(130 nodes) Ras protein signal transduction network (Anolis carolinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDC42EP4	CDC42 effector protein 4. (341 aa)
	LOC100560886	Uncharacterized protein. (108 aa)
	KSR1	Kinase suppressor of ras 1. (600 aa)
	H9GU47_ANOCA	Uncharacterized protein. (73 aa)
	C15orf62	Chromosome 15 open reading frame 62. (187 aa)
	LOC100563415	CRIB domain-containing protein. (228 aa)
	myo9b	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (800 aa)
	CDC42EP2	CDC42 effector protein 2. (67 aa)
	RERG	RAS like estrogen regulated growth inhibitor. (180 aa)
	LOC103282543	Uncharacterized protein. (158 aa)
	rap1a	Uncharacterized protein. (184 aa)
	RALGPS1	Ral GEF with PH domain and SH3 binding motif 1. (582 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	LOC100564889	EF-hand domain-containing protein. (93 aa)
	LOC100563825	BZIP domain-containing protein. (341 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1412 aa)
	RAB4A	RAB4A, member RAS oncogene family. (230 aa)
	RAP2A	RAP2A, member of RAS oncogene family. (183 aa)
	RIPOR1	RHO family interacting cell polarization regulator 1. (1150 aa)
	KIAA0355	KIAA0355. (473 aa)
	RAB30	RAB30, member RAS oncogene family. (203 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1064 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1282 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	RAB33B	RAB33B, member RAS oncogene family. (225 aa)
	RASGRP4	RAS guanyl releasing protein 4. (631 aa)
	BRAP	BRCA1 associated protein. (572 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (491 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1505 aa)
	RHOU	Ras homolog family member U. (290 aa)
	NRAS	NRAS proto-oncogene, GTPase. (194 aa)
	CSDE1	Cold shock domain containing E1. (796 aa)
	RAB12	RAB12, member RAS oncogene family. (258 aa)
	RHOV	Ras homolog family member V. (165 aa)
	RB1	RB transcriptional corepressor 1. (901 aa)
	rgl2	Uncharacterized protein. (591 aa)
	RAB35	RAB35, member RAS oncogene family. (201 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	USP50	Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (378 aa)
	RALB	RAS like proto-oncogene B. (206 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1568 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1078 aa)
	RASGEF1A	RasGEF domain family member 1A. (497 aa)
	NGFR	Nerve growth factor receptor. (446 aa)
	synj2bp	PDZ domain-containing protein. (145 aa)
	SGSM3	Small G protein signaling modulator 3. (752 aa)
	itga3	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1053 aa)
	DOK3	Docking protein 3. (440 aa)
	GPSM2	G protein signaling modulator 2. (659 aa)
	RAB39A	RAB39A, member RAS oncogene family. (228 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (817 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1340 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	NISCH	Nischarin. (1456 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (314 aa)
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	TMEM19	Transmembrane protein 19. (413 aa)
	RAB21	RAB21, member RAS oncogene family. (245 aa)
	PLCE1	Phospholipase C epsilon 1. (2166 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1357 aa)
	CDC42EP3	CDC42 effector protein 3. (257 aa)
	GNA12	G protein subunit alpha 12. (378 aa)
	RASSF1	Ras association domain family member 1. (273 aa)
	RAB33A	RAB33A, member RAS oncogene family. (218 aa)
	H9GEJ9_ANOCA	Uncharacterized protein. (199 aa)
	H9GEL4_ANOCA	Ras-GAP domain-containing protein. (53 aa)
	LOC103280911	Uncharacterized protein. (237 aa)
	LOC103282177	Uncharacterized protein. (180 aa)
	DOK1	Docking protein 1. (282 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (473 aa)
	RASGRP3	RAS guanyl releasing protein 3. (615 aa)
	SHTN1	Shootin 1. (650 aa)
	RASGEF1B	RasGEF domain family member 1B. (532 aa)
	LOC100559953	Uncharacterized protein. (186 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (204 aa)
	WASF1	WASP family member 1. (548 aa)
	ARHGDIB	Rho GDP dissociation inhibitor beta. (200 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1164 aa)
	RAP2B	RAP2B, member of RAS oncogene family. (183 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (191 aa)
	DBNL	Drebrin like. (484 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1504 aa)
	RHOH	Ras homolog family member H. (191 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1284 aa)
	EPS8L3	EPS8 like 3. (596 aa)
	rapgef6	Uncharacterized protein. (1660 aa)
	RRAS2	RAS related 2. (203 aa)
	PLEKHG7	Chromosome 12 open reading frame 74. (378 aa)
