(29 nodes) Mixed, incl. Interleukin-20 family signaling, and Interferon/interleukin receptor domain network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H9G7R1_ANOCA	IL4Ra_N domain-containing protein. (182 aa)
	IL22	Interleukin 22. (182 aa)
	LOC103282032	IRF tryptophan pentad repeat domain-containing protein. (401 aa)
	JAK2	Tyrosine-protein kinase. (1129 aa)
	LOC103278369	Uncharacterized protein. (273 aa)
	SOCS5	Suppressor of cytokine signaling 5. (532 aa)
	LOC103281918	Fibronectin type-III domain-containing protein. (259 aa)
	STAT1	Signal transducer and activator of transcription 1. (1217 aa)
	Il10ra	Fibronectin type-III domain-containing protein. (208 aa)
	IL10	Interleukin 10. (174 aa)
	IL24	Interleukin 24. (178 aa)
	TYK2	Tyrosine-protein kinase. (1186 aa)
	JAK1	Tyrosine-protein kinase. (1158 aa)
	LEPR	Leptin receptor. (840 aa)
	STAT6	Signal transducer and activator of transcription. (677 aa)
	SOCS1	Suppressor of cytokine signaling 1. (193 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (525 aa)
	IL10RB	Interleukin 10 receptor subunit beta. (343 aa)
	SOCS4	Suppressor of cytokine signaling 4. (436 aa)
	SOCS3	Suppressor of cytokine signaling 3. (211 aa)
	STAT3	Signal transducer and activator of transcription. (773 aa)
	LOC100566752	Signal transducer and activator of transcription. (782 aa)
	STAT2	Signal transducer and activator of transcription. (825 aa)
	LOC100560082	SH2 domain-containing protein. (169 aa)
	LOC103282327	IRF-3 domain-containing protein. (182 aa)
	IFNGR1	Interferon gamma receptor 1. (420 aa)
	G1KXN6_ANOCA	Uncharacterized protein. (45 aa)
	LOC103277687	Uncharacterized protein. (178 aa)
	ifnar2	Uncharacterized protein. (554 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1KXN6_ANOCA	IFNAR1	ENSACAP00000020242	ENSACAP00000014482	Uncharacterized protein.	Interferon alpha and beta receptor subunit 1.	0.900
G1KXN6_ANOCA	IFNGR1	ENSACAP00000020242	ENSACAP00000019661	Uncharacterized protein.	Interferon gamma receptor 1.	0.900
G1KXN6_ANOCA	LOC103277687	ENSACAP00000020242	ENSACAP00000020993	Uncharacterized protein.	Uncharacterized protein.	0.900
G1KXN6_ANOCA	LOC103278369	ENSACAP00000020242	ENSACAP00000004088	Uncharacterized protein.	Uncharacterized protein.	0.900
G1KXN6_ANOCA	ifnar2	ENSACAP00000020242	ENSACAP00000022553	Uncharacterized protein.	Uncharacterized protein.	0.900
H9G7R1_ANOCA	IL10	ENSACAP00000003473	ENSACAP00000007764	IL4Ra_N domain-containing protein.	Interleukin 10.	0.447
H9G7R1_ANOCA	Il10ra	ENSACAP00000003473	ENSACAP00000007294	IL4Ra_N domain-containing protein.	Fibronectin type-III domain-containing protein.	0.445
H9G7R1_ANOCA	JAK1	ENSACAP00000003473	ENSACAP00000008587	IL4Ra_N domain-containing protein.	Tyrosine-protein kinase.	0.676
H9G7R1_ANOCA	JAK2	ENSACAP00000003473	ENSACAP00000003850	IL4Ra_N domain-containing protein.	Tyrosine-protein kinase.	0.808
H9G7R1_ANOCA	LOC100560082	ENSACAP00000003473	ENSACAP00000018370	IL4Ra_N domain-containing protein.	SH2 domain-containing protein.	0.415
H9G7R1_ANOCA	LOC100566752	ENSACAP00000003473	ENSACAP00000017675	IL4Ra_N domain-containing protein.	Signal transducer and activator of transcription.	0.522
H9G7R1_ANOCA	SOCS1	ENSACAP00000003473	ENSACAP00000014306	IL4Ra_N domain-containing protein.	Suppressor of cytokine signaling 1.	0.533
H9G7R1_ANOCA	SOCS3	ENSACAP00000003473	ENSACAP00000016418	IL4Ra_N domain-containing protein.	Suppressor of cytokine signaling 3.	0.415
H9G7R1_ANOCA	SOCS4	ENSACAP00000003473	ENSACAP00000016010	IL4Ra_N domain-containing protein.	Suppressor of cytokine signaling 4.	0.530
H9G7R1_ANOCA	SOCS5	ENSACAP00000003473	ENSACAP00000004120	IL4Ra_N domain-containing protein.	Suppressor of cytokine signaling 5.	0.697
H9G7R1_ANOCA	STAT3	ENSACAP00000003473	ENSACAP00000017673	IL4Ra_N domain-containing protein.	Signal transducer and activator of transcription.	0.581
H9G7R1_ANOCA	STAT6	ENSACAP00000003473	ENSACAP00000009595	IL4Ra_N domain-containing protein.	Signal transducer and activator of transcription.	0.522
H9G7R1_ANOCA	TYK2	ENSACAP00000003473	ENSACAP00000008443	IL4Ra_N domain-containing protein.	Tyrosine-protein kinase.	0.676
IFNAR1	G1KXN6_ANOCA	ENSACAP00000014482	ENSACAP00000020242	Interferon alpha and beta receptor subunit 1.	Uncharacterized protein.	0.900
IFNAR1	IFNGR1	ENSACAP00000014482	ENSACAP00000019661	Interferon alpha and beta receptor subunit 1.	Interferon gamma receptor 1.	0.954