STRINGSTRING
GU90_10270 GU90_10270 GU90_18300 GU90_18300 GU90_18680 GU90_18680 GU90_07420 GU90_07420 GU90_07390 GU90_07390 GU90_06550 GU90_06550 purU purU GU90_05805 GU90_05805 GU90_18685 GU90_18685 GU90_18690 GU90_18690 GU90_18695 GU90_18695 gcvH-2 gcvH-2 GU90_10750 GU90_10750 GU90_10805 GU90_10805 GU90_11115 GU90_11115 GU90_11120 GU90_11120 GU90_11745 GU90_11745 gsr7 gsr7 GU90_12330 GU90_12330 GU90_12695 GU90_12695 GU90_12700 GU90_12700 GU90_12705 GU90_12705 GU90_10205 GU90_10205 gcvT gcvT glyA glyA GU90_09320 GU90_09320 GU90_09195 GU90_09195 GU90_08490 GU90_08490 GU90_08305 GU90_08305 GU90_07835 GU90_07835 gsr18 gsr18 mdh mdh GU90_13035 GU90_13035 GU90_13090 GU90_13090 acnA acnA GU90_07430 GU90_07430 gcvP gcvP gcvH gcvH GU90_13850 GU90_13850 GU90_01120 GU90_01120 GU90_01395 GU90_01395 GU90_02310 GU90_02310 GU90_02450 GU90_02450 GU90_03160 GU90_03160 GU90_03280 GU90_03280 GU90_03320 GU90_03320 GU90_03550 GU90_03550 GU90_04320 GU90_04320 katE katE GU90_04625 GU90_04625 GU90_04985 GU90_04985 GU90_04990 GU90_04990 GU90_04995 GU90_04995 GU90_05055 GU90_05055 GU90_05570 GU90_05570 GU90_07515 GU90_07515 gsr3 gsr3 acsA acsA GU90_16895 GU90_16895 GU90_18290 GU90_18290 GU90_10320 GU90_10320 GU90_10275 GU90_10275
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GU90_10270methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (734 aa)
GU90_18300Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
GU90_18680acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
GU90_07420methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
GU90_07390Arsenate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (118 aa)
GU90_06550Peptidase U61; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa)
GU90_05805MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
GU90_18685Glycolate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
GU90_18690FAD-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
GU90_18695Glycolate oxidase subunit GlcD; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
gcvH-2Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
GU90_10750Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
GU90_10805Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
GU90_11115Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
GU90_11120Keto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
GU90_11745Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (765 aa)
gsr7Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
GU90_12330acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (677 aa)
GU90_12695Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
GU90_12700Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (901 aa)
GU90_127054Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
GU90_10205Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (367 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
GU90_09320Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
GU90_09195Catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
GU90_08490acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
GU90_08305Glyoxylate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
GU90_07835AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)
gsr18Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
GU90_130352-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
GU90_13090Dimethylmenaquinone methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (951 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (935 aa)
GU90_07430acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (587 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (965 aa)
gcvHHypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
GU90_13850FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
GU90_01120acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (423 aa)
GU90_01395Metal-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
GU90_02310acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
GU90_02450Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
GU90_03160Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
GU90_03280Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (375 aa)
GU90_03320Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (434 aa)
GU90_03550UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
GU90_04320Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (447 aa)
katEHydroperoxidase; Serves to protect cells from the toxic effects of hydrogen peroxide. (706 aa)
GU90_04625propionyl-CoA carboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
GU90_04985Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (378 aa)
GU90_04990Tartronate semialdehyde reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
GU90_04995Hydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (269 aa)
GU90_05055Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (530 aa)
GU90_05570Dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
GU90_07515acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
gsr3Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (485 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
GU90_16895acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (372 aa)
GU90_18290acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
GU90_10320Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (397 aa)
GU90_10275methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (621 aa)
Your Current Organism:
Saccharopolyspora rectivirgula
NCBI taxonomy Id: 28042
Other names: ATCC 33515, DSM 43747, Faenia rectivirgula, IFO 12464, INMI 683, JCM 3057, Micropolyspora faeni, Micropolyspora rectivirgula, NBRC 12464, NRRL B-16280, S. rectivirgula, Thermopolyspora polyspora, Thermopolyspora rectivirgula, VKM Ac-810
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.