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| | echA8_2 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa) |
| | SFF96837.1 | Uncharacterized conserved protein. (137 aa) |
| | serB | Phosphoserine phosphatase. (291 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase/phosphoserine aminotransferase,TIGR01365/phosphoserine aminotransferase, putative,TIGR01366; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (926 aa) |
| | SFG02784.1 | Hypothetical protein. (185 aa) |
| | SFG04538.1 | Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (922 aa) |
| | gnl | Gluconolactonase. (298 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (289 aa) |
| | gcvT_4 | Aminomethyltransferase. (369 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (118 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (944 aa) |
| | gndA | 6-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (471 aa) |
| | mcl1 | beta-methylmalyl-CoA/L-malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (325 aa) |
| | accA | acetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | fhs | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (558 aa) |
| | glyA1 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | gdhA_2 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (475 aa) |
| | merA_2 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. (470 aa) |
| | SFG19735.1 | Hypothetical protein. (175 aa) |
| | cysE | Serine O-acetyltransferase. (272 aa) |
| | pdhC | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (442 aa) |
| | bfmBAB | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (460 aa) |
| | acoA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (339 aa) |
| | fda | Fructose-bisphosphate aldolase, class I. (296 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (392 aa) |
| | gap_3 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (359 aa) |
| | gap_2 | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | tktA | Transketolase; Belongs to the transketolase family. (676 aa) |
| | eutD | Phosphotransacetylase. (323 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa) |
| | glk | Glucokinase; Belongs to the bacterial glucokinase family. (318 aa) |
| | SFG25054.1 | Methylenetetrahydrofolate reductase (NADPH). (298 aa) |
| | icd | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | fadA_1 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa) |
| | fadJ_1 | 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase. (729 aa) |
| | glcB | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (720 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (529 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (223 aa) |
| | gntK | Gluconate kinase, SKI family. (165 aa) |
| | SFG54195.1 | Antitoxin CptB. (88 aa) |
| | ttuD_1 | Hydroxypyruvate reductase. (401 aa) |
| | SFG60261.1 | Trimethylamine---corrinoid protein Co-methyltransferase; Belongs to the trimethylamine methyltransferase family. (509 aa) |
| | scpA_2 | methylmalonyl-CoA mutase. (711 aa) |
| | accA1_1 | Biotin carboxyl carrier protein /biotin carboxylase. (669 aa) |
| | accD5 | propionyl-CoA carboxylase carboxyltransferase subunit. (510 aa) |
| | eda | 2-keto-3-deoxy-phosphogluconate aldolase. (210 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (601 aa) |
| | gltA | Citrate synthase; Belongs to the citrate synthase family. (431 aa) |
| | cysK | Cysteine synthase A. (342 aa) |
| | fumC | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | amdA | Acetamidase/formamidase. (311 aa) |
| | sbnA | Cysteine synthase A. (381 aa) |
| | vapC1 | tRNA(fMet)-specific endonuclease VapC; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (129 aa) |
| | tktB_1 | Transketolase subunit A. (284 aa) |
| | dxs_2 | Transketolase. (345 aa) |
| | fabG_7 | NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (250 aa) |
| | hprA | Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa) |
| | ttuD_2 | Glycerate 2-kinase. (422 aa) |
| | tktB_2 | Transketolase; Belongs to the transketolase family. (676 aa) |
| | hxlB | 3-hexulose-6-phosphate isomerase. (188 aa) |
| | fitB_2 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (137 aa) |
| | fadA_3 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | glpX | Fructose-1,6-bisphosphatase II / sedoheptulose-1,7-bisphosphatase. (319 aa) |
| | mmsA | Methylmalonate-semialdehyde dehydrogenase [acylating]. (498 aa) |
| | gpgP | Probable phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (200 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (235 aa) |
| | lpd | Dihydrolipoamide dehydrogenase. (464 aa) |
