(8 nodes) Activation of caspases through apoptosome-mediated cleavage network (Anolis carolinensis)

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Your Input:
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (305 aa)
	LOC100552932	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (258 aa)
	XIAP	X-linked inhibitor of apoptosis. (568 aa)
	birc2	Uncharacterized protein. (603 aa)
	LOC100560655	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1253 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (342 aa)
	LOC100559887	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	CASP7	ENSACAP00000012965	ENSACAP00000009923	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.844
APAF1	CASP9	ENSACAP00000012965	ENSACAP00000015721	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	LOC100552932	ENSACAP00000012965	ENSACAP00000011127	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.930
APAF1	LOC100559887	ENSACAP00000012965	ENSACAP00000022254	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC100560655	ENSACAP00000012965	ENSACAP00000012821	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	XIAP	ENSACAP00000012965	ENSACAP00000011315	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	X-linked inhibitor of apoptosis.	0.876
APAF1	birc2	ENSACAP00000012965	ENSACAP00000012475	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.653
CASP7	APAF1	ENSACAP00000009923	ENSACAP00000012965	Caspase 7; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.844
CASP7	CASP9	ENSACAP00000009923	ENSACAP00000015721	Caspase 7; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.966
CASP7	LOC100552932	ENSACAP00000009923	ENSACAP00000011127	Caspase 7; Belongs to the peptidase C14A family.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.708
CASP7	LOC100559887	ENSACAP00000009923	ENSACAP00000022254	Caspase 7; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.648
CASP7	LOC100560655	ENSACAP00000009923	ENSACAP00000012821	Caspase 7; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.648
CASP7	XIAP	ENSACAP00000009923	ENSACAP00000011315	Caspase 7; Belongs to the peptidase C14A family.	X-linked inhibitor of apoptosis.	0.999
CASP7	birc2	ENSACAP00000009923	ENSACAP00000012475	Caspase 7; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.980
CASP9	APAF1	ENSACAP00000015721	ENSACAP00000012965	Caspase 9; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.999
CASP9	CASP7	ENSACAP00000015721	ENSACAP00000009923	Caspase 9; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.966
CASP9	LOC100552932	ENSACAP00000015721	ENSACAP00000011127	Caspase 9; Belongs to the peptidase C14A family.	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family.	0.934
CASP9	LOC100559887	ENSACAP00000015721	ENSACAP00000022254	Caspase 9; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
CASP9	LOC100560655	ENSACAP00000015721	ENSACAP00000012821	Caspase 9; Belongs to the peptidase C14A family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
CASP9	XIAP	ENSACAP00000015721	ENSACAP00000011315	Caspase 9; Belongs to the peptidase C14A family.	X-linked inhibitor of apoptosis.	0.999