(18 nodes) Amyloid-beta metabolic process, and Amyloidogenic glycoprotein network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H9G3A0_ANOCA	BPTI/Kunitz inhibitor domain-containing protein. (92 aa)
	USP15	Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (1041 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (318 aa)
	APLP2	BPTI/Kunitz inhibitor domain-containing protein. (733 aa)
	H9G777_ANOCA	Uncharacterized protein. (82 aa)
	TTLL6	Tubulin tyrosine ligase like 6. (463 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (454 aa)
	H9GBN3_ANOCA	Uncharacterized protein. (805 aa)
	APH1A	Aph-1 homolog A, gamma-secretase subunit. (265 aa)
	TNFRSF21	TNF receptor superfamily member 21. (639 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	ncstn	Ncstrn_small domain-containing protein. (340 aa)
	psenen	Uncharacterized protein. (101 aa)
	LOC103282942	Uncharacterized protein. (90 aa)
	LOC103282937	Uncharacterized protein. (214 aa)
	H9GQ91_ANOCA	Uncharacterized protein. (134 aa)
	LOC103281949	Uncharacterized protein. (136 aa)
	LOC103282118	Peptidase_M16 domain-containing protein. (238 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH1A	H9GQ91_ANOCA	ENSACAP00000007907	ENSACAP00000018051	Aph-1 homolog A, gamma-secretase subunit.	Uncharacterized protein.	0.904
APH1A	PSEN1	ENSACAP00000007907	ENSACAP00000015950	Aph-1 homolog A, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.980
APH1A	PSEN2	ENSACAP00000007907	ENSACAP00000006363	Aph-1 homolog A, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.978
APH1A	ncstn	ENSACAP00000007907	ENSACAP00000015968	Aph-1 homolog A, gamma-secretase subunit.	Ncstrn_small domain-containing protein.	0.980
APH1A	psenen	ENSACAP00000007907	ENSACAP00000016385	Aph-1 homolog A, gamma-secretase subunit.	Uncharacterized protein.	0.990
APLP2	BACE1	ENSACAP00000003110	ENSACAP00000001380	BPTI/Kunitz inhibitor domain-containing protein.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.476
APLP2	H9GBN3_ANOCA	ENSACAP00000003110	ENSACAP00000006456	BPTI/Kunitz inhibitor domain-containing protein.	Uncharacterized protein.	0.537
APLP2	H9GQ91_ANOCA	ENSACAP00000003110	ENSACAP00000018051	BPTI/Kunitz inhibitor domain-containing protein.	Uncharacterized protein.	0.548
APLP2	LOC103282118	ENSACAP00000003110	ENSACAP00000019877	BPTI/Kunitz inhibitor domain-containing protein.	Peptidase_M16 domain-containing protein.	0.537
APLP2	PSEN1	ENSACAP00000003110	ENSACAP00000015950	BPTI/Kunitz inhibitor domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.535
APLP2	PSEN2	ENSACAP00000003110	ENSACAP00000006363	BPTI/Kunitz inhibitor domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.549
APLP2	TNFRSF21	ENSACAP00000003110	ENSACAP00000013161	BPTI/Kunitz inhibitor domain-containing protein.	TNF receptor superfamily member 21.	0.605
APLP2	ncstn	ENSACAP00000003110	ENSACAP00000015968	BPTI/Kunitz inhibitor domain-containing protein.	Ncstrn_small domain-containing protein.	0.632
APLP2	psenen	ENSACAP00000003110	ENSACAP00000016385	BPTI/Kunitz inhibitor domain-containing protein.	Uncharacterized protein.	0.495
BACE1	APLP2	ENSACAP00000001380	ENSACAP00000003110	Beta-secretase 1; Belongs to the peptidase A1 family.	BPTI/Kunitz inhibitor domain-containing protein.	0.476
BACE1	H9G777_ANOCA	ENSACAP00000001380	ENSACAP00000003128	Beta-secretase 1; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.476
BACE1	LOC103282937	ENSACAP00000001380	ENSACAP00000017699	Beta-secretase 1; Belongs to the peptidase A1 family.	Uncharacterized protein.	0.661
BACE1	ncstn	ENSACAP00000001380	ENSACAP00000015968	Beta-secretase 1; Belongs to the peptidase A1 family.	Ncstrn_small domain-containing protein.	0.552
H9G3A0_ANOCA	TNFRSF21	ENSACAP00000000107	ENSACAP00000013161	BPTI/Kunitz inhibitor domain-containing protein.	TNF receptor superfamily member 21.	0.408
H9G777_ANOCA	BACE1	ENSACAP00000003128	ENSACAP00000001380	Uncharacterized protein.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.476