(10 nodes) RecQ family helicase-topoisomerase III complex, and DNA replication factor A complex network (Anolis carolinensis)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	RAD52	RAD52 homolog, DNA repair protein. (204 aa)
	RMI1	RecQ mediated genome instability 1. (569 aa)
	WRN	WRN RecQ like helicase. (1315 aa)
	H9GC47_ANOCA	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (132 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (997 aa)
	RPA3	Replication protein A3. (121 aa)
	BLM	BLM RecQ like helicase. (1396 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	rmi2	Uncharacterized protein. (153 aa)
	RPA2	Replication protein A2. (268 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	H9GC47_ANOCA	ENSACAP00000014045	ENSACAP00000006805	BLM RecQ like helicase.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.756
BLM	RAD52	ENSACAP00000014045	ENSACAP00000000025	BLM RecQ like helicase.	RAD52 homolog, DNA repair protein.	0.931
BLM	RMI1	ENSACAP00000014045	ENSACAP00000001366	BLM RecQ like helicase.	RecQ mediated genome instability 1.	0.998
BLM	RPA1	ENSACAP00000014045	ENSACAP00000014346	BLM RecQ like helicase.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.998
BLM	RPA2	ENSACAP00000014045	ENSACAP00000017385	BLM RecQ like helicase.	Replication protein A2.	0.974
BLM	RPA3	ENSACAP00000014045	ENSACAP00000012819	BLM RecQ like helicase.	Replication protein A3.	0.997
BLM	TOP3A	ENSACAP00000014045	ENSACAP00000009102	BLM RecQ like helicase.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.999
BLM	WRN	ENSACAP00000014045	ENSACAP00000003095	BLM RecQ like helicase.	WRN RecQ like helicase.	0.684
BLM	rmi2	ENSACAP00000014045	ENSACAP00000015697	BLM RecQ like helicase.	Uncharacterized protein.	0.988
H9GC47_ANOCA	BLM	ENSACAP00000006805	ENSACAP00000014045	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	BLM RecQ like helicase.	0.756
H9GC47_ANOCA	RAD52	ENSACAP00000006805	ENSACAP00000000025	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RAD52 homolog, DNA repair protein.	0.886
H9GC47_ANOCA	RMI1	ENSACAP00000006805	ENSACAP00000001366	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RecQ mediated genome instability 1.	0.721
H9GC47_ANOCA	RPA1	ENSACAP00000006805	ENSACAP00000014346	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.945
H9GC47_ANOCA	RPA3	ENSACAP00000006805	ENSACAP00000012819	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A3.	0.929
H9GC47_ANOCA	TOP3A	ENSACAP00000006805	ENSACAP00000009102	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.728
H9GC47_ANOCA	WRN	ENSACAP00000006805	ENSACAP00000003095	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	WRN RecQ like helicase.	0.977
RAD52	BLM	ENSACAP00000000025	ENSACAP00000014045	RAD52 homolog, DNA repair protein.	BLM RecQ like helicase.	0.931
RAD52	H9GC47_ANOCA	ENSACAP00000000025	ENSACAP00000006805	RAD52 homolog, DNA repair protein.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.886
RAD52	RMI1	ENSACAP00000000025	ENSACAP00000001366	RAD52 homolog, DNA repair protein.	RecQ mediated genome instability 1.	0.794
RAD52	RPA1	ENSACAP00000000025	ENSACAP00000014346	RAD52 homolog, DNA repair protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.998