| | SFG76779.1 | Uncharacterized conserved protein, contains ferritin-like DUF455 domain. (269 aa) |
| | acsA_2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa) |
| | fitB_1 | Hypothetical protein. (142 aa) |
| | katE | Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (698 aa) |
| | glyA2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa) |
| | sdaA | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (472 aa) |
| | acnA | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (924 aa) |
| | SFG83887.1 | Hypothetical protein. (140 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (483 aa) |
| | nqo1_2 | NAD-dependent formate dehydrogenase flavoprotein subunit. (568 aa) |
| | SFG37269.1 | Arsenate reductase; Belongs to the ArsC family. (110 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | accB | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa) |
| | dme | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (763 aa) |
| | fabG_3 | 3-oxoacyl-[acyl-carrier-protein] reductase. (241 aa) |
| | cfiB | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (341 aa) |
| | phaJ | 3-hydroxybutyryl-CoA dehydratase. (147 aa) |
| | mmgC_3 | (2S)-methylsuccinyl-CoA dehydrogenase. (564 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (531 aa) |
| | mmgB | 3-hydroxyacyl-CoA dehydrogenase. (292 aa) |
| | SFG41736.1 | Hypothetical protein. (272 aa) |
| | phbA | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | SFG36181.1 | Alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. (410 aa) |
| | flhA_1 | S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (370 aa) |
| | maeB | Allosteric NADP-dependent malic enzyme. (759 aa) |
| | psdht | Threonine dehydratase. (326 aa) |
| | SFG48902.1 | Serine-glyoxylate aminotransferase apoenzyme. (395 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (231 aa) |
| | SFG46358.1 | Aspartate aminotransferase. (376 aa) |
| | ppdK | Pyruvate phosphate dikinase. (856 aa) |
| | kdgK_1 | 2-dehydro-3-deoxygluconokinase. (302 aa) |
| | iolJ | Fructose-bisphosphate aldolase. (271 aa) |
| | gap_1 | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (328 aa) |
| | SFF78345.1 | methylmalonyl-CoA epimerase. (134 aa) |
| | SFF79517.1 | Hypothetical protein. (546 aa) |
| | fgd1 | Probable non-F420 flavinoid oxidoreductase. (323 aa) |
| | sdhB | Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa) |
| | sdhA | Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (603 aa) |
| | SFF80523.1 | Succinate dehydrogenase subunit D. (123 aa) |
| | sdhC | Succinate dehydrogenase subunit C. (127 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (243 aa) |
| | SFF80603.1 | L-erythro-3-methylmalyl-CoA dehydratase. (342 aa) |
| | mcl2 | (3S)-malyl-CoA thioesterase; Belongs to the HpcH/HpaI aldolase family. (285 aa) |
| | mdh | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa) |
| | sucC | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa) |
| | sucA | 2-oxoglutarate dehydrogenase E1 component. (985 aa) |
| | sucB | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (509 aa) |
| | lpd3 | Dihydrolipoamide dehydrogenase. (464 aa) |
| | tdcB_1 | Threonine dehydratase. (322 aa) |
| | tdcB_2 | Threonine dehydratase. (315 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (419 aa) |
| | fadH | 2,4-dienoyl-CoA reductase (NADPH2). (673 aa) |
| | caiD_1 | Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (200 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (262 aa) |
| | fghA | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (268 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (312 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (503 aa) |
| | merA_1 | Dihydrolipoamide dehydrogenase. (469 aa) |
| | lcdH_1 | Carnitine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine. (498 aa) |
| | mmgC_1 | acyl-CoA dehydrogenase. (388 aa) |
| | SFF90101.1 | Acetyl-CoA acetyltransferase. (383 aa) |
| | SFF90144.1 | N-terminal half of MaoC dehydratase. (287 aa) |
| | citE | Citrate lyase subunit beta / citryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (271 aa) |
| | SFF90356.1 | 3-methylfumaryl-CoA hydratase. (275 aa) |
| | ttuE | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | SFF98256.1 | Uncharacterized conserved protein. (137 aa) |
| | arcC2 | Carbamate kinase; Belongs to the carbamate kinase family. (313 aa) |
| | fadA_2 | acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | fadJ_2 | Short chain enoyl-CoA hydratase. (693 aa) |
| | scpA_3 | (R)-ethylmalonyl-CoA mutase. (653 aa) |
| | ccrA2 | crotonyl-CoA carboxylase/reductase. (430 aa) |
