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hemN hemN dusA dusA rpe rpe CCO58151.1 CCO58151.1 CCO58223.1 CCO58223.1 CCO58241.1 CCO58241.1 hisF hisF hisA hisA bioB bioB pyrF pyrF dusC dusC kdsA kdsA lipA lipA CCO58784.1 CCO58784.1 CCO58785.1 CCO58785.1 nanE-2 nanE-2 guaB guaB rlmN rlmN leuA leuA CCO59253.1 CCO59253.1 dusB dusB hemB hemB NAMPT NAMPT CCO61811.1 CCO61811.1 aroG aroG eda-2 eda-2 eda eda xenB xenB nanE nanE guaC guaC nrdG nrdG talB talB kbaZ-2 kbaZ-2 kbaY-2 kbaY-2 CCO60759.1 CCO60759.1 lldD lldD aslB aslB aroH-2 aroH-2 CCO60347.1 CCO60347.1 CCO60330.1 CCO60330.1 CCO60262.1 CCO60262.1 CCO60250.1 CCO60250.1 CCO60116.1 CCO60116.1 CCO59885.1 CCO59885.1 thiE-2 thiE-2 thiG thiG thiH thiH tpiA tpiA CCO56266.1 CCO56266.1 fbaA fbaA pdxJ pdxJ oadA oadA nadC nadC gltB gltB gltA gltA aroF aroF CCO56671.1 CCO56671.1 deoC deoC dapA dapA fadH fadH moaA moaA kbaY kbaY kbaZ kbaZ CCO57185.1 CCO57185.1 pflA pflA trpA trpA trpC trpC CCO57419.1 CCO57419.1 CCO57463.1 CCO57463.1 thiE thiE CCO57861.1 CCO57861.1 pyrD pyrD aroH aroH queE queE ulaD ulaD CCO58065.1 CCO58065.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hemNOxygen-independent coproporphyrinogen-III oxidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
dusAtRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (334 aa)
rpeRibulose-phosphate 3-epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa)
CCO58151.1Putative DhnA-type fructose-1,6-bisphosphate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (277 aa)
CCO58223.1Putative Fructokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (647 aa)
CCO58241.1Putative Ketose-bisphosphate aldolase, class-II; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (276 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (245 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (350 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa)
dusCtRNA-dihydrouridine synthase C; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (318 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the KdsA family. (283 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
CCO58784.1Putative N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (289 aa)
CCO58785.1Putative N-acetylneuraminate lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (300 aa)
nanE-2Putative N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (232 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (372 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa)
CCO59253.1Putative Lysine 2,3-aminomutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (340 aa)
dusBtRNA-dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (322 aa)
hemBDelta-aminolevulinic acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. (348 aa)
NAMPTNicotinamide phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAPRTase family. (463 aa)
CCO61811.1Putative aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (279 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (349 aa)
eda-2KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (209 aa)
eda2-dehydro-3-deoxyphosphogluconate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (210 aa)
xenBXenobiotic reductase B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (356 aa)
nanEPutative N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (241 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (155 aa)
talBTransaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
kbaZ-2D-tagatose-1,6-bisphosphate aldolase subunit kbaZ; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (426 aa)
kbaY-2D-tagatose-1,6-bisphosphate aldolase subunit kbaY; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (285 aa)
CCO60759.1Putative phospho-carbohydrate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (218 aa)
lldDL-lactate dehydrogenase [cytochrome]; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (380 aa)
aslBAnaerobic sulfatase-maturating enzyme homolog aslB; Function of homologous gene experimentally demonstrated in an other organism; regulator. (400 aa)
aroH-2Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
CCO60347.1Putative glutamate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the glutamate synthase family. (513 aa)
CCO60330.1Putative (2R)-phospho-3-sulfolactate synthase (ComA); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (277 aa)
CCO60262.1Putative Aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (389 aa)
CCO60250.1Putative aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (216 aa)
CCO60116.1Putative Dihydrodipicolinate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DapA family. (296 aa)
CCO59885.1Putative glutamate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1818 aa)
thiE-2Putative Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (397 aa)
thiGThiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (253 aa)
thiHThiazole biosynthesis protein thiH; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (370 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa)
CCO56266.1Putative oxygen-independent coproporphyrinogen III oxidase hemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (391 aa)
fbaAFructose-bisphosphate aldolase class 2; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa)
oadAOxaloacetate decarboxylase alpha chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (594 aa)
nadCNicotinate-nucleotide pyrophosphorylase [carboxylating]; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family. (295 aa)
gltBGlutamate synthase [NADPH] large chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1487 aa)
gltAGlutamate synthase [NADPH] large chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1513 aa)
aroFPhospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa)
CCO56671.1Putative Fructose-bisphosphate aldolase class 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (290 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (258 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
fadH2,4-dienoyl-CoA reductase [NADPH]; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (667 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (335 aa)
kbaYD-tagatose-1,6-bisphosphate aldolase subunit kbaY; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (284 aa)
kbaZD-tagatose-1,6-bisphosphate aldolase subunit kbaZ; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (435 aa)
CCO57185.1Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (272 aa)
pflAPyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
trpCTryptophan biosynthesis protein trpCF [Includes: Indole-3-glycerol phosphate synthase; Function experimentally demonstrated in the studied genus; enzyme; Belongs to the TrpC family. (465 aa)
CCO57419.1Putative Dihydrodipicolinate synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the DapA family. (305 aa)
CCO57463.1Putative Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (400 aa)
thiEPutative Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (209 aa)
CCO57861.1Putative 2-dehydro-3-deoxyphosphogalactonate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (218 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
aroHPhospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa)
queEPutative Queuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (226 aa)
ulaD3-keto-L-gulonate-6-phosphate decarboxylase ulaD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (216 aa)
CCO58065.1Putative Arylsulfatase regulator (Fe-S oxidoreductase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (351 aa)
Your Current Organism:
Vibrio nigripulchritudo
NCBI taxonomy Id: 28173
Other names: ATCC 27043, Beneckea nigrapulchrituda, Beneckea nigripulchritudo, CAIM 323, CCUG 28586, CIP 103195, LMG 3896, LMG:3896, V. nigripulchritudo
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