(24 nodes) Detoxification of Reactive Oxygen Species, and Protein repair network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (241 aa)
	txnip	Arrestin_N domain-containing protein. (124 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (137 aa)
	HAO1	Hydroxyacid oxidase 1. (370 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	MSRB3	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (184 aa)
	sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
	prdx5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (206 aa)
	PRDX4	Peroxiredoxin 4. (273 aa)
	HAO2	Hydroxyacid oxidase 2. (378 aa)
	ERP44	Endoplasmic reticulum protein 44. (392 aa)
	msra	PMSR domain-containing protein. (235 aa)
	GLRX	Glutaredoxin. (105 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	H9GJN5_ANOCA	Catalase domain-containing protein. (348 aa)
	LOC100566382	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	PGP	Phosphoglycolate phosphatase. (330 aa)
	PRDX1	Peroxiredoxin 1. (199 aa)
	TXN2	Thioredoxin 2. (171 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	G1KUA1_ANOCA	NDK domain-containing protein; Belongs to the NDK family. (119 aa)
	LOC100564467	Catalase domain-containing protein. (365 aa)
	msrb2	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (193 aa)
	TXNDC8	Thioredoxin; Belongs to the thioredoxin family. (123 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERP44	PRDX1	ENSACAP00000008776	ENSACAP00000014849	Endoplasmic reticulum protein 44.	Peroxiredoxin 1.	0.595
ERP44	PRDX2	ENSACAP00000008776	ENSACAP00000003309	Endoplasmic reticulum protein 44.	Peroxiredoxin 2.	0.595
ERP44	PRDX4	ENSACAP00000008776	ENSACAP00000007342	Endoplasmic reticulum protein 44.	Peroxiredoxin 4.	0.886
ERP44	TXN	ENSACAP00000008776	ENSACAP00000012786	Endoplasmic reticulum protein 44.	Thioredoxin; Belongs to the thioredoxin family.	0.430
ERP44	msra	ENSACAP00000008776	ENSACAP00000009872	Endoplasmic reticulum protein 44.	PMSR domain-containing protein.	0.624
ERP44	prdx5	ENSACAP00000008776	ENSACAP00000006272	Endoplasmic reticulum protein 44.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.543
G1KUA1_ANOCA	GLRX	ENSACAP00000017404	ENSACAP00000012683	NDK domain-containing protein; Belongs to the NDK family.	Glutaredoxin.	0.677
G1KUA1_ANOCA	H9GJN5_ANOCA	ENSACAP00000017404	ENSACAP00000012904	NDK domain-containing protein; Belongs to the NDK family.	Catalase domain-containing protein.	0.550
G1KUA1_ANOCA	LOC100564467	ENSACAP00000017404	ENSACAP00000023066	NDK domain-containing protein; Belongs to the NDK family.	Catalase domain-containing protein.	0.550
G1KUA1_ANOCA	LOC100566382	ENSACAP00000017404	ENSACAP00000013065	NDK domain-containing protein; Belongs to the NDK family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.550
G1KUA1_ANOCA	MSRB3	ENSACAP00000017404	ENSACAP00000003388	NDK domain-containing protein; Belongs to the NDK family.	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.	0.580
G1KUA1_ANOCA	PRDX1	ENSACAP00000017404	ENSACAP00000014849	NDK domain-containing protein; Belongs to the NDK family.	Peroxiredoxin 1.	0.837
G1KUA1_ANOCA	PRDX2	ENSACAP00000017404	ENSACAP00000003309	NDK domain-containing protein; Belongs to the NDK family.	Peroxiredoxin 2.	0.837
G1KUA1_ANOCA	PRDX4	ENSACAP00000017404	ENSACAP00000007342	NDK domain-containing protein; Belongs to the NDK family.	Peroxiredoxin 4.	0.837
G1KUA1_ANOCA	SOD1	ENSACAP00000017404	ENSACAP00000002450	NDK domain-containing protein; Belongs to the NDK family.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.726
G1KUA1_ANOCA	SOD3	ENSACAP00000017404	ENSACAP00000000349	NDK domain-containing protein; Belongs to the NDK family.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.726
G1KUA1_ANOCA	TXN2	ENSACAP00000017404	ENSACAP00000016094	NDK domain-containing protein; Belongs to the NDK family.	Thioredoxin 2.	0.757
G1KUA1_ANOCA	msra	ENSACAP00000017404	ENSACAP00000009872	NDK domain-containing protein; Belongs to the NDK family.	PMSR domain-containing protein.	0.940
G1KUA1_ANOCA	msrb2	ENSACAP00000017404	ENSACAP00000023195	NDK domain-containing protein; Belongs to the NDK family.	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.	0.580
G1KUA1_ANOCA	prdx5	ENSACAP00000017404	ENSACAP00000006272	NDK domain-containing protein; Belongs to the NDK family.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.961