STRINGSTRING
BRCC3 BRCC3 RNF8 RNF8 LOC103282074 LOC103282074 UIMC1 UIMC1 G1KE84_ANOCA G1KE84_ANOCA NSD2 NSD2 BABAM2 BABAM2 ABRAXAS1 ABRAXAS1 RNF169 RNF169 ABRAXAS2 ABRAXAS2 HERC1 HERC1 RNF168 RNF168 ankrd11 ankrd11 G1KVT4_ANOCA G1KVT4_ANOCA RIF1 RIF1 H9GVW7_ANOCA H9GVW7_ANOCA LOC103280590 LOC103280590 R4GAZ5_ANOCA R4GAZ5_ANOCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCC3BRCA1/BRCA2-containing complex subunit 3. (261 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
LOC10328207453-BP1_Tudor domain-containing protein. (1012 aa)
UIMC1Ubiquitin interaction motif containing 1. (714 aa)
G1KE84_ANOCAPWWP domain-containing protein. (102 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1217 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (404 aa)
RNF169Ring finger protein 169. (592 aa)
ABRAXAS2Abraxas 2, BRISC complex subunit. (416 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4934 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (577 aa)
ankrd11ANK_REP_REGION domain-containing protein. (2710 aa)
G1KVT4_ANOCAReverse transcriptase domain-containing protein. (399 aa)
RIF1Replication timing regulatory factor 1. (2361 aa)
H9GVW7_ANOCAReverse transcriptase domain-containing protein. (356 aa)
LOC103280590Uncharacterized protein. (1496 aa)
R4GAZ5_ANOCAReverse transcriptase domain-containing protein. (767 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.