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RAD51 RAD51 rad50 rad50 RUVBL2 RUVBL2 Slx4 Slx4 PRKDC PRKDC ACTR8 ACTR8 PARP3 PARP3 H9GHQ1_ANOCA H9GHQ1_ANOCA RAD51C RAD51C XRCC3 XRCC3 RECQL4 RECQL4 FBXO4 FBXO4 NBN NBN mcrs1 mcrs1 NSMCE2 NSMCE2 INO80E INO80E GAR1 GAR1 XRCC5 XRCC5 PTGES3 PTGES3 UCHL5 UCHL5 TEP1 TEP1 hus1 hus1 APEX1 APEX1 TPRKB TPRKB H9GCY1_ANOCA H9GCY1_ANOCA RUVBL1 RUVBL1 ZBTB48 ZBTB48 atm atm STN1 STN1 ATR ATR XRCC6 XRCC6 brca2 brca2 xrcc1 xrcc1 INO80D INO80D Tinf2 Tinf2 CCNE2 CCNE2 INO80 INO80 ERCC4 ERCC4 TERF2 TERF2 WRAP53 WRAP53 WRN WRN LOC100556408 LOC100556408 LOC100554464 LOC100554464 DCLRE1B DCLRE1B SMC6 SMC6 TERT TERT DCLRE1C DCLRE1C PCNA PCNA SMC5 SMC5 POT1 POT1 ercc1 ercc1 PINX1 PINX1 RIF1 RIF1 DCLRE1A DCLRE1A H9GT41_ANOCA H9GT41_ANOCA ZNF827 ZNF827 NOP10 NOP10 NFRKB NFRKB TFPT TFPT LTO1 LTO1 DKC1 DKC1 slx1a slx1a CCNE1 CCNE1 TELO2 TELO2 RPA1 RPA1 BLM BLM MRE11 MRE11 PIF1 PIF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
rad50Zinc-hook domain-containing protein. (1312 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (462 aa)
Slx4Uncharacterized protein. (81 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4100 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (641 aa)
PARP3Poly [ADP-ribose] polymerase. (542 aa)
H9GHQ1_ANOCAUncharacterized protein. (755 aa)
RAD51CRAD51 paralog C. (188 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (375 aa)
RECQL4RecQ like helicase 4. (1239 aa)
FBXO4F-box protein 4. (390 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (761 aa)
mcrs1FHA domain-containing protein. (449 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (239 aa)
INO80EINO80 complex subunit E. (253 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (213 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (729 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (331 aa)
TEP1Telomerase associated protein 1. (2566 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (317 aa)
TPRKBTP53RK binding protein; Belongs to the CGI121/TPRKB family. (176 aa)
H9GCY1_ANOCARap1_C domain-containing protein. (116 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
ZBTB48Zinc finger and BTB domain containing 48. (281 aa)
atmUncharacterized protein; Belongs to the PI3/PI4-kinase family. (423 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (361 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa)
XRCC6X-ray repair cross complementing 6. (614 aa)
brca2Tower domain-containing protein. (1241 aa)
xrcc1Uncharacterized protein. (656 aa)
INO80DINO80 complex subunit D. (1042 aa)
Tinf2TINF2_N domain-containing protein. (223 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (397 aa)
INO80INO80 complex ATPase subunit. (1421 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (842 aa)
TERF2Telomeric repeat binding factor 2. (696 aa)
WRAP53WD repeat containing antisense to TP53. (383 aa)
WRNWRN RecQ like helicase. (1315 aa)
LOC100556408FAT domain-containing protein. (2448 aa)
LOC100554464FHA domain-containing protein. (118 aa)
DCLRE1BDNA cross-link repair 1B. (309 aa)
SMC6Structural maintenance of chromosomes 6. (1117 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1334 aa)
DCLRE1CDNA cross-link repair 1C. (592 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SMC5Structural maintenance of chromosomes 5. (1079 aa)
POT1Protection of telomeres 1. (774 aa)
ercc1Uncharacterized protein. (297 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (344 aa)
RIF1Replication timing regulatory factor 1. (2361 aa)
DCLRE1ADNA cross-link repair 1A. (998 aa)
H9GT41_ANOCAUncharacterized protein. (189 aa)
ZNF827Zinc finger protein 827. (763 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
NFRKBNuclear factor related to kappaB binding protein. (1335 aa)
TFPTTCF3 fusion partner. (245 aa)
LTO1LTO1 maturation factor of ABCE1. (140 aa)
DKC1Dyskerin pseudouridine synthase 1. (579 aa)
slx1aStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (268 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (398 aa)
TELO2Telomere maintenance 2. (690 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
BLMBLM RecQ like helicase. (1396 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (640 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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