(26 nodes) Regulation of platelet activation network (Anolis carolinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (598 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
	C1QTNF8	C1q and TNF related 8. (199 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
	Emilin2	Uncharacterized protein. (259 aa)
	blk	Tyrosine-protein kinase. (448 aa)
	MMRN1	Multimerin 1. (1200 aa)
	IL6ST	Interleukin 6 signal transducer. (912 aa)
	LYN	Tyrosine-protein kinase. (514 aa)
	GP9	Glycoprotein IX platelet. (176 aa)
	HRG	Histidine rich glycoprotein. (544 aa)
	LOC103282196	Uncharacterized protein. (232 aa)
	IL6	Interleukin 6. (211 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (247 aa)
	MFSD2B	Major facilitator superfamily domain containing 2B. (525 aa)
	C1QTNF1	C1q and TNF related 1. (272 aa)
	GP1BB	Glycoprotein Ib platelet subunit beta. (185 aa)
	Fundc2	Uncharacterized protein. (74 aa)
	SYK	Tyrosine-protein kinase. (634 aa)
	PLEK	Pleckstrin. (358 aa)
	DMTN	Dematin actin binding protein. (389 aa)
	PLA2G4A	Phospholipase A2. (743 aa)
	CD9	Tetraspanin. (225 aa)
	SH2B3	SH2B adaptor protein 3. (568 aa)
	vps33b	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (504 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (396 aa)

Your Current Organism:

Anolis carolinensis

NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fundc2	LYN	ENSACAP00000000488	ENSACAP00000017713	Uncharacterized protein.	Tyrosine-protein kinase.	0.442
GP1BB	GP9	ENSACAP00000000257	ENSACAP00000018430	Glycoprotein Ib platelet subunit beta.	Glycoprotein IX platelet.	0.969
GP9	GP1BB	ENSACAP00000018430	ENSACAP00000000257	Glycoprotein IX platelet.	Glycoprotein Ib platelet subunit beta.	0.969
IL6	IL6ST	ENSACAP00000023010	ENSACAP00000014650	Interleukin 6.	Interleukin 6 signal transducer.	0.997
IL6ST	IL6	ENSACAP00000014650	ENSACAP00000023010	Interleukin 6 signal transducer.	Interleukin 6.	0.997
LYN	Fundc2	ENSACAP00000017713	ENSACAP00000000488	Tyrosine-protein kinase.	Uncharacterized protein.	0.442
LYN	PRKCD	ENSACAP00000017713	ENSACAP00000008435	Tyrosine-protein kinase.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.417
LYN	SYK	ENSACAP00000017713	ENSACAP00000000778	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.879
LYN	prkcq	ENSACAP00000017713	ENSACAP00000005038	Tyrosine-protein kinase.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.423
PRKCD	LYN	ENSACAP00000008435	ENSACAP00000017713	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Tyrosine-protein kinase.	0.417
SYK	LYN	ENSACAP00000000778	ENSACAP00000017713	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.879
SYK	UBASH3B	ENSACAP00000000778	ENSACAP00000004850	Tyrosine-protein kinase.	Ubiquitin associated and SH3 domain containing B.	0.410
SYK	blk	ENSACAP00000000778	ENSACAP00000011257	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.516
UBASH3B	SYK	ENSACAP00000004850	ENSACAP00000000778	Ubiquitin associated and SH3 domain containing B.	Tyrosine-protein kinase.	0.410
blk	SYK	ENSACAP00000011257	ENSACAP00000000778	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.516
prkcq	LYN	ENSACAP00000005038	ENSACAP00000017713	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Tyrosine-protein kinase.	0.423