STRINGSTRING
lpxK lpxK lpxD lpxD lpxC lpxC KXO14680.1 KXO14680.1 KXO14657.1 KXO14657.1 KXO15212.1 KXO15212.1 KXO14937.1 KXO14937.1 KXO15558.1 KXO15558.1 KXO15605.1 KXO15605.1 KXO16093.1 KXO16093.1 KXO17321.1 KXO17321.1 KXO17320.1 KXO17320.1 KXO17454.1 KXO17454.1 KXO17428.1 KXO17428.1 KXO17424.1 KXO17424.1 KXO17741.1 KXO17741.1 KXO17740.1 KXO17740.1 KXO17736.1 KXO17736.1 KXO17733.1 KXO17733.1 KXO17983.1 KXO17983.1 kdsB kdsB KXO18059.1 KXO18059.1 KXO18170.1 KXO18170.1 KXO18204.1 KXO18204.1 KXO18410.1 KXO18410.1 KXO18160.1 KXO18160.1 KXO18168.1 KXO18168.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (393 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (461 aa)
KXO14680.1acyl-[acyl-carrier-protein]-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (257 aa)
KXO14657.1Hypothetical protein. (164 aa)
KXO15212.1K+-dependent Na+/Ca+ exchanger family protein; KEGG: bmh:BMWSH_5145 0.0031 spoIIE; Serine/threonine specific protein phosphatase; stage II sporulation protein E; K06382 stage II sporulation protein E; Psort location: CytoplasmicMembrane, score: 10.00. (327 aa)
KXO14937.1Reverse transcriptase; KEGG: acm:AciX9_2572 5.2e-148 RNA-directed DNA polymerase; Psort location: Cytoplasmic, score: 8.96. (558 aa)
KXO15558.1Hypothetical protein; KEGG: spi:MGAS10750_Spy1709 3.0e-42 Reverse transcriptase / RNA maturase / endonuclease; K00986 RNA-directed DNA polymerase K01175. (164 aa)
KXO15605.1Hypothetical protein. (216 aa)
KXO16093.1KEGG: pmz:HMPREF0659_A5478 1.7e-110 putative acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase; K00677 UDP-N-acetylglucosamine acyltransferase; Psort location: Cytoplasmic, score: 9.97. (260 aa)
KXO17321.1KEGG: pmz:HMPREF0659_A5656 2.2e-110 kdsA; 3-deoxy-8-phosphooctulonate synthase K01627; Psort location: Cytoplasmic, score: 9.97; Belongs to the KdsA family. (252 aa)
KXO17320.1KEGG: pmz:HMPREF0659_A5655 1.2e-141 putative arabinose 5-phosphate isomerase; K06041 arabinose-5-phosphate isomerase; Belongs to the SIS family. GutQ/KpsF subfamily. (324 aa)
KXO17454.1Heptosyltransferase; KEGG: gfo:GFO_3278 1.6e-57 RfaQ-like lipopolysaccharide core biosynthesis glycosyl transferase K01043; Psort location: Cytoplasmic, score: 8.96. (348 aa)
KXO17428.1KEGG: pmz:HMPREF0659_A6393 8.1e-95 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; K02517 lipid A biosynthesis lauroyl acyltransferase; Psort location: Cytoplasmic, score: 8.96. (298 aa)
KXO17424.1Arylsulfatase; KEGG: cco:CCC13826_2111 2.5e-54 phosphoribosylformylglycinamidine cyclo-ligase; Psort location: CytoplasmicMembrane, score: 10.00. (559 aa)
KXO17741.1Glycosyltransferase, family 8; KEGG: bfr:BF0225 4.0e-31 lipopolysaccharide 1,2-glucosyltransferase; K05945. (324 aa)
KXO17740.1KEGG: pdn:HMPREF9137_1386 6.0e-83 glycosyltransferase group 2 family protein; Psort location: CytoplasmicMembrane, score: 7.88. (290 aa)
KXO17736.1LICD family protein; KEGG: smb:smi_1230 5.4e-34 licD1; phosphorylcholine transferase LicD1; K07271 lipopolysaccharide cholinephosphotransferase; Psort location: Cytoplasmic, score: 8.96. (283 aa)
KXO17733.1KEGG: stj:SALIVA_1042 1.0e-23 epsJ; glycosyl transferase family protein; Psort location: CytoplasmicMembrane, score: 7.88. (359 aa)
KXO17983.1lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (247 aa)
KXO18059.1KEGG: pmz:HMPREF0659_A6733 2.7e-71 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270; Psort location: Cytoplasmic, score: 9.97. (172 aa)
KXO18170.1LICD family protein; KEGG: pmz:HMPREF0659_A5241 8.1e-127 LICD family protein; K07271 lipopolysaccharide cholinephosphotransferase; Psort location: Cytoplasmic, score: 8.96. (277 aa)
KXO18204.13-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (406 aa)
KXO18410.1KEGG: pdn:HMPREF9137_0320 1.5e-116 Ser/Thr phosphatase family protein; K03269 UDP-2,3-diacylglucosamine hydrolase; Psort location: Cytoplasmic, score: 9.97. (254 aa)
KXO18160.1Arylsulfatase; KEGG: pmz:HMPREF0659_A5230 3.7e-218 arylsulfatase; Psort location: CytoplasmicMembrane, score: 9.99. (635 aa)
KXO18168.1KEGG: pdn:HMPREF9137_0815 2.7e-112 glycosyltransferase group 2 family protein. (326 aa)
Your Current Organism:
Prevotella bivia
NCBI taxonomy Id: 28125
Other names: ATCC 29303, Bacteroides bivius, CCUG 9557, CIP 105105, DSM 20514, JCM 6331, LMG 6452, LMG:6452, NCTC 11156, P. bivia, VPI 6822, strain 653C, strain JCVIHMP010
Server load: very high (>100%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.