(14 nodes) Telomere maintenance via recombination network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ercc1	Uncharacterized protein. (297 aa)
	RAD51C	RAD51 paralog C. (188 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	H9GT41_ANOCA	Uncharacterized protein. (189 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (842 aa)
	SMC5	Structural maintenance of chromosomes 5. (1079 aa)
	TEP1	Telomerase associated protein 1. (2566 aa)
	SMC6	Structural maintenance of chromosomes 6. (1117 aa)
	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (239 aa)
	XRCC3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (375 aa)
	rad50	Zinc-hook domain-containing protein. (1312 aa)
	TPRKB	TP53RK binding protein; Belongs to the CGI121/TPRKB family. (176 aa)
	brca2	Tower domain-containing protein. (1241 aa)
	xrcc1	Uncharacterized protein. (656 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERCC4	H9GT41_ANOCA	ENSACAP00000003517	ENSACAP00000019842	ERCC excision repair 4, endonuclease catalytic subunit.	Uncharacterized protein.	0.967
ERCC4	RAD51	ENSACAP00000003517	ENSACAP00000013598	ERCC excision repair 4, endonuclease catalytic subunit.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.914
ERCC4	RAD51C	ENSACAP00000003517	ENSACAP00000010810	ERCC excision repair 4, endonuclease catalytic subunit.	RAD51 paralog C.	0.730
ERCC4	SMC5	ENSACAP00000003517	ENSACAP00000000826	ERCC excision repair 4, endonuclease catalytic subunit.	Structural maintenance of chromosomes 5.	0.404
ERCC4	XRCC3	ENSACAP00000003517	ENSACAP00000010557	ERCC excision repair 4, endonuclease catalytic subunit.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.771
ERCC4	brca2	ENSACAP00000003517	ENSACAP00000004459	ERCC excision repair 4, endonuclease catalytic subunit.	Tower domain-containing protein.	0.629
ERCC4	ercc1	ENSACAP00000003517	ENSACAP00000023179	ERCC excision repair 4, endonuclease catalytic subunit.	Uncharacterized protein.	0.980
ERCC4	rad50	ENSACAP00000003517	ENSACAP00000012528	ERCC excision repair 4, endonuclease catalytic subunit.	Zinc-hook domain-containing protein.	0.647
ERCC4	xrcc1	ENSACAP00000003517	ENSACAP00000004173	ERCC excision repair 4, endonuclease catalytic subunit.	Uncharacterized protein.	0.602
H9GT41_ANOCA	ERCC4	ENSACAP00000019842	ENSACAP00000003517	Uncharacterized protein.	ERCC excision repair 4, endonuclease catalytic subunit.	0.967
H9GT41_ANOCA	RAD51	ENSACAP00000019842	ENSACAP00000013598	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.576
H9GT41_ANOCA	RAD51C	ENSACAP00000019842	ENSACAP00000010810	Uncharacterized protein.	RAD51 paralog C.	0.417
H9GT41_ANOCA	XRCC3	ENSACAP00000019842	ENSACAP00000010557	Uncharacterized protein.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.489
H9GT41_ANOCA	brca2	ENSACAP00000019842	ENSACAP00000004459	Uncharacterized protein.	Tower domain-containing protein.	0.435
H9GT41_ANOCA	rad50	ENSACAP00000019842	ENSACAP00000012528	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.444
H9GT41_ANOCA	xrcc1	ENSACAP00000019842	ENSACAP00000004173	Uncharacterized protein.	Uncharacterized protein.	0.471
NSMCE2	RAD51	ENSACAP00000010131	ENSACAP00000013598	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.683
NSMCE2	SMC5	ENSACAP00000010131	ENSACAP00000000826	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	Structural maintenance of chromosomes 5.	0.999
NSMCE2	SMC6	ENSACAP00000010131	ENSACAP00000001628	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	Structural maintenance of chromosomes 6.	0.999
NSMCE2	XRCC3	ENSACAP00000010131	ENSACAP00000010557	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.438