STRINGSTRING
AKE93157.1 AKE93157.1 AKE97202.1 AKE97202.1 dxs dxs AKE97052.1 AKE97052.1 AKE96996.1 AKE96996.1 AKE96959.1 AKE96959.1 AKE96955.1 AKE96955.1 AKE96862.1 AKE96862.1 bioA bioA bioF bioF AKE96717.1 AKE96717.1 serC serC AKE96668.1 AKE96668.1 AKE96655.1 AKE96655.1 AKE96544.1 AKE96544.1 argD-2 argD-2 sufS sufS AKE96214.1 AKE96214.1 AKE96163.1 AKE96163.1 AKE95893.1 AKE95893.1 AKE95735.1 AKE95735.1 AKE95724.1 AKE95724.1 AKE95627.1 AKE95627.1 AKE95477.1 AKE95477.1 hisC hisC menD menD AKE95194.1 AKE95194.1 alsS alsS AKE95020.1 AKE95020.1 AKE95015.1 AKE95015.1 iscS iscS glyA glyA AKE94840.1 AKE94840.1 AKE94711.1 AKE94711.1 lysA lysA AKE94654.1 AKE94654.1 AKE94612.1 AKE94612.1 AKE94506.1 AKE94506.1 AKE94342.1 AKE94342.1 AKE94341.1 AKE94341.1 AKE94299.1 AKE94299.1 argD argD AKE94172.1 AKE94172.1 AKE94163.1 AKE94163.1 AKE94135.1 AKE94135.1 AKE94134.1 AKE94134.1 AKE94039.1 AKE94039.1 kbl kbl AKE93784.1 AKE93784.1 AKE93734.1 AKE93734.1 AKE93708.1 AKE93708.1 ilvA ilvA patA patA AKE93319.1 AKE93319.1 AKE93229.1 AKE93229.1 AKE93169.1 AKE93169.1 hemL hemL btuF btuF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKE93157.1Acetolactate synthase large subunit. (574 aa)
AKE97202.13D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; Belongs to the TPP enzyme family. (646 aa)
dxs1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa)
AKE97052.1GntR family transcriptional regulator. (473 aa)
AKE96996.1Cystathionine beta-lyase. (381 aa)
AKE96959.1Enterobactin synthetase subunit F. (1305 aa)
AKE96955.1Methionine aminotransferase. (386 aa)
AKE96862.12-oxoglutarate dehydrogenase E1 component. (935 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (430 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (383 aa)
AKE96717.1Pyruvate dehydrogenase; Belongs to the TPP enzyme family. (572 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
AKE96668.1Aromatic amino acid aminotransferase. (396 aa)
AKE96655.1Hypothetical protein. (368 aa)
AKE96544.1Aminodeoxychorismate lyase. (266 aa)
argD-2Bifunctional succinylornithine transaminase/acetylornithine transaminase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa)
sufSBifunctional cysteine desulfurase/selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
AKE96214.1Protein MalY. (389 aa)
AKE96163.1HTH-type transcriptional regulator YdcR. (473 aa)
AKE95893.1Pyruvate-flavodoxin oxidoreductase. (1173 aa)
AKE95735.1Hypothetical protein. (463 aa)
AKE95724.1Alanine racemase II; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa)
AKE95627.1Hypothetical protein. (383 aa)
AKE95477.14-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa)
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (555 aa)
AKE95194.1Aminotransferase AlaT. (404 aa)
alsSAcetolactate synthase; Belongs to the TPP enzyme family. (559 aa)
AKE95020.1Aminotransferase. (413 aa)
AKE95015.1Indole-3-pyruvate decarboxylase. (554 aa)
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
AKE94840.1Thiamine pyrophosphate protein; Belongs to the TPP enzyme family. (598 aa)
AKE94711.1FeS_syn_CsdA domain-containing protein. (401 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
AKE94654.1Putative global regulator; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. (329 aa)
AKE94612.1Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (237 aa)
AKE94506.1Cystathionine beta-lyase. (395 aa)
AKE94342.1Aromatic amino acid aminotransferase. (397 aa)
AKE94341.1Alanine racemase I; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa)
AKE94299.1B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
argDN-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (429 aa)
AKE94172.1Maltose phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (800 aa)
AKE94163.1Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (815 aa)
AKE94135.14-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
AKE94134.1GntT family transcriptional regulator. (497 aa)
AKE94039.1Valine-pyruvate aminotransferase. (418 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
AKE93784.1Putative 6-N-hydroxylaminopurine resistance protein. (225 aa)
AKE93734.1Cystathionine gamma-synthase. (384 aa)
AKE93708.1Acetolactate synthase large subunit. (548 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (515 aa)
patAPutrescine aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (465 aa)
AKE93319.1gntR family transcriptional regulator. (521 aa)
AKE93229.1Threonine synthase. (429 aa)
AKE93169.1Thiamine ABC transporter substrate-binding protein. (327 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (426 aa)
btuFPutative vitamin B12 ABC transporter; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (266 aa)
Your Current Organism:
Cronobacter sakazakii
NCBI taxonomy Id: 28141
Other names: ATCC 29544, C. sakazakii, CCUG 14558, CDC 4562-70 (78-067947), CIP 103183, Cronobacter sakazakii subsp. sakazakii, DSM 4485, Enterobacter sakazakii, LMG 5740, LMG:5740, NBRC 102416, NCTC 11467, yellow -pigmented Enterobacter cloacae
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