STRINGSTRING
RAD52 RAD52 RMI1 RMI1 TOP3B TOP3B LOC100556408 LOC100556408 WRN WRN EXO1 EXO1 brca2 brca2 TDRD3 TDRD3 atm atm RAD51B RAD51B MEIOB MEIOB H9GC47_ANOCA H9GC47_ANOCA RBBP8 RBBP8 DMC1 DMC1 TOP3A TOP3A DNA2 DNA2 NBN NBN XRCC2 XRCC2 RECQL4 RECQL4 XRCC3 XRCC3 RAD51C RAD51C palb2 palb2 rad50 rad50 RPA3 RPA3 brca1 brca1 RAD51 RAD51 MRE11 MRE11 BLM BLM RPA1 RPA1 BARD1 BARD1 rmi2 rmi2 RPA2 RPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD52RAD52 homolog, DNA repair protein. (204 aa)
RMI1RecQ mediated genome instability 1. (569 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
LOC100556408FAT domain-containing protein. (2448 aa)
WRNWRN RecQ like helicase. (1315 aa)
EXO1Exonuclease 1. (810 aa)
brca2Tower domain-containing protein. (1241 aa)
TDRD3Tudor domain containing 3. (735 aa)
atmUncharacterized protein; Belongs to the PI3/PI4-kinase family. (423 aa)
RAD51BRAD51 paralog B. (418 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
H9GC47_ANOCABeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (132 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (345 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (997 aa)
DNA2DNA replication helicase/nuclease 2. (1065 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (761 aa)
XRCC2X-ray repair cross complementing 2. (301 aa)
RECQL4RecQ like helicase 4. (1239 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (375 aa)
RAD51CRAD51 paralog C. (188 aa)
palb2PALB2_WD40 domain-containing protein. (343 aa)
rad50Zinc-hook domain-containing protein. (1312 aa)
RPA3Replication protein A3. (121 aa)
brca1Uncharacterized protein. (772 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa)
BLMBLM RecQ like helicase. (1396 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
BARD1BRCA1 associated RING domain 1. (769 aa)
rmi2Uncharacterized protein. (153 aa)
RPA2Replication protein A2. (268 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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