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MCM5 MCM5 rmi2 rmi2 slx1a slx1a G1KQ62_ANOCA G1KQ62_ANOCA RPA1 RPA1 BLM BLM MRE11 MRE11 RAD51 RAD51 brca1 brca1 RPA3 RPA3 Slx4 Slx4 NUCKS1 NUCKS1 MCM7 MCM7 MCM4 MCM4 palb2 palb2 SPIDR SPIDR PSMD14 PSMD14 POLL POLL REV3L REV3L LOC103282856 LOC103282856 RAD21 RAD21 RAD51C RAD51C XRCC3 XRCC3 RECQL4 RECQL4 FANCB FANCB XRCC2 XRCC2 MMS22L MMS22L NBN NBN NSMCE2 NSMCE2 WDR48 WDR48 NIPBL NIPBL TOP3A TOP3A DMC1 DMC1 hus1 hus1 RBBP8 RBBP8 TONSL TONSL MCM2 MCM2 Swi5 Swi5 SAMHD1 SAMHD1 EPC1 EPC1 RECQL5 RECQL5 RAD54L RAD54L MBTD1 MBTD1 FBH1 FBH1 LOC100556408 LOC100556408 WRN WRN NSMCE1 NSMCE1 ERCC4 ERCC4 INO80 INO80 rad54b rad54b LOC103282328 LOC103282328 FANCM FANCM xrcc1 xrcc1 brca2 brca2 MCM3 MCM3 atm atm EXD2 EXD2 GINS2 GINS2 SMC6 SMC6 GEN1 GEN1 CDC7 CDC7 RMI1 RMI1 MCM6 MCM6 SMC5 SMC5 CDC45 CDC45 mcm8 mcm8 GINS4 GINS4 tm4sf19 tm4sf19 RAD52 RAD52 AP5S1 AP5S1 FAN1 FAN1 LOC103282889 LOC103282889 ankle1 ankle1 NABP2 NABP2 LOC103282695 LOC103282695 RAD21L1 RAD21L1 HELQ HELQ rec8 rec8 G1KV58_ANOCA G1KV58_ANOCA RNF138 RNF138 MCM9 MCM9 AP5Z1 AP5Z1 RECQL RECQL Ccdc155 Ccdc155 INIP INIP SWSAP1 SWSAP1 RAD51B RAD51B ZFYVE26 ZFYVE26 MEIOB MEIOB RFWD3 RFWD3 nabp1 nabp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM5DNA helicase; Belongs to the MCM family. (733 aa)
rmi2Uncharacterized protein. (153 aa)
slx1aStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (268 aa)
G1KQ62_ANOCAUncharacterized protein. (70 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
BLMBLM RecQ like helicase. (1396 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
brca1Uncharacterized protein. (772 aa)
RPA3Replication protein A3. (121 aa)
Slx4Uncharacterized protein. (81 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (294 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa)
MCM4DNA helicase; Belongs to the MCM family. (867 aa)
palb2PALB2_WD40 domain-containing protein. (343 aa)
SPIDRScaffold protein involved in DNA repair. (990 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
POLLDNA polymerase lambda; Belongs to the DNA polymerase type-X family. (574 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3091 aa)
LOC103282856Uncharacterized protein. (158 aa)
RAD21RAD21 cohesin complex component. (627 aa)
RAD51CRAD51 paralog C. (188 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (375 aa)
RECQL4RecQ like helicase 4. (1239 aa)
FANCBFA complementation group B. (836 aa)
XRCC2X-ray repair cross complementing 2. (301 aa)
MMS22LMMS22 like, DNA repair protein. (1249 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (761 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (239 aa)
WDR48WD repeat domain 48. (692 aa)
NIPBLNipped-B protein. (2777 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (997 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (345 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
TONSLTonsoku like, DNA repair protein. (1236 aa)
MCM2DNA helicase; Belongs to the MCM family. (888 aa)
Swi5Uncharacterized protein. (74 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (668 aa)
EPC1Enhancer of polycomb homolog. (742 aa)
RECQL5RecQ like helicase 5. (1015 aa)
RAD54LRAD54 like. (744 aa)
MBTD1Mbt domain containing 1. (622 aa)
FBH1F-box DNA helicase 1. (1043 aa)
LOC100556408FAT domain-containing protein. (2448 aa)
WRNWRN RecQ like helicase. (1315 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (232 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (842 aa)
INO80INO80 complex ATPase subunit. (1421 aa)
rad54bUncharacterized protein. (798 aa)
LOC103282328Rad21_Rec8_N domain-containing protein. (256 aa)
FANCMFA complementation group M. (1855 aa)
xrcc1Uncharacterized protein. (656 aa)
brca2Tower domain-containing protein. (1241 aa)
MCM3DNA helicase; Belongs to the MCM family. (813 aa)
atmUncharacterized protein; Belongs to the PI3/PI4-kinase family. (423 aa)
EXD2Exonuclease 3'-5' domain containing 2. (619 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
SMC6Structural maintenance of chromosomes 6. (1117 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (933 aa)
CDC7Cell division cycle 7. (561 aa)
RMI1RecQ mediated genome instability 1. (569 aa)
MCM6DNA helicase; Belongs to the MCM family. (814 aa)
SMC5Structural maintenance of chromosomes 5. (1079 aa)
CDC45Cell division cycle 45. (566 aa)
mcm8MCM domain-containing protein; Belongs to the MCM family. (830 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
tm4sf19Uncharacterized protein. (201 aa)
RAD52RAD52 homolog, DNA repair protein. (204 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (237 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1019 aa)
LOC103282889PALB2_WD40 domain-containing protein. (186 aa)
ankle1Uncharacterized protein. (470 aa)
NABP2Nucleic acid binding protein 2. (215 aa)
LOC103282695SOSS complex subunit B2. (111 aa)
RAD21L1RAD21 cohesin complex component like 1. (625 aa)
HELQHelicase, POLQ like. (1045 aa)
rec8Rad21_Rec8 domain-containing protein. (295 aa)
G1KV58_ANOCARQC domain-containing protein. (207 aa)
RNF138Ring finger protein 138. (288 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1184 aa)
AP5Z1Adaptor related protein complex 5 subunit zeta 1. (813 aa)
RECQLRecQ like helicase. (452 aa)
Ccdc155Uncharacterized protein. (330 aa)
INIPINTS3 and NABP interacting protein. (124 aa)
SWSAP1SWIM-type zinc finger 7 associated protein 1. (255 aa)
RAD51BRAD51 paralog B. (418 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2582 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
RFWD3Ring finger and WD repeat domain 3. (701 aa)
nabp1OB domain-containing protein. (212 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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