STRINGSTRING
dapD dapD mtnN mtnN dapB dapB AKE93229.1 AKE93229.1 thrB thrB AKE93231.1 AKE93231.1 metE metE dapF dapF AKE93732.1 AKE93732.1 AKE93733.1 AKE93733.1 AKE93734.1 AKE93734.1 asd asd metAS metAS AKE94299.1 AKE94299.1 AKE94313.1 AKE94313.1 AKE94342.1 AKE94342.1 AKE94506.1 AKE94506.1 metK metK lysA lysA luxS luxS dapA dapA AKE95627.1 AKE95627.1 AKE95674.1 AKE95674.1 AKE96029.1 AKE96029.1 AKE96214.1 AKE96214.1 AKE96996.1 AKE96996.1 AKE96997.1 AKE96997.1 AKE97161.1 AKE97161.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] (232 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
AKE93229.1Threonine synthase. (429 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
AKE93231.1Aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa)
AKE93732.15,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (301 aa)
AKE93733.1Aspartokinase/homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
AKE93734.1Cystathionine gamma-synthase. (384 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
metASHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
AKE94299.1B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
AKE94313.1Aspartate kinase; Belongs to the aspartokinase family. (450 aa)
AKE94342.1Aromatic amino acid aminotransferase. (397 aa)
AKE94506.1Cystathionine beta-lyase. (395 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
AKE95627.1Hypothetical protein. (383 aa)
AKE95674.1Hypothetical protein. (164 aa)
AKE96029.15- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase. (367 aa)
AKE96214.1Protein MalY. (389 aa)
AKE96996.1Cystathionine beta-lyase. (381 aa)
AKE96997.1Cystathionine beta-lyase. (456 aa)
AKE97161.1Homocysteine methyltransferase. (310 aa)
Your Current Organism:
Cronobacter sakazakii
NCBI taxonomy Id: 28141
Other names: ATCC 29544, C. sakazakii, CCUG 14558, CDC 4562-70 (78-067947), CIP 103183, Cronobacter sakazakii subsp. sakazakii, DSM 4485, Enterobacter sakazakii, LMG 5740, LMG:5740, NBRC 102416, NCTC 11467, yellow -pigmented Enterobacter cloacae
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