STRINGSTRING
ARJ28604.1 ARJ28604.1 ARJ28630.1 ARJ28630.1 ARJ28735.1 ARJ28735.1 betA betA ARJ28829.1 ARJ28829.1 sdaAA sdaAA lpdA lpdA ARJ28933.1 ARJ28933.1 gpmA gpmA glyA glyA ilvA ilvA ARJ29503.1 ARJ29503.1 gcvT gcvT gcvPA gcvPA gcvPB gcvPB ARJ29686.1 ARJ29686.1 trpB trpB trpA trpA ARJ29772.1 ARJ29772.1 asd asd thrB thrB ARJ29853.1 ARJ29853.1 ARJ29854.1 ARJ29854.1 ARJ29855.1 ARJ29855.1 ARJ29866.1 ARJ29866.1 ARJ30051.1 ARJ30051.1 gcvH gcvH gpmI gpmI B6N84_10325 B6N84_10325 tdcB tdcB ARJ30612.1 ARJ30612.1 ARJ30704.1 ARJ30704.1 ARJ30732.1 ARJ30732.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARJ28604.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
ARJ28630.1Glycine cleavage system protein H; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
ARJ28735.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (496 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (568 aa)
ARJ28829.1L-serine dehydratase, iron-sulfur-dependent subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (226 aa)
sdaAAL-serine dehydratase, iron-sulfur-dependent subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (298 aa)
lpdADihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
ARJ28933.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (391 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (228 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa)
ARJ29503.1Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (539 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
gcvPAGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (449 aa)
gcvPBGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (491 aa)
ARJ29686.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (246 aa)
ARJ29772.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (400 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa)
ARJ29853.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
ARJ29854.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
ARJ29855.1Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (457 aa)
ARJ29866.1Low specificity L-threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
ARJ30051.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
gcvHGlycine cleavage system protein H; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (126 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (506 aa)
B6N84_10325Hypothetical protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
tdcBSerine/threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (346 aa)
ARJ30612.1Glycine C-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
ARJ30704.1Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
ARJ30732.1Histidine phosphatase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
Your Current Organism:
Staphylococcus lugdunensis
NCBI taxonomy Id: 28035
Other names: ATCC 43809, CCUG 25348, CIP 103642, DSM 4804, LMG 13346, LMG:13346, NCTC 12217, NRRL B-14774, S. lugdunensis, strain N860297
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.