STRINGSTRING
rcsF rcsF AKE93037.1 AKE93037.1 lpxB lpxB lpxA lpxA fabZ fabZ lpxD lpxD AKE93055.1 AKE93055.1 bamA bamA lpxC lpxC lptD lptD AKE93282.1 AKE93282.1 AKE93356.1 AKE93356.1 AKE93357.1 AKE93357.1 AKE93523.1 AKE93523.1 AKE93524.1 AKE93524.1 AKE93525.1 AKE93525.1 mlaD mlaD AKE93527.1 AKE93527.1 AKE93528.1 AKE93528.1 AKE93529.1 AKE93529.1 AKE93530.1 AKE93530.1 AKE93531.1 AKE93531.1 lptC lptC lptA lptA AKE93534.1 AKE93534.1 AKE93536.1 AKE93536.1 AKE93537.1 AKE93537.1 rapZ rapZ AKE93561.1 AKE93561.1 AKE93562.1 AKE93562.1 AKE93986.1 AKE93986.1 AKE94064.1 AKE94064.1 AKE94507.1 AKE94507.1 AKE94508.1 AKE94508.1 AKE94633.1 AKE94633.1 bamE bamE bamD bamD bamC bamC lpxM lpxM AKE95733.1 AKE95733.1 kdsA kdsA AKE95800.1 AKE95800.1 slyB slyB AKE96327.1 AKE96327.1 AKE96520.1 AKE96520.1 lolD lolD AKE96522.1 AKE96522.1 lpxL lpxL AKE96645.1 AKE96645.1 kdsB kdsB lpxK lpxK ompX ompX cpoB cpoB pal pal tolB tolB AKE96846.1 AKE96846.1 tolR tolR tolQ tolQ AKE96849.1 AKE96849.1 lptE lptE AKE96992.1 AKE96992.1 lpxH lpxH lpxP lpxP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rcsFOuter membrane lipoprotein; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (134 aa)
AKE93037.1Hypothetical protein. (235 aa)
lpxBLipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (380 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
fabZhydroxymyristoyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (151 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa)
AKE93055.1Hypothetical protein; Belongs to the skp family. (164 aa)
bamAOuter membrane protein assembly factor YaeT; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (804 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa)
lptDOuter membrane protein Imp; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (787 aa)
AKE93282.1Siderophore-iron reductase FhuF. (262 aa)
AKE93356.1Lipopolysaccharide ABC transporter permease LptG. (360 aa)
AKE93357.1Lipopolysaccharide ABC transporter permease LptF. (370 aa)
AKE93523.1Hypothetical protein; Belongs to the BolA/IbaG family. (85 aa)
AKE93524.1Sulfate transporter. (100 aa)
AKE93525.1Organic solvent ABC transporter substrate-binding protein. (211 aa)
mlaDPutative phospholipid ABC transporter substrate-binding protein. (183 aa)
AKE93527.1ABC transporter permease. (260 aa)
AKE93528.1Rganic solvent ABC transporter ATP-binding protein. (271 aa)
AKE93529.1Na+/Ca+ antiporter. (325 aa)
AKE93530.1D-arabinose 5-phosphate isomerase. (334 aa)
AKE93531.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (188 aa)
lptCLipopolysaccharide export system protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (191 aa)
lptALipopolysaccharide transport periplasmic protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (185 aa)
AKE93534.1Lipopolysaccharide ABC transporter ATP-binding protein. (241 aa)
AKE93536.1Sigma-54 modulation protein. (95 aa)
AKE93537.1PTS sugar transporter subunit IIA. (177 aa)
rapZATP-binding protein; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. (289 aa)
AKE93561.1Serine endoprotease; Belongs to the peptidase S1C family. (455 aa)
AKE93562.1Serine endoprotease. (355 aa)
AKE93986.13-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (424 aa)
AKE94064.1Outer membrane lipoprotein. (220 aa)
AKE94507.1Biopolymer transporter. (244 aa)
AKE94508.1Biopolymer transporter. (141 aa)
AKE94633.1Mechanosensitive channel protein. (312 aa)
bamEOuter membrane biogenesis protein BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (114 aa)
bamDOuter membrane protein assembly complex subunit YfiO; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
bamCLipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa)
lpxMLipid A biosynthesis (KDO) 2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa)
AKE95733.1Ferrioxamine receptor. (705 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (284 aa)
AKE95800.1Transporter protein TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (246 aa)
slyBOuter membrane lipoprotein SlyB. (155 aa)
AKE96327.1Major outer membrane lipoprotein. (78 aa)
AKE96520.1Outer membrane-specific lipoprotein transporter subunit LolE. (414 aa)
lolDLipoprotein-releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. (234 aa)
AKE96522.1Outer membrane-specific lipoprotein transporter subunit LolC. (399 aa)
lpxLLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
AKE96645.1Outer membrane protein A; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (358 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa)
ompXOuter membrane protein X. (170 aa)
cpoBTol-pal system protein YbgF; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (265 aa)
palPeptidoglycan-associated outer membrane lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (172 aa)
tolBTranslocation protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (430 aa)
AKE96846.1Cell envelope integrity inner membrane protein TolA. (422 aa)
tolRColicin uptake protein TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa)
tolQColicin uptake protein TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (232 aa)
AKE96849.1acyl-CoA thioester hydrolase YbgC. (134 aa)
lptELPS-assembly lipoprotein RlpB; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (198 aa)
AKE96992.1Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa)
lpxPLipid A biosynthesis palmotoleoyl acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (307 aa)
Your Current Organism:
Cronobacter sakazakii
NCBI taxonomy Id: 28141
Other names: ATCC 29544, C. sakazakii, CCUG 14558, CDC 4562-70 (78-067947), CIP 103183, Cronobacter sakazakii subsp. sakazakii, DSM 4485, Enterobacter sakazakii, LMG 5740, LMG:5740, NBRC 102416, NCTC 11467, yellow -pigmented Enterobacter cloacae
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