 ARJ30885.1 ARJ30885.1 ARJ30692.1 ARJ30692.1 ARJ30691.1 ARJ30691.1 cysK cysK ARJ30633.1 ARJ30633.1 ARJ30613.1 ARJ30613.1 ARJ30607.1 ARJ30607.1 tdcB tdcB argH argH argG argG folD folD carA carA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (243 aa)
ARJ28721.1Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (614 aa)
cysISulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (572 aa)
ARJ28728.1dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
ARJ28737.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
rocACatalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. RocA subfamily. (514 aa)
ARJ28891.1FMN-binding glutamate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (525 aa)
ARJ29057.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
ARJ29279.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (382 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (189 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1057 aa)
ARJ29867.1Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
ARJ29855.1Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (457 aa)
ARJ29854.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
ARJ29853.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa)
ARJ29821.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
ARJ29805.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa)
ARJ29777.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (239 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (241 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (456 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (346 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
ARJ29295.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (77 aa)
ARJ29296.1Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (562 aa)
ARJ29357.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
ARJ29503.1Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (539 aa)
ARJ29504.1Aminotransferase class V; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (228 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (150 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (333 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (261 aa)
trpFPhosphoribosylanthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (211 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (246 aa)
ARJ29772.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (400 aa)
serSserine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa)
ARJ30752.15-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (742 aa)
ARJ30885.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
ARJ30692.1Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1498 aa)
ARJ30691.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (491 aa)
cysKCysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
ARJ30633.1Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
ARJ30613.1N-acetyl-L,L-diaminopimelate deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
ARJ30607.1Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
tdcBSerine/threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (346 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
argGArgininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
carACarbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
Your Current Organism:
Staphylococcus lugdunensis
NCBI taxonomy Id: 28035
Other names: ATCC 43809, CCUG 25348, CIP 103642, DSM 4804, LMG 13346, LMG:13346, NCTC 12217, NRRL B-14774, S. lugdunensis, strain N860297
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