(11 nodes) SUMOylation of intracellular receptors, and SUMO activating enzyme complex network (Anolis carolinensis)

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Your Input:
	UBA2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (695 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	SAE1	SUMO1 activating enzyme subunit 1. (355 aa)
	RANGAP1	Ran GTPase activating protein 1. (591 aa)
	SUMO1	Small ubiquitin-related modifier. (101 aa)
	KCTD2	Potassium channel tetramerization domain containing 2. (241 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	SUMO3	Small ubiquitin-related modifier. (94 aa)
	PIAS1	Protein inhibitor of activated STAT 1. (661 aa)
	PIAS2	Protein inhibitor of activated STAT 2. (601 aa)
	PIAS3	Protein inhibitor of activated STAT 3. (703 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCTD2	PIAS1	ENSACAP00000005989	ENSACAP00000010047	Potassium channel tetramerization domain containing 2.	Protein inhibitor of activated STAT 1.	0.766
KCTD2	PIAS2	ENSACAP00000005989	ENSACAP00000012012	Potassium channel tetramerization domain containing 2.	Protein inhibitor of activated STAT 2.	0.766
KCTD2	PIAS3	ENSACAP00000005989	ENSACAP00000013643	Potassium channel tetramerization domain containing 2.	Protein inhibitor of activated STAT 3.	0.766
KCTD2	RANGAP1	ENSACAP00000005989	ENSACAP00000004899	Potassium channel tetramerization domain containing 2.	Ran GTPase activating protein 1.	0.958
KCTD2	SAE1	ENSACAP00000005989	ENSACAP00000003938	Potassium channel tetramerization domain containing 2.	SUMO1 activating enzyme subunit 1.	0.957
KCTD2	SUMO1	ENSACAP00000005989	ENSACAP00000005060	Potassium channel tetramerization domain containing 2.	Small ubiquitin-related modifier.	0.960
KCTD2	SUMO3	ENSACAP00000005989	ENSACAP00000008101	Potassium channel tetramerization domain containing 2.	Small ubiquitin-related modifier.	0.913
KCTD2	UBA2	ENSACAP00000005989	ENSACAP00000001485	Potassium channel tetramerization domain containing 2.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.964
KCTD2	sumo2	ENSACAP00000005989	ENSACAP00000006073	Potassium channel tetramerization domain containing 2.	Small ubiquitin-related modifier.	0.913
PIAS1	KCTD2	ENSACAP00000010047	ENSACAP00000005989	Protein inhibitor of activated STAT 1.	Potassium channel tetramerization domain containing 2.	0.766
PIAS1	PIAS2	ENSACAP00000010047	ENSACAP00000012012	Protein inhibitor of activated STAT 1.	Protein inhibitor of activated STAT 2.	0.916
PIAS1	PIAS3	ENSACAP00000010047	ENSACAP00000013643	Protein inhibitor of activated STAT 1.	Protein inhibitor of activated STAT 3.	0.902
PIAS1	SAE1	ENSACAP00000010047	ENSACAP00000003938	Protein inhibitor of activated STAT 1.	SUMO1 activating enzyme subunit 1.	0.407
PIAS1	SUMO1	ENSACAP00000010047	ENSACAP00000005060	Protein inhibitor of activated STAT 1.	Small ubiquitin-related modifier.	0.924
PIAS1	SUMO3	ENSACAP00000010047	ENSACAP00000008101	Protein inhibitor of activated STAT 1.	Small ubiquitin-related modifier.	0.852
PIAS1	UBA2	ENSACAP00000010047	ENSACAP00000001485	Protein inhibitor of activated STAT 1.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.407
PIAS1	UBE2I	ENSACAP00000010047	ENSACAP00000003329	Protein inhibitor of activated STAT 1.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.817
PIAS1	sumo2	ENSACAP00000010047	ENSACAP00000006073	Protein inhibitor of activated STAT 1.	Small ubiquitin-related modifier.	0.852
PIAS2	KCTD2	ENSACAP00000012012	ENSACAP00000005989	Protein inhibitor of activated STAT 2.	Potassium channel tetramerization domain containing 2.	0.766
PIAS2	PIAS1	ENSACAP00000012012	ENSACAP00000010047	Protein inhibitor of activated STAT 2.	Protein inhibitor of activated STAT 1.	0.916