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KXB31282.1 KXB31282.1 ppc ppc KXB32438.1 KXB32438.1 KXB32612.1 KXB32612.1 KXB31970.1 KXB31970.1 KXB32268.1 KXB32268.1 KXB32059.1 KXB32059.1 KXB32226.1 KXB32226.1 KXB32249.1 KXB32249.1 KXB31936.1 KXB31936.1 KXB31655.1 KXB31655.1 KXB31656.1 KXB31656.1 KXB31657.1 KXB31657.1 KXB31851.1 KXB31851.1 gltA gltA sdhB sdhB KXB30816.1 KXB30816.1 KXB30817.1 KXB30817.1 KXB31227.1 KXB31227.1 mdh mdh KXB30885.1 KXB30885.1 KXB30890.1 KXB30890.1 KXB30899.1 KXB30899.1 KXB30901.1 KXB30901.1 nuoN nuoN KXB30909.1 KXB30909.1 KXB30910.1 KXB30910.1 nuoK nuoK nuoI nuoI nuoH nuoH KXB30915.1 KXB30915.1 KXB30917.1 KXB30917.1 KXB30995.1 KXB30995.1 KXB30998.1 KXB30998.1 aspA aspA KXB31083.1 KXB31083.1 KXB31262.1 KXB31262.1 KXB30596.1 KXB30596.1 KXB30094.1 KXB30094.1 KXB30224.1 KXB30224.1 aceK aceK KXB30623.1 KXB30623.1 KXB30629.1 KXB30629.1 KXB30403.1 KXB30403.1 KXB30518.1 KXB30518.1 KXB30521.1 KXB30521.1 KXB29355.1 KXB29355.1 KXB29535.1 KXB29535.1 KXB29537.1 KXB29537.1 KXB29551.1 KXB29551.1 KXB29618.1 KXB29618.1 ubiE ubiE KXB29796.1 KXB29796.1 KXB29797.1 KXB29797.1 KXB29798.1 KXB29798.1 KXB29804.1 KXB29804.1 fumC fumC KXB29209.1 KXB29209.1 KXB29210.1 KXB29210.1 KXB29060.1 KXB29060.1 KXB29062.1 KXB29062.1 KXB31284.1 KXB31284.1 KXB31343.1 KXB31343.1 sucC sucC sucD sucD KXB31462.1 KXB31462.1 KXB30665.1 KXB30665.1 KXB30666.1 KXB30666.1 sucA sucA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KXB31282.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (920 aa)
KXB32438.1Cytochrome B; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (433 aa)
KXB32612.1Aconitate hydratase B; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (762 aa)
KXB31970.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (548 aa)
KXB32268.1Hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
KXB32059.1Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
KXB32226.1Malate synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (532 aa)
KXB32249.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
KXB31936.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
KXB31655.1NADH-ubiquinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
KXB31656.1NADH-quinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
KXB31657.1NADH-quinone oxidoreductase subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
KXB31851.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (432 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
KXB30816.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (594 aa)
KXB30817.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
KXB31227.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
KXB30885.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
KXB30890.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
KXB30899.1NADP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (487 aa)
KXB30901.1NADP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
nuoNNADH:ubiquinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (492 aa)
KXB30909.1NADH:ubiquinone oxidoreductase subunit M; Catalyzes the transfer of electrons from NADH to quinone; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
KXB30910.1NADH:ubiquinone oxidoreductase subunit L; Derived by automated computational analysis using gene prediction method: Protein Homology. (678 aa)
nuoKNADH-quinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (103 aa)
nuoINADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (162 aa)
nuoHNADH:ubiquinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (349 aa)
KXB30915.1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (776 aa)
KXB30917.1NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
KXB30995.1Nitric oxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the heme-copper respiratory oxidase family. (459 aa)
KXB30998.1Cytochrome-c oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
aspAClass II fumarate hydratase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
KXB31083.1Phosphatidylethanolamine N-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
KXB31262.12-hydroxy-acid oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
KXB30596.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (538 aa)
KXB30094.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
KXB30224.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (745 aa)
aceKBifunctional isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (590 aa)
KXB30623.1Cytochrome C oxidase subunit III; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
KXB30629.1Glycolate oxidase subunit GlcD; Derived by automated computational analysis using gene prediction method: Protein Homology. (493 aa)
KXB30403.1Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
KXB30518.1Cytochrome C oxidase Cbb3; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. (299 aa)
KXB30521.1Cytochrome C oxidase Cbb3; CcoN; FixN; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the heme-copper respiratory oxidase family. (475 aa)
KXB29355.1Histidine kinase; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (145 aa)
KXB29535.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
KXB29537.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
KXB29551.1(Fe-S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
KXB29618.1Dimethylmenaquinone methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
ubiEUbiquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (245 aa)
KXB29796.1Uptake hydrogenase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
KXB29797.1Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (598 aa)
KXB29798.1Ni/Fe hydrogenase 1 b-type cytochrome subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
KXB29804.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
fumCClass II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
KXB29209.1HupU protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
KXB29210.1HupV protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
KXB29060.1Quinol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
KXB29062.1Nitrate reductase; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (162 aa)
KXB31284.1Cytochrome oxidase subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (531 aa)
KXB31343.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
KXB31462.1Transglutaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
KXB30665.1Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
KXB30666.1Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
sucASucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (944 aa)
Your Current Organism:
Dechloromonas denitrificans
NCBI taxonomy Id: 281362
Other names: ATCC BAA-841, D. denitrificans, DSM 15892, Dechloromonas denitrificans Horn et al. 2005, strain ED1
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