	CDC42	Uncharacterized protein. (80 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1254 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (340 aa)
	LOC100564830	Uncharacterized protein. (618 aa)
	RALGPS2	Ral GEF with PH domain and SH3 binding motif 2. (584 aa)
	H9GK25_ANOCA	Uncharacterized protein. (118 aa)
	rab4b	Uncharacterized protein. (213 aa)
	LOC100558908	Uncharacterized protein. (326 aa)
	RRAS	RAS related. (203 aa)
	RHOG	Ras homolog family member G. (191 aa)
	RIT2	Ras like without CAAX 2. (218 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (820 aa)
	RASGRP2	RAS guanyl releasing protein 2. (277 aa)
	RAB9B	RAB9B, member RAS oncogene family. (201 aa)
	PPP1R21	Protein phosphatase 1 regulatory subunit 21. (781 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (845 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	LOC100562114	Uncharacterized protein. (191 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (921 aa)
	EPS8L2	EPS8 like 2. (736 aa)
	ADGRG1	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (675 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1152 aa)
	CDC42EP1	CDC42 effector protein 1. (420 aa)
	RASGRP1	RAS guanyl releasing protein 1. (729 aa)
	aif1	EF-hand domain-containing protein. (119 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1604 aa)
	KSR2	Kinase suppressor of ras 2. (900 aa)
	EPS8L1	EPS8 like 1. (715 aa)
	NKIRAS2	NFKB inhibitor interacting Ras like 2. (215 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	RACGAP1	Rac GTPase activating protein 1. (629 aa)
	LOC100559807	Uncharacterized protein. (186 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	CNKSR1	Connector enhancer of kinase suppressor of Ras 1. (712 aa)
	WASF2	WASP family member 2. (495 aa)
	RIT1	Ras like without CAAX 1. (224 aa)
	CTNNAL1	Catenin alpha like 1. (707 aa)
	LOC103282347	Integrin_alpha2 domain-containing protein. (329 aa)
	H9GR05_ANOCA	ADF-H domain-containing protein. (328 aa)
	CDC42EP5	CDC42 effector protein 5. (142 aa)
	RANGRF	RAN guanine nucleotide release factor. (195 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRG1	GNA12	ENSACAP00000015103	ENSACAP00000008423	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family.	G protein subunit alpha 12.	0.745
ADGRG1	GNA13	ENSACAP00000015103	ENSACAP00000001821	Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family.	G protein subunit alpha 13.	0.766
AGTR1	GNA13	ENSACAP00000006796	ENSACAP00000001821	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 13.	0.920
ARHGAP35	ARHGAP5	ENSACAP00000011409	ENSACAP00000002689	Rho GTPase activating protein 35.	Rho GTPase activating protein 5.	0.900
ARHGAP35	CDC42	ENSACAP00000011409	ENSACAP00000012248	Rho GTPase activating protein 35.	Uncharacterized protein.	0.640
ARHGAP35	LOC100562114	ENSACAP00000011409	ENSACAP00000014680	Rho GTPase activating protein 35.	Uncharacterized protein.	0.463
ARHGAP35	RHOG	ENSACAP00000011409	ENSACAP00000013782	Rho GTPase activating protein 35.	Ras homolog family member G.	0.463
ARHGAP35	ROCK1	ENSACAP00000011409	ENSACAP00000008028	Rho GTPase activating protein 35.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.402
ARHGAP5	ARHGAP35	ENSACAP00000002689	ENSACAP00000011409	Rho GTPase activating protein 5.	Rho GTPase activating protein 35.	0.900
ARHGAP5	CDC42	ENSACAP00000002689	ENSACAP00000012248	Rho GTPase activating protein 5.	Uncharacterized protein.	0.585
ARHGAP5	LOC100562114	ENSACAP00000002689	ENSACAP00000014680	Rho GTPase activating protein 5.	Uncharacterized protein.	0.455
ARHGAP5	RHOG	ENSACAP00000002689	ENSACAP00000013782	Rho GTPase activating protein 5.	Ras homolog family member G.	0.455
ARHGAP5	RHOH	ENSACAP00000002689	ENSACAP00000011517	Rho GTPase activating protein 5.	Ras homolog family member H.	0.464
ARHGDIA	CDC42	ENSACAP00000010362	ENSACAP00000012248	Rho GDP dissociation inhibitor alpha.	Uncharacterized protein.	0.874
ARHGDIA	CSDE1	ENSACAP00000010362	ENSACAP00000003175	Rho GDP dissociation inhibitor alpha.	Cold shock domain containing E1.	0.421
ARHGDIA	H9GK25_ANOCA	ENSACAP00000010362	ENSACAP00000013371	Rho GDP dissociation inhibitor alpha.	Uncharacterized protein.	0.660
ARHGDIA	HRAS	ENSACAP00000010362	ENSACAP00000014669	Rho GDP dissociation inhibitor alpha.	HRas proto-oncogene, GTPase.	0.421
ARHGDIA	KRAS	ENSACAP00000010362	ENSACAP00000016685	Rho GDP dissociation inhibitor alpha.	KRAS proto-oncogene, GTPase.	0.421
ARHGDIA	LOC100559807	ENSACAP00000010362	ENSACAP00000017128	Rho GDP dissociation inhibitor alpha.	Uncharacterized protein.	0.421
ARHGDIA	LOC100562114	ENSACAP00000010362	ENSACAP00000014680	Rho GDP dissociation inhibitor alpha.	Uncharacterized protein.	0.712