STRINGSTRING
DMAP1 DMAP1 SIRT6 SIRT6 CHEK1 CHEK1 HDGFL2 HDGFL2 MMS19 MMS19 ACTR2 ACTR2 SETD2 SETD2 MBTD1 MBTD1 ARID2 ARID2 H9G6N6_ANOCA H9G6N6_ANOCA FBH1 FBH1 H9G769_ANOCA H9G769_ANOCA WRAP53 WRAP53 EPC2 EPC2 HELB HELB YEATS4 YEATS4 LOC103282074 LOC103282074 PARP1 PARP1 BRD8 BRD8 RECQL5 RECQL5 EPC1 EPC1 RUVBL1 RUVBL1 KLHL15 KLHL15 H9GCY1_ANOCA H9GCY1_ANOCA RBBP8 RBBP8 LOC100565669 LOC100565669 smchd1 smchd1 WDR48 WDR48 FANCB FANCB PARPBP PARPBP MRGBP MRGBP RIF1 RIF1 HELQ HELQ PIAS4 PIAS4 LOC103282487 LOC103282487 H9GQD0_ANOCA H9GQD0_ANOCA H9GQ09_ANOCA H9GQ09_ANOCA KDM1A KDM1A TIMELESS TIMELESS TRRAP TRRAP mrnip mrnip rmi2 rmi2 PPP4C PPP4C VPS72 VPS72 POGZ POGZ RAD51 RAD51 RUVBL2 RUVBL2 SPIDR SPIDR ERCC6 ERCC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DMAP1DNA methyltransferase 1 associated protein 1. (465 aa)
SIRT6Sirtuin 6. (176 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
HDGFL2HDGF like 2. (420 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (958 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (414 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2626 aa)
MBTD1Mbt domain containing 1. (622 aa)
ARID2AT-rich interaction domain 2. (1840 aa)
H9G6N6_ANOCAUncharacterized protein. (307 aa)
FBH1F-box DNA helicase 1. (1043 aa)
H9G769_ANOCADUF3715 domain-containing protein. (395 aa)
WRAP53WD repeat containing antisense to TP53. (383 aa)
EPC2Enhancer of polycomb homolog. (806 aa)
HELBDNA helicase B. (1040 aa)
YEATS4YEATS domain containing 4. (227 aa)
LOC10328207453-BP1_Tudor domain-containing protein. (1012 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1006 aa)
BRD8Bromodomain containing 8. (1252 aa)
RECQL5RecQ like helicase 5. (1015 aa)
EPC1Enhancer of polycomb homolog. (742 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
KLHL15Kelch like family member 15. (604 aa)
H9GCY1_ANOCARap1_C domain-containing protein. (116 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
LOC100565669Uncharacterized protein. (1422 aa)
smchd1SMC hinge domain-containing protein. (508 aa)
WDR48WD repeat domain 48. (692 aa)
FANCBFA complementation group B. (836 aa)
PARPBPPARP1 binding protein. (442 aa)
MRGBPMRG domain binding protein. (240 aa)
RIF1Replication timing regulatory factor 1. (2361 aa)
HELQHelicase, POLQ like. (1045 aa)
PIAS4Protein inhibitor of activated STAT 4. (212 aa)
LOC103282487FAM35_C domain-containing protein. (146 aa)
H9GQD0_ANOCAUncharacterized protein. (422 aa)
H9GQ09_ANOCAFAM35_C domain-containing protein. (867 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
TIMELESSTimeless circadian regulator. (1204 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3856 aa)
mrnipUncharacterized protein. (120 aa)
rmi2Uncharacterized protein. (153 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
VPS72Vacuolar protein sorting 72 homolog. (329 aa)
POGZPogo transposable element derived with ZNF domain. (1447 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (462 aa)
SPIDRScaffold protein involved in DNA repair. (990 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1440 aa)
Your Current Organism:
Anolis carolinensis
NCBI taxonomy Id: 28377
Other names: A. carolinensis, Carolina anole, UCMZ 53793, green anole
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